2011
DOI: 10.1210/en.2010-0940
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Dissociation of Epidermal Growth Factor Receptor and ErbB2 Heterodimers in the Presence of Somatostatin Receptor 5 Modulate Signaling Pathways

Abstract: Epidermal growth factor through the stimulation of epidermal growth factor receptor (EGFR) plays a critical role in the activation of MAPKs and phosphatidylinositol-3-protein kinase/AKT cell survival pathways attributed in many pathological conditions. At the cellular level, such functions involve EGFR overactivation and phosphorylation. In the present study, we describe that human embryonic kidney-293 cells transfected with somatostatin (SST) receptor 5 (SSTR5) exhibit inhibition of EGFR phosphorylation and m… Show more

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Cited by 17 publications
(40 citation statements)
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“…SSTR subtypes not only heterodimerize within the family but does so with other members of GPCR family like dopamine, opioid, adrenergic, and growth factor receptors [28,30,31,[34][35][36][37][38][39][40][41][42][43]. In addition to displaying receptorspecific dimerization, SSTR subtypes have shown great diversity upon heterodimerization as well.…”
Section: Heterodimerization Of Sst Receptorsmentioning
confidence: 99%
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“…SSTR subtypes not only heterodimerize within the family but does so with other members of GPCR family like dopamine, opioid, adrenergic, and growth factor receptors [28,30,31,[34][35][36][37][38][39][40][41][42][43]. In addition to displaying receptorspecific dimerization, SSTR subtypes have shown great diversity upon heterodimerization as well.…”
Section: Heterodimerization Of Sst Receptorsmentioning
confidence: 99%
“…With respect to the formation of SSTR2 and D2R heterodimers, dopamine affinity was increased and SSTR2 functions remained unchanged [35]. Furthermore, recent studies have also described that SSTR1 and SSTR5 functionally interact with adrenergic and growth factor receptors with significant changes in receptor coupling to adenylyl cyclase and signaling in receptor specific manner [39][40][41][42][43]. Whether, the activation of two receptors in the presence of receptor-specific agonist also elicit similar effects in cells expressing these receptor endogenously is largely elusive.…”
Section: Heterodimerization Of Sst Receptorsmentioning
confidence: 99%
“…These expansions of protein-protein interaction have been possible only by improved methodological approaches. Interestingly, recent studies suggest that GPCR can also form heterodimers with ligand gated channels such as N-methyl-D-aspartate receptors (NMDARs) and GABA-A receptors as well as receptor tyrosine kinase family [52][53][54][55][56].…”
Section: Exploration Of Receptor Dimerizationmentioning
confidence: 99%
“…Although, studies have described the pharmacological and physiological significance of SSTRs, however the role of SSTR subtypes in pathological conditions still remains elusive. SSTR subtypes not only interact as heterodimers with other closely related receptors including DR, AR and OR subtypes but also constitute functionally active complex with distantly related receptor protein such as NMDA receptors of ionotropic and epidermal growth factor receptors (EGFRs) of receptor tyrosine kinase (RTKs) families and govern many clinical implications [54,55,63,[124][125][126]. If not all, most of the GPCR functions as homo-or heterodimers and the process of heterodimerization may enhance the existing functions of the native receptor.…”
Section: Physiological Significance and Clinical Implication Of Somatmentioning
confidence: 99%
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