Dissolution kinetics or pure mass transfer? A mechanistic study of dissolution

Kaunisto, Erik; Marucci, Mariagrazia; Axelsson, Anders

doi:10.1002/aic.12475

Cited by 9 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiments, the interface is directly observed and no hydrodynamical assumption is needed. But discussions about the dissolution measurement methodology are still active, and further experiments are still highly desirable.…”

Section: Resultsmentioning

confidence: 99%

“…For hard minerals like aluminosilicates, dissolution is so slow that it drives the whole kinetics and the mass transport contribution can be neglected . But for softer minerals like carbonates and sulfates, or for organic compounds, dissolution, diffusion, and convection timescales are of the same order of magnitude and their respective contribution can be difficult to distinguish …”

Section: Diffusion‐ and Convection‐free Dissolution Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Pure dissolution kinetics of anhydrite and gypsum in inhibiting aqueous salt solutions

Pachon-Rodriguez

Colombani

2012

AIChE Journal

View full text Add to dashboard Cite

In the context of the study of the wet creep of plasterboards, digital holographic interferometry measurements have been performed of the dissolution of gypsum of various quarries in water and in aqueous solutions of salts inhibiting dissolution and of the dissolution of anhydrite in water. This technique is carried out in still water and permits to observe directly the reacting solid-liquid interface. Therefore, contrary to standard bulk measurements, the pure dissolution rate constants, free from any mass transport contribution, have been measured. These rate constants are similar for the cleavage face of the various gypsums. Thanks to their faculty of complexing the surface calcium ions, the investigated phosphate and phosphonate salts inhibit dissolution and reduce the dissolution rate constant of up to more than one order of magnitude. This strong influence may explain their anticreep role in plasterboards.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Diffusion‐ and Convection‐free Dissolution Measurementsmentioning

confidence: 99%

Pure dissolution kinetics of anhydrite and gypsum in inhibiting aqueous salt solutions

Pachon-Rodriguez

Colombani

2012

AIChE Journal

View full text Add to dashboard Cite

show abstract

“…lower than the calculated ones, contrary to the close agreement claimed by the authors. This most 29 Kaunisto et al 45 1.30 (±0.07) Banerjee et al 42…”

Section: Generalization To General Forced Flow Systemsmentioning

confidence: 90%

“…Humphreys et al 43 5.129 (0.01 N HCl) 45 3. Converted from the variability value (0.005 mm 2 /s) reported by Kestin et al 47 4.…”

Section: 131mentioning

confidence: 99%

Dissolution mechanisms

Yang¹

View full text Add to dashboard Cite

The dissolution behavior of a drug substance is an important part of its bioavailability. Three solid dissolution mechanisms are recognized: transport control, interface control and mixedkinetic control. The mixed-kinetic control mechanism is not well studied as the majority of dissolution phenomena in pharmaceutical research are assumed to be transport-controlled. A phenomenological model for mixed-kinetic control was developed in which the interfacial step comprises molecular detachment and re-deposition and is described by chemical kinetic theory. This model encompasses interface control and transport control as limiting cases. Experimental studies on three organic compounds showed that they dissolved by transport control at 37°C, but exhibited certain degrees of interface control at lower temperatures (10°C and 3°C), which, according to the model, indicates that reducing the dissolution temperature slowed down re-deposition more than transport. Using mathematical approaches derived from the model, up to 27% interface control was calculated from the experimental results. The second experimental investigation showed significant degrees of interface control in benzoic acid dissolution in sodium dodecyl sulfate (NaDS) solutions at 25°C. The dissolution behavior was well described by the mixed-kinetic control model and up to 73% interface control was calculated. An extension of the model was proposed to describe a potential micelle-interface interaction mechanism indicated by the model-fitted parameters. The third investigation showed that FD&C Blue #1, a water-soluble dye, inhibited sulfathiazole dissolution in acidic media but not in water. The inhibition was attributed to the blocking of dissolution sites by dye adsorption. A potential pH-dependent adsorption mechanism was proposed in which protonation at sulfathiazole solid surface gives rise to preferential dye adsorption on detachment rates and thus reduced dissolution rates. v

show abstract

The role of the solid-solution interface in the dissolution of benzoic acid

Yang

et al. 2015

Chemical Engineering Science

View full text Add to dashboard Cite

Dissolution kinetics or pure mass transfer? A mechanistic study of dissolution

Cited by 9 publications

References 26 publications

Pure dissolution kinetics of anhydrite and gypsum in inhibiting aqueous salt solutions

Pure dissolution kinetics of anhydrite and gypsum in inhibiting aqueous salt solutions

Dissolution mechanisms

The role of the solid-solution interface in the dissolution of benzoic acid

Contact Info

Product

Resources

About