Dissemination with Malignant Changes from a Pineal Tumor through the Corpus callosum after Total Removal

Abstract

Within the germinal neoplasms of the central nervous system, the embryonal carcinoma is a very rare tumor. The authors report such a lesion arising on the corpus callosum in a child 8 months after a differentiated teratoma was totaly removed from the pineal region. The classification of the germ cell tumors of the central nervous system and their relation with similar tumors of the gonads are discussed. The treatment of the pineal tumors is also discussed.

Stroke-Like Onset of Pineal Region Tumors in Two Children

“…It seemed interesting to us to study, via a series of CTs done at signif icant times in the evolution of the clinical manifestations of our young patient which in turn showed a significant malignancy, the rapid local growth and structural modifications, all without further metastasization. In the case reported by Schindler et al [1977], an analogous study with an even more rapid evolution permitted the demonstration of the imposing metastitization (by means of adventitial and liquoral ways) of the tumor notwithstanding the intense radiation treatment and as a matter of fact, the same author does not exclude the possibility of an increase in malignancy of the neoplastic cells induced by radiation given for therapeutic reasons; this hypothesis would invalidate the concept of Carillo et al [1977] who recommended early irradiation of the entire nervous system. The multi plicity oflhe ncuropalhological aspects of tumors of the pineal region and the unpredictability of their biological behavior would definitely explain the variability of the onset and the evolution of the corresponding clinical manifestation which makes therapeutic behavior all the more problematic and noncodifiable.…”

Extremely Late Recurrence 21 Years after Total Removal of Immature Teratoma: A Case Report and Literature Review

“…2,3,26) However, some patients with mature teratoma have developed recurrent GCTs even after gross total resection. 8 –13,22,27–29) Histological diagnoses of the secondary lesion found pathology other than mature teratoma in most cases. One explanation for this finding is that a small component of germinoma or malignant GCT was overlooked at initial treatment as the present case.…”

Germinoma With Syncytiotrophoblastic Giant Cells Arising in the Corpus Callosum -Case Report-

“…Germ cell tumors including germinomas in the corpus callosum are very rare and are usually associated with other intracranial lesions. 1,7,9,11,[16][17][18][19][20] Only one of 153 germ cell tumors was located in the corpus callosum (0.7%). 11) The reason for the low incidence of germ cell tumors arising at the corpus callosum is unclear, but may be related to the pathogenesis of intracranial germ cell tumors.…”

“…Only 11 patients with germ cell tumors in the corpus callosum have been reported, 1,7,9,11,[16][17][18][19][20] all associated other intracranial lesions including disseminated periventricular tumors, adjacent cerebral parenchymal lesions, and so-called favorite site lesions (Table 1). Patients with corpus callosum germ cell tumors tended to be older (mean ± standard deviation [SD] 23.7 ± 10.9 years) than patients with more common intracranial germinomas.…”