Distant Soft Tissue Metastases: A Series of 30 New Patients and 91 Cases From the Literature

Damron, Timothy A.; Heiner, John P.

doi:10.1007/s10434-000-0526-7

Cited by 165 publications

(164 citation statements)

References 43 publications

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“…Although the CT presentation did not conform to the typical skeletal muscle metastasis, which is rather rare, this suspicious diagnosis could not be ruled out solely relying on the imaging findings, particularly considering that NSCLC is prone to distant metastases (7). The differential diagnosis should include intramuscular metastasis and primary soft-tissue tumors, as each can arise from the psoas muscle and cause lumbar pain (13)(14)(15). Furthermore, the definition of the nature of the muscle abnormality would be of great value, as the correct diagnosis would affect the following clinical management and vary the prognosis of the patient.…”

Section: Discussionmentioning

confidence: 99%

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Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

et al. 2015

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Abstract. Intramuscular myxoma (IMM) as a rare soft-tissue tumor arising from the muscles is completely benign. When IMM accompanies malignance, it may be misdiagnosed as muscle metastasis, and for this extremely rare concurrence, the subsequent treatment would vary accordingly. The current study presents, to the best of our knowledge, the first case of non-small cell lung cancer (NSCLC) concomitant with IMM mimicking skeletal muscle metastasis. A 64-year-old female was hospitalized with a history of chest discomfort and right lumbar pain that had persisted for four months. The computed tomography scan showed a lesion in the left upper lobe of the lung and the right psoas, respectively. Serum biomarkers for NSCLC were abnormal. A presumptive clinical diagnosis was compatible with left NSCLC and right psoas muscle metastasis (cT2aN3M1b, stage Ⅳ). Stage Ⅳ lung cancer would receive palliative treatment. However, the final diagnosis of synchronous left lung squamous cell carcinoma (cT2aN3M0, stage ⅢB) and IMM in the right psoas was confirmed by biopsy. The patient therefore underwent definitive chemoradiotherapy for lung carcinoma, and conservative treatment, including analgesics, for IMM. The diagnosis process for a malignant neoplasm concomitant with IMM is not straightforward due to a lack of clinical experience, and it significantly affects the tumor staging and subsequent treatment strategy. The present case suggests that IMM should be included in the differential diagnosis when an abnormal intramuscular lesion concomitant with malignancy is identified. The value of histopathological diagnosis prior to definitive treatment also requires highlighting.

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Section: Discussionmentioning

confidence: 99%

“…The most frequent clinical manifestation of muscle metastasis is local pain, with or without a palpable mass (15). In individual cases, skeletal muscle metastasis from lung cancer has even presented as the initial clinical manifestation, so it may be easily misdiagnosed, particularly when the primary tumor is unknown (25).…”

Section: Discussionmentioning

confidence: 99%

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

et al. 2015

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“…The commonly reported primary malignancies that may metastasize to the skeletal muscle are lung cancer, renal cell carcinoma and gastrointestinal tumours and genital tumours, but rarely melanoma [13][14][15][16][17][18][19][20][21][22] . The best epidemiological evidence for skeletal muscle metastasis reported to date was from an 8-year retrospective review of Surov et al They reported an incidence of 1.2% out of 5,170 patients that presented with metastatic solid malignancies, and most of them (91.8%) already had widespread metastases when the distal skeletal muscle was found to be invaded, hence it's uncommon to see isolated intramuscular metastases without spreading to other distant organs as in our case.…”

Section: Discussionmentioning

confidence: 99%

“…The common clinical scenario in which skeletal muscle metastasis is detected is the presenting symptom of a painful mass (usually more than 5 cm in diameter) [13][14][15][16][17][18][19][20][21][22] . This may be an important clue to suggest metastasis rather than a primary sarcoma of soft tissue, which is more commonly seen but typically present as painless soft tissue masses [14,20] .…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle metastasis from malignant melanoma: a case report and review of the literature

Zhu

Selvarajan

Sittampalam

et al. 2015

CRCP

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“…Surov et al reported a series of 61 patients with skeletal muscle metastasis from a population of 5170 patients seen during a 7-year period [51]. Damron and Heiner described a series of 30 patients and identified an additional 91 cases from the literature [8]. Other, smaller series exist, including a series of 12 patients described by Tuoheti et al [53], and 11 patients described by Yoshimura et al [58].…”

Section: Discussionmentioning

confidence: 99%

Orthopaedic Case of the Month: A 72-year-old Man With a Painful Flexion Contracture of the Left Thigh

Cafferky

Malone

Bowen

2013

Clinical Orthopaedics &Amp; Related Research

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A 72-year-old man presented with a 48-hour history of increasing left posterior thigh pain and a progressive left knee flexion contracture. Physical examination revealed that he recently had a left below knee amputation. The stump was healing well. He had a firm posterior thigh with a woody consistency extending from the popliteal fossa proximally to the midposterior left thigh. On attempted passive extension of the left knee, there was exquisite pain in the posterior thigh.Four weeks before his current presentation for the left posterior thigh pain, he had been admitted to our institution with a 1-week history of worsening abdominal pain, nausea, and vomiting. The patient had general surgery and gastroenterology consultations. Physical examination of his abdomen revealed a soft, nondistended abdomen with hyperactive bowel sounds. He had tenderness in the epigastrium, umbilical region, and right lower quadrant. There were no palpable masses or organomegaly. Imaging of the abdomen revealed a high-grade small bowel obstruction with a transition point seen in the right lower quadrant. The patient was treated with a small bowel follow-through and colonoscopy that led to an exploratory laparotomy with resection of a mass in the distal ileum. Pathologic examination of the small bowel mass showed a metastatic Stage IV carcinoma. Further immunohistochemical and tumor marker analyses suggested a primary neoplasm of gastric or esophageal origin. Staging with a CT of the chest, abdomen, and pelvis showed no other lesions of the viscera.During the same hospital admission for his small bowel obstruction, orthopaedics was consulted for a chronic 4-cm 9 2-cm wound of the left heel that had been present for 6 months. On evaluation, he also had chronic osteomyelitis of the left calcaneus and a left knee flexion contracture of 30°with mild tenderness to palpation about the knee. Radiographs of the left knee showed chronic degenerative changes. No additional or advanced imaging of his left knee or thigh was obtained at that time, as he had a relatively painless knee flexion contracture. His surgical history revealed that 2 years before his current presentation he had undergone a left Chopart amputation for dysvascular forefoot wounds. Although he did not have a diagnosis of diabetes, he had a history of peripheral vascular disease with neuropathy secondary to heavy tobacco use. As treatment for his chronic heel wound, the patient underwent a left below knee amputation 5 days after his exploratory laparotomy. Intraoperatively after the below knee amputation, he was treated with an intraarticular

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Distant Soft Tissue Metastases: A Series of 30 New Patients and 91 Cases From the Literature

Cited by 165 publications

References 43 publications

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

Skeletal muscle metastasis from malignant melanoma: a case report and review of the literature

Orthopaedic Case of the Month: A 72-year-old Man With a Painful Flexion Contracture of the Left Thigh

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