Dissipation Kinetics of Cyazofamid in Water

Tandon, Shishir; Singh, N. P.

doi:10.1080/10826076.2014.999868

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Previous studies have already shown that CCIM appears to be more acutely toxic than cyazofamid ( European Food Safety Authority 2016). LC as well as LC–MS have been used to analyse cyazofamid and CCIM. Dissipation of cyazofamid has been determined in tobacco and tomato .…”

Section: Introductionmentioning

confidence: 99%

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Pang

Dou

2019

J Sci Food Agric

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BACKGROUND Grape is an important fruit consumed either fresh or processed, therefore, fungicide misuse of grape has become an issue of global food safety and human health. Pyraclostrobin, and cyazofamid have been applied to grape frequently. RESULTS Here a simple QuEChERS (quick, easy, cheap, effective, rugged, and safe) liquid chromatography mass spectrometry technique has been developed and validated for the determination of pyraclostrobin, cyazofamid and its metabolite CCIM in open field grape samples. The recoveries of these three in the range of 0.01 to 5 mg kg−1 (n = 5) ranged from 73.1% to 97.9%. The relative standard deviations (RSDs) were below 12% for all cases. The limits of quantitation of each analyte was 0.005 mg kg−1, which was lower than maximum residue limits of not only pyraclostrobin but also cyazofamid. Not only dissipation kinetics but also residue determination was obtained in grape for those three pesticides. Furthermore, their half‐lives in grapes were 10.7–30.1 days, recommending the pre‐harvest intervals for these three of 14 days. The calculated hazard quotient and acute hazard index lower than 100% illustrated the safety of intake of grape for the Chinese population for not only long‐term but also short‐term dietary risk assessment. CONSLUSIONS The less than 30 day half‐life illustrated that pyraclostrobin and cyazofamid could degrade relatively easily in the environment. The long‐term and short‐term dietary risk assessment also illustrated the intake safety of these three. Thus, a 14 day pre‐harvest interval was safe and recommended. The results of this study contributed to environmental protection, food safety and human health. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Pang

Dou

2019

J Sci Food Agric

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“…Many studies have investigated residues of metalaxyl or cyazofamid in crops using high‐performance liquid chromatography (HPLC) (Lee et al, ; Malhat, ; Singh & Tandon, ; Tandon & Singh, ; Zheng, Feng, Ge, Lv, & Xie, ), ultra‐performance liquid chromatography (Liu et al, ), gas chromatography (GC) (Rani, V. K. Sharma, Rattan, Singh, & Sharma, ; Rattan & Sharma, ) and liquid chromatography with tandem mass spectrometry (LC‐MS/MS) (Lee et al, ; Li et al, ; Ramezani & Shahriari, ; Zhu et al, ). For example, Zheng et al () used a QuEChERS (quick, easy, cheap, effective, rugged and safe) HPLC method to detect trace amounts of metalaxy in watermelon, and the average recovery rates were between 92.20 and 98.90%.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of residues of metalaxyl, cyazofamid and a cyazofamid metabolite in tobacco leaves and soil by liquid chromatography with tandem mass spectrometry

Sun

et al. 2018

Biomedical Chromatography

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A simple method was developed and validated for the simultaneous determination of metalaxyl, cyazofamid and the cyazofamid metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM) by liquid chromatography with tandem mass spectrometry. The three target compounds were extracted from tobacco and soil with acetonitrile containing 0.1% acetic acid, and the extracts were purified using octadecylsilane. The proposed method showed satisfactory linearity (R ≥ 0.9985) for the target compounds. The limits of detection for metalaxyl, cyazofamid and CCIM were 0.006, 0.06 and 0.06 mg/kg in soil and green tobacco leaves and 0.03, 0.3 and 0.3 mg/kg in cured tobacco leaves, respectively. The limits of quantification for metalaxyl, cyazofamid and CCIM were 0.02, 0.2 and 0.2 mg/kg in soil and green tobacco leaves and 0.1, 1 and 1 mg/kg in cured tobacco leaves, respectively. The average recoveries from soil and tobacco were 72.91-98.40% for metalaxyl, 76.73-105.80% for cyazofamid and 74.48-106.45% for CCIM. The relative standard deviation range was 1.23-6.99%. The developed method was successfully applied to analysis of residues of metalaxyl, cyazofamid and CCIM in real soil and tobacco samples. The results indicated that the established method could meet the requirement for the analysis of trace amounts of all three analytes in soil and tobacco.

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Identification and formation pattern of metabolites of cyazofamid by soil fungus Cunninghamella elegans

et al. 2015

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Dissipation Kinetics of Cyazofamid in Water

Cited by 7 publications

References 13 publications

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Simultaneous determination of residues of metalaxyl, cyazofamid and a cyazofamid metabolite in tobacco leaves and soil by liquid chromatography with tandem mass spectrometry

Identification and formation pattern of metabolites of cyazofamid by soil fungus Cunninghamella elegans

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