Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains

Abstract

The right inferior frontal cortex (IFC) is critical to response inhibition. The right IFC referred in the human studies of response inhibition is located in the posterior part of the inferior frontal gyrus and the surrounding regions and consists of multiple areas that implement distinct functions. Recent studies using resting-state functional connectivity have parcellated the cerebral cortex and revealed across-subject variability of parcel-based cerebrocortical networks. However, how the right IFC of individual brains is functionally organized and what functional properties the IFC parcels possess regarding response inhibition remain elusive. In the present functional magnetic resonance imaging study, precision functional mapping of individual human brains was adopted to the parcels in the right IFC to evaluate their functional properties related to response inhibition. The right IFC consisted of six modules or subsets of subregions, and the spatial organization of the modules varied considerably across subjects. Each module revealed unique characteristics of brain activity and its correlation to behavior related to response inhibition. These results provide updated functional features of the IFC and demonstrate the importance of individual-focused approaches in studying response inhibition in the right IFC.

Light through the fog: using precision fMRI data to disentangle the neural substrates of cognitive control

“…The benefits of individualized brain maps are not restricted to the study of distributed cortical territories, but can also help illuminate the function of specific sub-regions in cognitive control. For example, Suda and colleagues individually defined six sub-regions within the right inferior frontal cortex (rIFC) and demonstrated that these sub-regions differ in their involvement in response inhibition [43]. As with the previously described sensory and motor functional sub-divisions, the relationships between the six rIFC sub-regions and cognitive inhibition were generally stronger for individual vs. group-level parcels.…”

Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response inhibition

“…The IFC consists of several cortical areas with different functional characteristics (Suda et al, 2020). In particular, a functional dissociation related to response inhibition inside the IFC has been reported between the vpIFC and dpIFC (Fujimoto et al, 2020).…”

“…Five areas of interest in the right cerebral cortical parcels were selected based on their known association with response inhibition: two dissociable areas in the posterior inferior frontal cortex (IFC) (Fujimoto et al, 2020;Suda et al, 2020), namely the ventral posterior IFC (vpIFC) and dorsal posterior IFC (dpIFC); the inferior frontal junction (IFJ) (Verbruggen et al, 2010); the presupplementary motor area (preSMA) (Floden and Stuss, 2006;Nachev et al, 2007;Watanabe et al, 2015), and the intraparietal sulcus (IPS) (Osada et al, 2019). The MNI coordinates of the centroids of the five areas were: (52, 14, 8) for the vpIFC, (44,8,20) for the dpIFC, (34, 10, 30) for the IFJ, (10, 0, 70) for the preSMA, and (42, À46, 44) for the IPS.…”

Time‐varying measures of cerebral network centrality correlate with visual saliency during movie watching

“…This study adopted a parcel‐based technique to analyze the network centrality during movie‐watching. Parcel‐based analysis is becoming popular, not only for the resting state but for task‐induced activation (Allan et al., 2019 ; Osada et al., 2019 ; Fujimoto et al., 2020 ; Suda et al., 2020 ). The main benefit of the parcel‐based analysis, over voxel‐wise or vertex‐wise analysis of the whole brain, is lower computational load in both time and memory.…”