Dissolution enhancement of the poorly soluble drug nifedipine by co-spray drying with microporous zeolite beta

Curcumin-loaded zeolite as anticancer drug carrier: effect of curcumin adsorption on zeolite structure

“…In drug delivery, the zeolitic structures loaded with drugs could be administrated to a patient for health treatments, such as cancer therapy, without loss of the individual pharmacological effect of the products. In addition, zeolites can bind and encapsulate drugs with low aqueous solubility, thus increasing significantly their bioavailability in the physiological environment [16]. Regarding potential toxicity, it has been demonstrated that zeolite toxicity strongly depends on the size, shape and composition of the particles.…”

In vitro and ex vivo assessment of microporous Faujasite zeolite (NaX-FAU) as a carrier for the oral delivery of danazol

“…payload (was 33.3 % w/w). The TGA curves of the NaX-FAU zeolite and danazol are represented by a one stage weight loss (Figure 1A) attributed to the desorption of physically adsorbed water and the thermal decomposition of the drug, respectively [24]. The TGA curve of the drug-loaded formulation was characterized by a threestage weight loss.…”

“…Several inorganic materials have being explored as drug carriers opening new possibilities for biomedical applications [7]. Zeolites are among those materials that have enticed considerable attention in drug delivery, due to their innate unique properties [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Furthermore, it is possible that zeolites provide protection for drugs that are easily decomposed due to humidity, such as degradation [26].…”

Ruthenium tris(2,2′-bipyridyl) complex encapsulated in nanosized faujasite zeolite as intracellular localization tracer

“…Recently, more attention was given to the use of zeolites in biomedical applications 2 as antimicrobial agents, 3,4 anti-cancer drugs carriers, 5 and in the storage and controlled delivery of drugs and gases. [6][7][8] More specifically, they were considered as carriers for the delivery of anti-neoplastic compounds, [9][10][11] nucleic acids, 12,13 both hydrophilic 14,15 and lipophilic drugs, 9,16 anti-inflammatory drugs, 17 and also for the delivery of gases that could be of interest in the biomedical field. 7,18 Faujasite nanozeolite is a potential candidate for biomedical applications due to its large surface area, high micropore volume, and the presence of supercage (1.2 nm) that can host different drugs 19,20 or gases.…”