Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice

Yan, Yijin; Nitta, Atsumi; Koseki, Takenao; Yamada, Kiyofumi; Nabeshima, Toshitaka

doi:10.1007/s00213-011-2589-5

Cited by 14 publications

(14 citation statements)

References 37 publications

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“…It was reported that the levels of circulating TNF-α have been altered in alcoholics, cocaine abusers and opiate addicts. In addition, it has been suggested that TNF-α can be a potential diagnostic biomarker for drugs of abuse [ 60 , 61 , 62 , 63 , 64 , 65 ]. In an animal model, TNF-α has been investigated as a potential therapeutic target to prevent drug abuse and to increase the chance of cessation.…”

Section: Discussionmentioning

confidence: 99%

“…In an animal model, TNF-α has been investigated as a potential therapeutic target to prevent drug abuse and to increase the chance of cessation. [ 61 ]. The current findings of the association of low TNF-α with food addiction is very interesting and unique.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the YFAS and Willett Food Frequency Questionnaire (FFQ) were used as tools for the diagnosis of food addiction and measuring nutrient intake over the past 12 months. These sets of measures and the criteria on which they are based have been validated in different populations [ 7 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. The YFAS is the only tool available for the diagnosis of food addiction.…”

Section: Discussionmentioning

confidence: 99%

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Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction

Pedram

Sun

2014

Nutrients

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The concept of food addiction (FA) is a potentially important contributing factor to the development of obesity in the general population; however, little is known about the hormonal and dietary differences between obesity with and without FA. Therefore, the aim of our study was to explore potential biomarkers, including various hormones and neuropeptides, which regulate appetite and metabolism, and dietary components that could potentially differentiate obesity with and without FA. Of the 737 adults recruited from the general Newfoundland population, 58 food-addicted and non-food-addicted overweight/obese individuals (FAO, NFO) matched for age, sex, BMI and physical activity were selected. A total of 34 neuropeptides, gut hormones, pituitary polypeptide hormones and adipokines were measured in fasting serum. We found that the FAO group had lower levels of TSH, TNF-α and amylin, but higher levels of prolactin, as compared to NFO group. The total calorie intake (per kg body weight), the dietary intake of fat (per g/kg body weight, per BMI and per percentage of trunk fat) and the percent calorie intake from fat and carbohydrates (g/kg) was higher in the FAO group compared to the NFO group. The FAO subjects consumed more sugar, minerals (including sodium, potassium, calcium and selenium), fat and its components (such as saturated, monounsaturated and trans fat), omega 3 and 6, vitamin D and gamma-tocopherol compared to the NFO group. To our knowledge, this is the first study indicating possible differences in hormonal levels and micro-nutrient intakes between obese individuals classified with and without food addiction. The findings provide insights into the mechanisms by which FA could contribute to obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction

Pedram

Sun

2014

Nutrients

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“…Consistent with these findings, mice treated with methamphetamine show brain region-specific increases in the expression of proinflammatory cytokines (e.g., IL-1β) up to 3 weeks after methamphetamine exposure (Loftis et al, 2011). In a rigorous study designed to evaluate whether or not deletion of the TNF-α gene in mice affects addictive-like behavior, including methamphetamine self-administration, motivation to self-administer methamphetamine, and cue-induced reinstatement of methamphetamine-seeking behavior, Yan, Nitta, Koseki, Yamada, and Nabeshima (2012) measured methamphetamine self-administration and reinstatement of drug-seeking behavior in TNF-α knock-out and wild-type mice. The authors observed an upward shift of dose responses to methamphetamine self-administration under a fixed ratio schedule of reinforcement in the TNF-α knockout as compared with wild-type mice, indicating that mice lacking TNF-α administered more methamphetamine than controls.…”

Section: Partmentioning

confidence: 99%

“…Taken together, these findings demonstrate that TNF-α signaling affects methamphetamine self-administration and motivation to obtain the drug. However, TNF-α did not appear to contribute to methamphetamine-associated cue-induced relapsing behavior (Yan et al, 2012). …”

Section: Partmentioning

confidence: 99%

Neuroimmune Basis of Methamphetamine Toxicity

Loftis

Janowsky

2014

International Review of Neurobiology

105

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Although it is not known which antigen-specific immune responses (or if antigen-specific immune responses) are relevant or required for methamphetamine's neurotoxic effects, it is apparent that methamphetamine exposure is associated with significant effects on adaptive and innate immunity. Alterations in lymphocyte activity and number, changes in cytokine signaling, impairments in phagocytic functions, and glial activation and gliosis have all been reported. These drug-induced changes in immune response, particularly within the CNS, are now thought to play a critical role in the addiction process for methamphetamine dependence as well as for other substance use disorders. In Section 2, methamphetamine's effects on glial cell (e.g., microglia and astrocytes) activity and inflammatory signaling cascades are summarized, including how alterations in immune cell function can induce the neurotoxic and addictive effects of methamphetamine. Section 2 also describes neurotransmitter involvement in the modulation of methamphetamine's inflammatory effects. Section 3 discusses the very recent use of pharmacological and genetic animal models which have helped elucidate the behavioral effects of methamphetamine's neurotoxic effects and the role of the immune system. Section 4 is focused on the effects of methamphetamine on blood–brain barrier integrity and associated immune consequences. Clinical considerations such as the combined effects of methamphetamine and HIV and/or HCV on brain structure and function are included in Section 4. Finally, in Section 5, immune-based treatment strategies are reviewed, with a focus on vaccine development, neuroimmune therapies, and other anti-inflammatory approaches.

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Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study

Sandau

Duggan

Shi

et al. 2020

J of Extracellular Vesicle

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Methamphetamine (MA) is the largest drug threat across the globe, with health effects including neurotoxicity and cardiovascular disease. Recent studies have begun to link microRNAs (miRNAs) to the processes related to MA use and addiction. Our studies are the first to analyse plasma EVs and their miRNA cargo in humans actively using MA (MA‐ACT) and control participants (CTL). In this cohort we also assessed the effects of tobacco use on plasma EVs. We used vesicle flow cytometry to show that the MA‐ACT group had an increased abundance of EV tetraspanin markers (CD9, CD63, CD81), but not pro‐coagulant, platelet‐, and red blood cell‐derived EVs. We also found that of the 169 plasma EV miRNAs, eight were of interest in MA‐ACT based on multiple statistical criteria. In smokers, we identified 15 miRNAs of interest, two that overlapped with the eight MA‐ACT miRNAs. Three of the MA‐ACT miRNAs significantly correlated with clinical features of MA use and target prediction with these miRNAs identified pathways implicated in MA use, including cardiovascular disease and neuroinflammation. Together our findings indicate that MA use regulates EVs and their miRNA cargo, and support that further studies are warranted to investigate their mechanistic role in addiction, recovery, and recidivism.

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Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice

Cited by 14 publications

References 37 publications

Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction

Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction

Neuroimmune Basis of Methamphetamine Toxicity

Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study

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