Objective. This study aimed to investigate the clinical effect of ultrasound-guided transradial catheterization (TRC) for ICU patients with shock. Methods. 120 shock patients registered in the ICU of our hospital from January 2019 to June 2022 were selected for prospective study. The control group (60 patients) were treated with palpation-guided TRC. The observation group was treated with ultrasound-guided TRC and was divided into the internal puncture group (internal TRC) and external puncture group (external TRC), with 30 cases in each. The first attempt success rate, total success rate, operation duration, complication, measurement of radial artery, and VAS scores were compared in these groups. Results. The success rate was higher in the observation group than in the control group (
P
<
0.05
), and higher in the internal puncture group than in the external puncture group (
P
<
0.05
). The first attempt success rate was significantly higher in the observation group than in the control group (
P
<
0.05
), with no significant difference in between (
P
>
0.05
). The number of attempts and operation duration were lower in the observation group than in the control group (
P
<
0.05
), with significantly more operation duration in the internal puncture group than in the external puncture group (
P
<
0.05
) and no significant difference in the number of attempts (both
P
>
0.05
). The complication rate was significantly lower in the observation group than in the control group (
P
<
0.05
) and there was no significant difference in between (
P
>
0.05
). The radial artery diameter, cross-sectional area, and depth from the skin in the observation group were larger than those in the control group (
P
<
0.05
) and there was no significant difference in between (
P
>
0.05
). At 1, 6, 24, and 48 h after the surgery, the observation group showed lower VAS scores than the control group (
P
<
0.05
). Conclusion. The ultrasound-guided TRC reduced the number of attempts, the complication rates, and the operation duration. For patients with shock, if Doppler ultrasound cannot detect blood flow, the success rate in the observation group was higher than that in the control group, and its advantage is worthy of promotion in severe patients.