Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study

Dolcos, Florin; LaBar, Kevin S.; Cabeza, Roberto

doi:10.1016/j.neuroimage.2004.05.015

Cited by 377 publications

(336 citation statements)

References 83 publications

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“…These findings are consistent with previous studies that investigated the influence of emotion on the recall or recognition of pictures similar to those used in the present study (e.g., Bradley, Greenwald, Petry, & Lang, 1992;Comblain et al, 2004;Dolcos, LaBar, & Cabeza, 2004;Hamann, Ely, Grafton, & Kilts, 1999;Ochsner, 2000). This difference in item memory between emotional and neutral pictures may involve mechanisms such as enhanced attention to, and hence encoding of, emotional items as well as enhanced consolidation or storage of emotional items, mechanisms that are thought to be underlain by a specific neuro-hormonal system (McGaugh & Cahill, 2003;Phelps, 2004).…”

Section: Discussionsupporting

confidence: 94%

Influence of Emotion on Memory for Temporal Information.

D’Argembeau

Linden

2005

Emotion

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Contextual information, such as color and spatial location, has been found to be better remembered for emotional than for neutral items. The current study examined whether the influence of emotion extends to memory for another fundamental feature of episodic memory: temporal information. Results from a list-discrimination paradigm showed that (a) item memory was enhanced for both negative and positive pictures compared with neutral ones and was better for negative than for positive pictures and (b) temporal information was better remembered for negative than for positive and neutral pictures, whereas positive and neutral pictures did not differ from each other. These findings are discussed in relation to the processes involved in memory for temporal information.

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Section: Discussionsupporting

confidence: 94%

Influence of Emotion on Memory for Temporal Information.

D’Argembeau

Linden

2005

Emotion

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“…Animal studies have demonstrated that amygdala stimulation facilitates hippocampal-dependent learning (Ikegaya et al 1996;Packard et al 1994). The enhancing effect of amygdala activity on emotional memory consolidation is a wellestablished finding in the imaging literature relating activity in the amygdala to later retrieval success (Cahill et al 1996;Canli et al 2000;Dolcos et al 2004Dolcos et al , 2005Hamann et al 1999;rev: LaBar and Cabeza 2006). In addition, negative memory biases are often found in stressrelated disorders (e.g., Bradley et al 1996;Ridout et al 2009;Watkins et al 1992).…”

Section: Discussionmentioning

confidence: 97%

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

et al. 2014

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Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stress-sensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxel-based morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective selfreport (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-environment interaction on right amygdala activity with respect to retrospective assessment of childhood adversity, but clarify that this does not generalize to the prospective assessment. These findings indicated that activity in T homozygotes increased with the level of adversity, whereas the opposite pattern emerged in C homozygotes, with CT individuals being intermediate. Abstract Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stresssensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxelbased morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective selfreport (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-env...

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“…Consistent with the present findings, many studies now suggest that amygdala activation near the inception of memory consolidation is correlated with enhanced long term memory. Activation in the amygdala during viewing of emotionally arousing events predicts later memory (22,24,49,51,58), with amygdala activation and degree of arousal conjointly predicting memory on an event-by-event basis. However, the amygdala has also been shown in both human and nonhuman animals to play an important role in the allocation of attention to emotionally significant events (9,(59)(60)(61).…”

Section: Discussionmentioning

confidence: 99%

Emotion enhances remembrance of neutral events past

Anderson

Wais

Gabrieli

2006

Proc. Natl. Acad. Sci. U.S.A.

221

218

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Emotional events are bestowed with special prominence in memory. This may reflect greater attention oriented to these events during encoding, and͞or enhancement of memory consolidation after emotional events have passed. Here we show invoked emotional arousal results in a retrograde enhancement of long-term memory, determining what will later be remembered or forgotten. Subjects saw pictures of neutral faces and houses followed by emotionally arousing scenes at varying intervals. Self-reported emotional arousal responses predicted a retrograde enhancement of memory for preceding neutral events in a 1-week delayed recognition memory test. At longer picture-scene intervals, no enhancement was found, implicating a critical window in which emotional arousal must occur for retrograde memory enhancement. Postencoding manipulation of emotional arousal specifically enhanced conscious recollection rather than familiarity-based discrimination. An additional study revealed no retrograde enhancement for pictures preceding highly memorable, but nonarousing, distinctive scenes. These findings indicate an important role for emotional arousal in the postencoding enhancement of episodic memory consolidation.amygdala ͉ consolidation ͉ hippocampus ͉ memory ͉ arousal

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Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study

Cited by 377 publications

References 83 publications

Influence of Emotion on Memory for Temporal Information.

Influence of Emotion on Memory for Temporal Information.

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

Emotion enhances remembrance of neutral events past

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