Dissolvable layered microneedle patch containing 5-fluorouracil for localized treatment of oral carcinoma

Matta, Asha; Janardhanam, Leela Sai Lokesh; Venuganti, Venkata Vamsi Krishna

doi:10.1007/s12039-023-02149-2

Cited by 5 publications

(1 citation statement)

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“…Confocal microscopy and stereomicroscope also demonstrated that DOX could diffuse into porcine oral tissues deep and laterally over an area of 1 × 1 cm 2 [ 125 ]. Another research group developed a cellulose MN patch for localized chemotherapeutic agent 5-fluorouracil delivery to the buccal mucosa to treat oral carcinoma [ 126 ]. A photosensitizer-loaded microneedle patch was developed for targeted phototherapy in oral carcinoma.…”

Section: Applications Of Hydrogel-forming Microneedles In Dental Therapymentioning

confidence: 99%

Hydrogel-Forming Microneedles with Applications in Oral Diseases Management

et al. 2023

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Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination, saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a location-specific, minimally invasive, and retentive approach. Hydrogel-forming microneedles (HFMs) have emerged for dental diagnostics and therapeutics. HFMs penetrate the stratum corneum, undergo swelling upon contact, secure attachment, and enable sustained transdermal or transmucosal drug delivery. Commonly employed polymers such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone are crosslinked with tartaric acid or its derivatives while incorporating therapeutic agents. Microneedle patches provide suture-free and painless drug delivery to keratinized or non-keratinized mucosa, facilitating site-specific treatment and patient compliance. This review comprehensively discusses HFMs’ applications in dentistry such as local anesthesia, oral ulcer management, periodontal treatment, etc., encompassing animal experiments, clinical trials, and their fundamental impact and limitations, for example, restricted drug carrying capacity and, until now, a low number of dental clinical trial reports. The review explores the advantages and future perspectives of HFMs for oral drug delivery.

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Section: Applications Of Hydrogel-forming Microneedles In Dental Therapymentioning

confidence: 99%