Abstract. The data set presented here consists of 273 Conductivity-Temperature-Depth (CTD) stations, as well as 2034 sampled data points in the water column, where dissolved inorganic nutrients have been measured, that were collected during 12 summer oceanographic cruises (BANSIC series) in the Sicily Channel (Central Mediterranean Sea), between 2010 and 2021. The quality of the CTD dataset is ensured by regular sensor calibrations, an accurate control process adopted during the acquisition, processing and post-processing phases. The quality of the biogeochemical dataset is ensured by the adoption to best-practices analytical and sampling methods. This data collection fills up a gap of information in the Sicily Channel, i.e. a key area where complex water mass exchange processes involve the transfer of physical and biogeochemical properties between the Eastern and the Western Mediterranean. The available dataset will be useful to evaluate the long-term variability on a wide spatial scale, supporting studies on the evolution of the Mediterranean circulation and its peculiar biogeochemistry, as well as on the physical and biogeochemical modeling of this area.