Dissolution kinetics of zinc oxide and its relationship with physicochemical characteristics

Cardoso, Denise; Narcy, Agnès; Durosoy, S.; Bordes, Claire; Chevalier, Yves

doi:10.1016/j.powtec.2020.10.049

Cited by 32 publications

(21 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The physicochemical properties of powders were shown to influence their in vitro dissolution kinetics, which could explain their different in vivo bioavailability. The previous article (Cardoso et al, 2020) related three main criteria according to the physicochemical of ZnO sources: (1) Small aggregates and agglomerates particles (SAAP), showing a fast dissolution kinetics, related to the small particle size of the powders. ( 2) Large dense particles (LDP), characterized by ZnO sources with low specific area and large size, resulting in a slow dissolution kinetics and (3) Small aggregate particles (SAP), a ZnO source with large agglomerates and large specific surface area that results in an intermediate dissolution kinetics, in which the mechanism is explain in two steps: the fast dissolution in the surface of the powders, followed by the slow diffusion of the ion from the quiescent to the solution media.…”

Section: Discussionmentioning

confidence: 99%

“…The manufacturing process of ZnO yields powder with different physicochemical properties (Moezzi et al, 2012), which lead to variable speed of dissolution in vitro. We showed that these different characteristics could explain the variability observed on Zn bioavailability values (Cardoso et al, 2020). The physicochemical characteristics and the dissolution behaviour allowed classifying the various ZnO grade in three classes as 'Large dense particles' (LDP), 'Small aggregated and agglomerated particles' (SAAP), and 'Small aggregated particles' (SAP).…”

Section: Introductionmentioning

confidence: 93%

“…* Characterization not applicable for ZnSO4 1. Properties are described byCardoso et al (2020).2 The speed of dissolution described in vitro as: (1) +++: fast dissolution, (2) ++ intermediate dissolution and (3) +: slow dissolution rate.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers

Cardoso

Romeo²,

Durosoy³

et al. 2021

British Poultry Science

View full text Add to dashboard Cite

The bioavailability of a trace mineral source is related to its intestinal solubility (bioavailability), which in turn is determined by its physicochemical properties. It is still not clear which characteristics are more relevant in affecting solubility and bioavailability of mineral sources. Zinc oxide (ZnO) is a common feed additive used to supplement zinc in the diet of monogastric animals. However, different sources have shown different responses on animal bioavailability. This study hypothesized that different sources of feed grade ZnO have various physicochemical features that lead to distinct bioavailability values. Feed grade ZnO samples collected from the feed industry worldwide and characterized for their physicochemical features were tested in broilers and their zinc bioavailability determined. A total of 135 male Cobb broiler chickens were fed a standard starter diet from day 1 after hatching up to day 7. At day 8, animals were allocated in individual cages and fed one of the following dietary treatments during 15 days: a basal diet with 23.5 ppm of zinc and 7 diets with supplemented ZnO or zinc sulphate (ZnSO4) at 6 or 12 ppm. Different sources of ZnO showed an effect of Zn solubility in the stomach and Zn supplementation influenced total Zn in the ileum. The bioavailability of the different sources varied from 49 to 160% compared to the ZnSO4 reference. Aggregate size of particles seems to explain a large variability in the bioavailability of the different sources tested in broilers. In conclusion, physicochemical properties of Zn oxide can partly explain the variability observed in terms of Zn biological value.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers

Cardoso

Romeo²,

Durosoy³

et al. 2021

British Poultry Science

View full text Add to dashboard Cite

show abstract

“…The dissolution levels of ZnO were highly dependent on the concentrations and physicochemical properties of the materials tested. Density, agglomerate/aggregate size, and specific surface area seem to be the important physicochemical characteristics of ZnO affecting the dissolution kinetics [ 22 ]. The size-dependent dissolution of ZnO NPs has been well reported, showing that the dissolution levels increased as the particle size decreased [ 23 , 24 ].…”

Section: Dissolution Properties Of Zno Npsmentioning

confidence: 99%

Food Additive Zinc Oxide Nanoparticles: Dissolution, Interaction, Fate, Cytotoxicity, and Oral Toxicity

Youn

Choi

2022

IJMS

View full text Add to dashboard Cite

Food additive zinc oxide (ZnO) nanoparticles (NPs) are widely used as a Zn supplement in the food and agriculture industries. However, ZnO NPs are directly added to complex food-matrices and orally taken through the gastrointestinal (GI) tract where diverse matrices are present. Hence, the dissolution properties, interactions with bio- or food-matrices, and the ionic/particle fates of ZnO NPs in foods and under physiological conditions can be critical factors to understand and predict the biological responses and oral toxicity of ZnO NPs. In this review, the solubility of ZnO NPs associated with their fate in foods and the GI fluids, the qualitative and quantitative determination on the interactions between ZnO NPs and bio- or food-matrices, the approaches for the fate determination of ZnO NPs, and the interaction effects on the cytotoxicity and oral toxicity of ZnO NPs are discussed. This information will be useful for a wide range of ZnO applications in the food industry at safe levels.

show abstract

“…We began by studying the dissolution dynamics of inorganic nanoparticles in the presence of slow acid generators. For our preliminary investigation, we chose zinc oxide ZnO nanoparticles as a model system for its great relevance [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ] and commercial availability. As slow acid generators, we chose a lactone, δ-gluconolactone (GL), and a sultone, 1,3-propanesultone (PrS).…”

Section: Introductionmentioning

confidence: 99%

Dissolution of Zinc Oxide Nanoparticles in the Presence of Slow Acid Generators

et al. 2022

View full text Add to dashboard Cite

We describe a preliminary investigation of the dissolution dynamics of zinc oxide nanoparticles in the presence of cyclic esters (δ-gluconolactone and propanesultone) as slow acid generators. The particles dissolution is monitored by means of turbidimetry and correlated with the evolution of pH over time. The results could be of interest for the design of chemically programmable colloidal systems.

show abstract

Dissolution kinetics of zinc oxide and its relationship with physicochemical characteristics

Cited by 32 publications

References 45 publications

Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers

Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers

Food Additive Zinc Oxide Nanoparticles: Dissolution, Interaction, Fate, Cytotoxicity, and Oral Toxicity

Dissolution of Zinc Oxide Nanoparticles in the Presence of Slow Acid Generators

Contact Info

Product

Resources

About