Distinct Aging Effects on Motion Repulsion and Surround Suppression in Humans

Deng, Hu; Chen, Weiying; Kuang, Shenbing; Zhang, Tao

doi:10.3389/fnagi.2017.00363

Cited by 13 publications

(12 citation statements)

References 55 publications

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“…We found that spatial suppression decreased with age in healthy controls-an effect consistently found in previous studies (Betts et al 2005;Betts, Sekuler, and Bennett 2009;Yazdani et al 2015;Zhuang et al 2017;Pitchaimuthu et al 2017;Tadin et al 2019;Deng et al 2017;Karas and McKendrick 2012) . Here, we found that this age-mediated perceptual alteration also occurs in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 89%

Spatial suppression and sensitivity for motion in schizophrenia

Linares

Amoretti

Marin-Campos

et al. 2019

Preprint

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Perceptual spatial suppression is a phenomenon in which the perceived strength of a stimulus in some region of the space is reduced when the stimulus is surrounded by other stimuli. For contrast perception, several studies suggest that spatial suppression is reduced in patients with schizophrenia. For motion perception, only one study has been conducted in a cohort of 16 patients, suggesting that spatial suppression is reduced. It is unknown, however, whether this reduction is related to the lower intelligence quotient (IQ) that schizophrenic patients usually show; as there is evidence that spatial suppression for motion increases with IQ in healthy individuals. Here, we sought to determine the spatial suppression for motion in a larger cohort of 32 patients with schizophrenia and controlling the results for the IQ of patients. We found a weakened spatial suppression in patients with schizophrenia, consistent with the previous study (effect size g = 0.47 with CI = [0.055, 0.88], combining the previous and our study). For comparison, we performed a meta-analysis on spatial suppression for contrast (7 studies) and found a similar effect size, but with higher evidence (g = 0.56 with CI = [0.40, 0.72]). We found that patients had a lower IQ than controls, but this difference did not explain their weaker spatial suppression. Further, we found that spatial suppression of patients, but not controls increased with their IQ and decreased with age in both groups. Finally, as we estimated lapses of attention, we could estimate motion sensitivity and found that it was decreased in patients. We discuss how this reduced spatial suppression and sensitivity might be related to glutamatergic hypofunction in schizophrenia.

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Section: Discussionsupporting

confidence: 89%

Spatial suppression and sensitivity for motion in schizophrenia

Linares

Amoretti

Marin-Campos

et al. 2019

Preprint

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“…Meanwhile, it is widely accepted that our brain is highly adaptive and flexible in processing and interpreting the incoming visual information (e.g., see Deng, Chen, Kuang, & Zhang, ; Di Luca, Ernst, & Backus, ; Haijiang, Saunders, Stone, & Backus, ; Kaliuzhna, Prsa, Gale, Lee, & Blanke, ; Kuang & Zhang, ). The same work of art is differentially perceived and appreciated by artists and nonartists who have little artistic training.…”

mentioning

confidence: 99%

Adaptive heading performance during self‐motion perception

2019

Self Cite

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Previous studies have documented that the perception of self-motion direction can be extracted from the patterns of image motion on the retina (also termed optic flow). Self-motion perception remains stable even when the optic-flow information is distorted by concurrent gaze shifts from body/eye rotations. This has been interpreted that extraretinal signals-efference copies of eye/body movements-are involved in compensating for retinal distortions. Here, we tested an alternative hypothesis to the extraretinal interpretation. We hypothesized that accurate self-motion perception can be achieved from a purely optic-flow-based visual strategy acquired through experience, independent of extraretinal mechanism. To test this, we asked human subjects to perform a self-motion direction discrimination task under normal optic flow (fixation condition) or distorted optic flow resulted from either realistic (pursuit condition) or simulated (simulated condition) eye movements. The task was performed either without (pre-and posttraining) or with (during training) the feedback about the correct answer. We first replicated the previous observation that before training, direction perception was greatly impaired in the simulated condition where the optic flow was distorted and extraretinal eye movement signals were absent. We further showed that after a few training sessions, the initial impairment in direction perception was gradually improved. These results reveal that behavioral training can enforce the exploitation of retinal cues to compensate for the distortion, without the contribution from the extraretinal signals. Our results suggest that self-motion perception is a flexible and adaptive process which might depend on neural plasticity in relevant cortical areas.

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“…The cortical connectivity deficit is also compatible with a previous finding showing a decline in volume in many white matter regions of the AD brain (Kuang, ; Salat et al ., ). In a wider perspective, dysfunctions of cortical connections, especially those inhibitory micro‐circuit, are linked to perceptual and cognitive impairments identified in ageing (Betts, Taylor, Sekuler, & Bennett, ; Deng, Chen, Kuang, & Zhang, ) and several neurological disorders including AD and schizophrenia (Anticevic et al ., ; Festa et al ., ; Kuang, , ).…”

Section: Discussionmentioning

confidence: 99%

Motion‐induced position mis‐localization predicts the severity of Alzheimer's disease

Song

Wang

2019

Journal of Neuropsychology

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Patients with Alzheimer's disease (AD) often exhibit motion processing deficits. It is unclear whether the localization of moving objectsa perceptual process tightly linked to motionis impaired or intact in AD. In this study, we used the phenomenon of illusory shift of position induced by motion as a behavioural paradigm to probe how the spatial representation differs between AD patients and healthy elderly controls. We measured the magnitudes of motion-induced position shift in a group of AD participants (N = 24) and age-matched elderly observers (N = 24). We found that AD patients showed weakened position mis-localization, but only for motion stimuli of slow speeds. For fast motion, the position mis-localization did not differ significantly between groups. Furthermore, we showed that the magnitudes of position mis-localization can predict the severity of AD; that is, patients with more severe symptoms had less preserved position mis-localization. Our results suggest that AD pathology impacts not only motion processing per se, but also the perceptual process related to motion such as the localization of moving objects.

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Distinct Aging Effects on Motion Repulsion and Surround Suppression in Humans

Cited by 13 publications

References 55 publications

Spatial suppression and sensitivity for motion in schizophrenia

Spatial suppression and sensitivity for motion in schizophrenia

Adaptive heading performance during self‐motion perception

Motion‐induced position mis‐localization predicts the severity of Alzheimer's disease

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