Dissociable contributions of the prefrontal and neocerebellar cortex to time perception

Mangels, Jennifer A.; Ivry, Richard B.; Shimizu, Naomi

doi:10.1016/s0926-6410(98)00005-6

Cited by 283 publications

(255 citation statements)

References 94 publications

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“…Compatible with these results, we provided evidence for the functional dissociation of temporal duration and spatial location working memory in intact young adults using a selective interference paradigm (H€ a albig, Mecklinger, Schriefers, & Friederici, 1998). Lesion studies support the notion that the frontal cortex is involved in duration processing (Casini & Ivry, 1999;Mangels et al, 1998;Nichelli et al, 1995). Using a bisection procedure, Nichelli et al (1995) found impaired accuracy on duration discrimination in the millisecond range (100-900 ms) and for longer intervals (8-32 s), but normal performance on a line-length discrimination task.…”

Section: Introductionmentioning

confidence: 63%

“…The precise functional role of the frontal cortex in particular is a subject of considerable controversy (Gibbon et al, 1997). Frontal lobe function has been brought in touch in different theories with clock or counter mechanisms (Grafman, 1989;Miall, 1996;Niki & Watanabe, 1979) as well as with the memory stage (Mangels, Ivry, & Shimizu, 1998;Nichelli et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Studies with brain damaged patients provided evidence for prefrontal cortical involvement in the processing of temporal information in memory (Kesner, Hopkins, & Fineman, 1994;Mangels, 1997;Mangels et al, 1998;McAndrews & Milner, 1991;Milner, Corsi, & Leonard, 1991;Nichelli et al, 1995;Shimamura, Janowsky, & Squire, 1990). Regarding temporal order, several studies indicated a dissociation of temporal order and item memory (Cabeza et al, 1997;Kesner et al, 1994;McAndrews & Milner, 1991;Milner et al, 1991;Shimamura et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Concerning the processing of duration information, recent electrophysiological (Casini & Macar, 1996;Elbert, Ulrich, Rockstroh, & Lutzenberger, 1991;Schubotz & Friederici, 1997) and lesions studies (Casini & Ivry, 1999;Mangels et al, 1998;Nichelli et al, 1995) have also emphasized the involvement of frontal brain structures. For example, in a study using event-related brain potentials (ERP), differently distributed ERPs were reported for temporal duration and spatial location working memory tasks with stimulus durations in the millisecond range (275, 300, 570, 650 ms).…”

Section: Introductionmentioning

confidence: 99%

“…Considering duration as a stimulus dimension (equivalent to shape and location), one could be tempted to suppose domain-specific neural assemblies contributing to duration processing. However, even if there is considerable evidence that memory for temporal duration depends on the integrity of the frontal lobes (Casini & Ivry, 1999;Casini & Macar, 1996;Elbert et al, 1991;Mangels et al, 1998;Nichelli et al, 1995;Schubotz & Friederici, 1997), variability of lesion size and location in the cited neuropsychological studies do not allow to identify any specific area within the frontal cortex that is involved necessarily in the processing of temporal duration information.…”

Section: Introductionmentioning

confidence: 99%

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Processing of temporal duration information in working memory after frontodorsal tumour excisions

Hälbig

Cramon

Schmid

et al. 2002

Brain and Cognition

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This study aimed to test the hypothesis that impairments of temporal duration processing after frontal lobe lesions reflect deficits in executive monitoring functions rather than a domain-specific deficit in the maintenance of duration information in working memory. Patients with frontodorsal lesions, clinical controls with post-central lesions, and healthy controls performed recognition and classification tasks, which should allow for testing maintenance and monitoring functions, respectively. Results showed mild non-selective impairments of the frontal patients on both temporal and spatial recognition tasks, but a marked selective degradation on temporal classification while performance on spatial classification was unimpaired. This suggests that maintenance of duration information in working memory after frontal lesions is basically preserved but that, depending on executive task characteristics, there is a specific deficit in the strategic organization of this type of information.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Hälbig

Cramon

Schmid

et al. 2002

Brain and Cognition

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A new account of the neurocognitive foundations of impairments in space, time, and number processing in children with chromosome 22q11.2 deletion syndrome

Simon

2008

Dev Disabil Res Revs

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In this paper I present an updated account that attempts to explain, in cognitive processing and neural terms, the nonverbal intellectual impairments experienced by most children with deletions of chromosome 22q11.2. Specifically, I propose that this genetic syndrome leads to early developmental changes in the structure and function of clearly delineated neural circuits for basic spatiotemporal cognition. This dysfunction then cascades into impairments in basic magnitude and then numerical processes, because of the central role that representations of space and time play in their construction. I propose that this takes the form of "spatiotemporal hypergranularity"; the increase in grain size and thus reduced resolution of mental representations of spatial and temporal information. The result is that spatiotemporal processes develop atypically and thereby produce the characteristic impairments in nonverbal cognitive domains that are a hallmark feature of chromosome 22q11.2 deletion syndrome. If this hypothesis driven account is supported by future research, the results will create a neurocognitive explanation of spatiotemporal and numerical impairments in the syndrome that is specific enough to be directly translated into the development of targeted therapeutic interventions.

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Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Petacchi

Laird

Fox³

et al. 2005

Human Brain Mapping

208

174

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Abstract:Over the past two decades neuroimaging data have accumulated showing that the cerebellum, traditionally viewed only as a motor structure, is also active in a wide variety of sensory and cognitive tasks. We have proposed that instead of explicit involvement in any particular motor, sensory, or cognitive task, the cerebellum performs a much more fundamental computation involving the active acquisition of sensory data. We carried out an activation likelihood estimate (ALE) meta-analysis to determine whether neuroimaging results obtained during a wide range of auditory tasks support this proposal. Specifically, we analyzed the coordinates of 231 activation foci obtained in 15 different auditory studies selected through an extensive search of the positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) literature. The studies selected represent a wide variety of purely auditory tasks using highly controlled synthesized acoustic stimuli. The results clearly revealed that in addition to temporal auditory areas of cerebral cortex, specific regions in the cerebellum are activated consistently across studies regardless of the particular auditory task involved. In particular, one area in left lateral crus I area showed the greatest volume and ALE peak value among the extratemporal regions. A subanalysis was carried out that ruled out the specific association of this cerebellar cluster with attentional demand. The results are consistent with the hypothesis that the cerebellum may play a role in purely sensory auditory processing, and are discussed in light of the broader idea of the cerebellum subserving a fundamental sensory function. Hum Brain Mapp 25:118 -128, 2005.

show abstract

Dissociable contributions of the prefrontal and neocerebellar cortex to time perception

Cited by 283 publications

References 94 publications

Processing of temporal duration information in working memory after frontodorsal tumour excisions

Processing of temporal duration information in working memory after frontodorsal tumour excisions

A new account of the neurocognitive foundations of impairments in space, time, and number processing in children with chromosome 22q11.2 deletion syndrome

Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

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