2016
DOI: 10.1172/jci.insight.86292
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Distinct activation thresholds of human conventional and innate-like memory T cells

Abstract: Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B. To better understand each subset’s unique contributions to immunity and pathology, we interrogated inflammation- and TCR-driven activation requirements using human memory CD8+ T and MAIT cells isolated from blood and mucosal tissue biopsies in ex vivo functional assays and … Show more

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Cited by 122 publications
(172 citation statements)
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“…In addition, high expression of receptors for IL-18 and IL-12 (9,31,32) provides MAIT cells with the capacity to respond to antigen-presenting cell (APC)-derived cytokines, recently shown to be important for TCR-mediated activation (33,34), as well as to MR1-independent innate responses (35,36). Given that the activating antigens identified thus far are of bacterial or fungal origin, MR1-independent responses are probably important for the involvement of MAIT cells in viral immunopathogenesis in diseases caused by HIV, HCV, dengue virus, and influenza virus (37)(38)(39)(40).…”
mentioning
confidence: 99%
“…In addition, high expression of receptors for IL-18 and IL-12 (9,31,32) provides MAIT cells with the capacity to respond to antigen-presenting cell (APC)-derived cytokines, recently shown to be important for TCR-mediated activation (33,34), as well as to MR1-independent innate responses (35,36). Given that the activating antigens identified thus far are of bacterial or fungal origin, MR1-independent responses are probably important for the involvement of MAIT cells in viral immunopathogenesis in diseases caused by HIV, HCV, dengue virus, and influenza virus (37)(38)(39)(40).…”
mentioning
confidence: 99%
“…Expression of PLZF is sufficient to induce acquisition of effector memory-like properties in conventional T-cells[38,39] and is required for the innate-like effector function of NKT cells [40,41] and certain gamma delta T-cells[42]. Once activated, MAIT cells isolated from the blood (or stimulated in the presence of other peripheral blood mononuclear cells, PBMCs) secrete IFNγ, TNFα and express the cytolytic molecule granzyme B[12,28,31,43,44]. Overall, it has become clear that there is more heterogeneity in the MAIT cell population than initially appreciated[45].…”
Section: Mait Cell Subsets Phenotypes and Function In Bloodmentioning
confidence: 99%
“…Finally, MAIT cells in the blood can be divided into different subsets based on CD8 and CD4 co-receptor expression. The relationship of these subsets is unclear, but single cell gene expression analysis from the two major MAIT subsets, CD8 + and CD8 − (CD4 − ) cells, isolated from the blood demonstrated distinct transcriptional differences[44] and their respective frequencies can change independently following infection[46]. …”
Section: Mait Cell Subsets Phenotypes and Function In Bloodmentioning
confidence: 99%
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