Dissolvable microneedle fabrication using piezoelectric dispensing technology

Allen, Evin A.; O’Mahony, Conor; Cronin, Michael F.; O'mahony, T. A. F.; Moore, Anne; Crean, Abina M.

doi:10.1016/j.ijpharm.2015.12.052

Cited by 61 publications

(38 citation statements)

References 39 publications

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“…[86] Currently, such technique has been main utilized to coat pre-fabricated microneedles with drugs for the personalized and combined drug loading. [87,88] Photopolymerization-based technique refers to the fabrication of 3D models by selectively polymerization of photo-sensitive polymers under the laser/light irradiation. Such technique could fabricate polymeric microneedles by consistent layer-by-layer polymerization of UV-sensitive polymers through the photopolymerization curing process.…”

Section: Methods For the Fabrication Of Polymeric Microneedlesmentioning

confidence: 99%

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Liu

Luo

Xing

2020

Advanced Therapeutics

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Transdermal drug delivery is a crucial extension of drug administration routes and has been widely acknowledged as an alternative way to traditional oral administration and subcutaneous injections due to the advantages such as increased dosage efficacy, decreased systemic side effect, and improved patient compliance. The past few decades have witnessed biomedical applications of microneedles in various cutting‐edge fields. Microneedles are needles with micron‐scale length which can pierce the epidermis of the skin in a minimally invasive manner for transdermal drug delivery. Compared with inorganic and metal microneedles, polymeric microneedles have attracted more attention because of their superior biocompatibility, nontoxicity, and biodegradability. In this review, the state‐of‐art and future biomedical applications of polymeric microneedles are summarized. First of all, a brief introduction to the polymeric microneedles, including types of polymeric microneedles and methods for the fabrication is included. Then the biomedical applications of polymeric microneedles in transdermal drug delivery and diagnosis are summarized in detail. Finally, discussions on the current limitations and future perspectives of polymeric microneedles are provided.

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Section: Methods For the Fabrication Of Polymeric Microneedlesmentioning

confidence: 99%

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Liu

Luo

Xing

2020

Advanced Therapeutics

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“…Both are approved as inactive materials by FDA for parenteral drug products. Other materials include poly(vinylalcohol) (PVA) ( 42 ), poly(vinylpyrrolidone) (PVP) ( 43 ), methylvinylether-co-maleic anhydride (PMVE/MA) (Gantrez AN-139®) ( 44 , 45 ) and low molecular weight sugars like maltose ( 46 , 47 ) and trehalose ( 48 ). dMNs have also been prepared from biodegradable polymers such as polylactic-co-glycolic acid (PLGA) ( 46 ), polylactic acid (PLA) ( 49 ) and polyglycolic acid (PGA) ( 50 ).…”

Section: Materials and Manufacturing Methodsmentioning

confidence: 99%

“…However, due to their slow dissolution rate in skin and a preparation method using high temperatures ( 34 ) and organic solvents, these polymers are less suitable as matrix material. The back-plate of the dMN patch can be made by using the same ( 51 ) or different materials ( 30 , 42 ) as the needles. Furthermore, the back-plate can be reinforced or the ease of handling can be increased by applying an adhesive tape ( 38 , 42 , 52 – 54 ).…”

Section: Materials and Manufacturing Methodsmentioning

confidence: 99%

Dissolving Microneedle Patches for Dermal Vaccination

et al. 2017

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The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or needle re-use). This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen. The microneedle patch fabrication techniques and their challenges are discussed as well as the microneedle characterization methods and antigen stability aspects. The immunogenicity of antigens formulated in dissolving microneedles are addressed. Finally, the early clinical development is discussed.

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“…In general, MNs can be made of a wide variety of materials. Until now scientists have developed silicon MNs [9,26,27], glass MNs [28][29][30][31], ceramic MNs [32,33] metal MNs [34][35][36][37], hydrogel MNs [38,39], polymer MNs [40][41][42][43][44][45][46][47] and sugar MNs [48][49][50], etc. Because the micro-fabrication techniques for silicon have been developed for several decades, most of the MNs were made of silicon in the early developing stage.…”

Section: Categorized By Materialsmentioning

confidence: 99%

Microneedle, bio-microneedle and bio-inspired microneedle: A review

2017

Journal of Controlled Release

345

198

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Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs. Secondly, researches on inserting behavior and mechanical performances of MNs are discussed. Thirdly, literatures on the drug delivery and the pain resulted from the insertion of MNs are overviewed. Finally, some bio-microneedles and bio-inspired MNs are introduced.

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Dissolvable microneedle fabrication using piezoelectric dispensing technology

Cited by 61 publications

References 39 publications

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Dissolving Microneedle Patches for Dermal Vaccination

Microneedle, bio-microneedle and bio-inspired microneedle: A review

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