Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain

Tanaka, Masaki; Osada, Takahiro; Ogawa, Akitoshi; Kamagata, Koji; Aoki, Shigeki; Konishi, Seiki

doi:10.3389/fnhum.2020.00228

Cited by 9 publications

(4 citation statements)

References 63 publications

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“…Therefore, our findings provide a plausible link between a genetic predisposition by variation in ST8SIA2 and neurodevelopmental psychiatric disorders. Future studies should address this possibility, e.g., by advanced brain imaging methods [ 60 , 61 ] or postmortem analyses of patients with neurodevelopmental psychiatric disorders that have been associated with genetic variation in ST8SIA2 .…”

Section: Discussionmentioning

confidence: 99%

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2

et al. 2022

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Altered long-range connectivity is a common finding across neurodevelopmental psychiatric disorders, but causes and consequences are not well understood. Genetic variation in ST8SIA2 has been associated with schizophrenia, autism, and bipolar disorder, and St8sia2−/− mice show a number of related neurodevelopmental and behavioral phenotypes. In the present study, we use conditional knockout (cKO) to dissect neurodevelopmental defects and behavioral consequences of St8sia2 deficiency in cortical interneurons, their cortical environment, or in the di- and mesencephalon. Neither separate nor combined cortical and diencephalic ablation of St8sia2 caused the disturbed thalamus-cortex connectivity observed in St8sia2−/− mice. However, cortical ablation reproduced hypoplasia of corpus callosum and fornix and mice with di- and mesencephalic ablation displayed smaller mammillary bodies with a prominent loss of parvalbumin-positive projection neurons and size reductions of the mammillothalamic tract. In addition, the mammillotegmental tract and the mammillary peduncle, forming the reciprocal connections between mammillary bodies and Gudden’s tegmental nuclei, as well as the size of Gudden’s ventral tegmental nucleus were affected. Only mice with these mammillary deficits displayed enhanced MK-801-induced locomotor activity, exacerbated impairment of prepulse inhibition in response to apomorphine, and hypoanxiety in the elevated plus maze. We therefore propose that compromised mammillary body connectivity, independent from hippocampal input, leads to these psychotic-like responses of St8sia2-deficient mice.

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Section: Discussionmentioning

confidence: 99%

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2

et al. 2022

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“…Functional images were then obtained using multi-band gradient-echo echo-planar sequences (TR = 1.0 s, TE = 30 msec, flip angle = 62 deg, FOV = 192 3 192 mm 2 , matrix size = 96 3 96, 78 contiguous slices, voxel size = 2.0 3 2.0 3 2.0 mm 3 , multi-band factor = 6, phase-encoding direction = posterior to anterior). In the resting-state scan, subjects were asked to fixate on a cross displayed on a screen (Osada et al, 2017(Osada et al, , 2019Tanaka et al, 2020). One run consisted of 360 volumes, and 10 runs were administered.…”

Section: Mri Proceduresmentioning

confidence: 99%

Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response inhibition

et al. 2021

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“…2019 ; Fujimoto et al. 2020 ; Tanaka et al. 2020 ), subjects were asked to fixate on a cross displayed on a screen.…”

Section: Methodsmentioning

confidence: 99%

Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains

et al. 2020

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The right inferior frontal cortex (IFC) is critical to response inhibition. The right IFC referred in the human studies of response inhibition is located in the posterior part of the inferior frontal gyrus and the surrounding regions and consists of multiple areas that implement distinct functions. Recent studies using resting-state functional connectivity have parcellated the cerebral cortex and revealed across-subject variability of parcel-based cerebrocortical networks. However, how the right IFC of individual brains is functionally organized and what functional properties the IFC parcels possess regarding response inhibition remain elusive. In the present functional magnetic resonance imaging study, precision functional mapping of individual human brains was adopted to the parcels in the right IFC to evaluate their functional properties related to response inhibition. The right IFC consisted of six modules or subsets of subregions, and the spatial organization of the modules varied considerably across subjects. Each module revealed unique characteristics of brain activity and its correlation to behavior related to response inhibition. These results provide updated functional features of the IFC and demonstrate the importance of individual-focused approaches in studying response inhibition in the right IFC.

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Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain

Cited by 9 publications

References 63 publications

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2

Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response inhibition

Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains

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