Dissolution, Stability, and Absorption Characteristics of Dicumarol in Polyethylene Glycol 4000 Solid Dispersions

Crystallization Tendency of Active Pharmaceutical Ingredients Following Rapid Solvent Evaporation—Classification and Comparison with Crystallization Tendency from Under cooled Melts

“…There are numerous examples in the literature describing the stability and/or stabilization of amorphous pharmaceuticals 18–20. Typically, the crystallization behavior of only one or a few compounds is reported in such studies.…”

Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000

“…In fact, 10% w/w triamterene solid dispersion gave less problems derived from the interindividual variation when we talk about relationship between drug and animal response. Time (h) 2 Hydric urinary volume (mL) o weight polymer in the gastrointestinal lumen may alter absorption by viscosity effects, solvent effects, and drug complexation (12). In our case, dissolution behaviour and further absorption has been explained by means of the humectant effect of PEG 4000, which provides a reduction in aggregation and agglomeration of drug particles.…”

Crystallinity and Dissolution Rate of Tolbutamide Solid Dispersions Prepared by the Melt Method

“…In 1961, Sekiguchi and Obi (1) became the first researchers to propose the use of solid dis- persions to increase the dissolution rate and oral absorption of drugs. In recent reports, (2)(3)(4)(5)(6), the great variety of drug molecules and water-soluble carriers used to prepare solid dispersions have been reviewed.…”