Distinct metabolic shifts occur during the transition between normoxia and hypoxia in the hybrid and its maternal abalone

Shen, Yawei; Zhang, Ying; Xiao, Qizhen; Gao, Yang; Wang, Yi; Pang, Gewen; Huang, Zekun; Yu, Feng; Luo, Xuan; Ke, Caihuan; Wang, You

doi:10.1016/j.scitotenv.2021.148698

Cited by 24 publications

(7 citation statements)

References 44 publications

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“…In this study, the intestinal metabolome of abalone in the high- and low-FE groups was analyzed, and a total of 344 metabolites were identified. The number of metabolites identified was similar to previous studies on abalone ( Shen et al, 2021 ), and major metabolites were identified, including taurine, citrate, succinate, lactate, glutamate, glutamine, and L -carnitine, thus confirming the reliability of our results. Arginine is involved in RNA synthesis and protein glycosylation, and it is an essential amino acid for cellular function ( Li et al, 2018 ).…”

Section: Discussionsupporting

confidence: 90%

Exploring the Intestinal Microbiota and Metabolome Profiles Associated With Feed Efficiency in Pacific Abalone (Haliotis discus hannai)

Shen

et al. 2022

Front. Microbiol.

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Feed efficiency (FE) is critical to the economic and environmental benefits of aquaculture. Both the intestines and intestinal microbiota play a key role in energy acquisition and influence FE. In the current research, intestinal microbiota, metabolome, and key digestive enzyme activities were compared between abalones with high [Residual feed intake (RFI) = −0.029] and low FE (RFI = 0.022). The FE of group A were significantly higher than these of group B. There were significant differences in intestinal microbiota structures between high- and low-FE groups, while higher microbiota diversity was observed in the high-FE group. Differences in FE were also strongly correlated to variations in intestinal digestive enzyme activity that may be caused by Pseudoalteromonas and Cobetia. In addition, Saprospira, Rhodanobacteraceae, Llumatobacteraceae, and Gaiellales may potentially be utilized as biomarkers to distinguish high- from low-FE abalones. Significantly different microorganisms (uncultured beta proteobacterium, BD1_7_clade, and Lautropia) were found to be highly correlated to significantly different metabolites [DL-methionine sulfoxide Arg-Gln, L-pyroglutamic acid, dopamine, tyramine, phosphatidyl cholines (PC) (16:0/16:0), and indoleacetic acid] in the high- and low-FE groups, and intestinal trypsin activity also significantly differed between the two groups. We propose that interactions occur among intestinal microbiota, intestinal metabolites, and enzyme activity, which improve abalone FE by enhancing amino acid metabolism, immune response, and signal transduction pathways. The present study not only elucidates mechanisms of variations in abalone FE, but it also provides important basic knowledge for improving abalone FE by modulating intestinal microbiota.

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Section: Discussionsupporting

confidence: 90%

Exploring the Intestinal Microbiota and Metabolome Profiles Associated With Feed Efficiency in Pacific Abalone (Haliotis discus hannai)

Shen

et al. 2022

Front. Microbiol.

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“…latipes, Sillago sihama, G. aculeatus, Gillichthys mirabilis, Fundulus grandis, Micropogonias undulatus, and Cyprinus carpio. , Pathways that are closely related to the glutamate–glutamine cycle, an important metabolic process in hypoxia responses of abalone mentioned in our previous study, including nicotinate and nicotinamide metabolism; aminoacyl-tRNA biosynthesis; valine, leucine, and isoleucine degradation; ABC transporter; glutamatergic synapse; circadian entrainment; and long-term depression, are also enriched by up-regulated and down-regulated SDEmRNAs in this study.…”

Section: Discussionmentioning

confidence: 89%

“…lemaneiformis, and feeding was stopped 1 day prior to the experiment. After the acclimation, the hypoxia tolerance of these juvenile abalones was evaluated by exposing them to the hypoxia condition (∼0.56 O 2 mg/L) for 27 h. The extreme hypoxia condition is set according to the dissolved oxygen concentration during one hypoxia event in the abalone farming area (Dongshan, China) . The detached abalone was regarded as dead when no withdrawal response was observed while being touched gently with a dissecting needle every 20 min .…”

Section: Methodsmentioning

confidence: 99%

“…After the acclimation, the hypoxia tolerance of these juvenile abalones was evaluated by exposing them to the hypoxia condition (∼0.56 O 2 mg/L) for 27 h. The extreme hypoxia condition is set according to the dissolved oxygen concentration during one hypoxia event in the abalone farming area (Dongshan, China). 47 The detached abalone was regarded as dead when no withdrawal response was observed while being touched gently with a dissecting needle every 20 min. 54 The survival of juvenile abalones in each group was continuously observed and recorded during 27 h of hypoxia exposure, and Kaplan−Meier survival curve analysis was conducted by the R package survminer (version 0.4.9).…”

Section: Experimental Animalsmentioning

confidence: 99%

“…Abalone is an economically important mollusk globally, whose aquaculture production reached 187,300 tons, with a value of more than 2.222 billion US dollars . Frequent environmental hypoxia events have threatened the long-term economic viability of aquaculture production of abalone . Abalone is a marine gastropod releasing eggs and sperms into the ocean through the holes in the shell by respiratory/sanitation current, and the fertilized egg (zygote) develops to a trochophore and then stays on the bottom after developing to veliger.…”

Section: Introductionmentioning

confidence: 99%

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Divergent Carry-Over Effects of Hypoxia during the Early Development of Abalone

Shen

Gao

Xiao

et al. 2022

Environ. Sci. Technol.

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After being exposed to environmental stimuli during early developmental stages, some organisms may gain or weaken physiological regulating abilities, which would have long-lasting effects on their performance. Environmental hypoxia events can have significant effects on marine organisms, but for breeding programs and other practical applications, it is important to further explore the long-term physiological effects of early hypoxia exposure in economically significant species. In this study, the Pacific abalone Haliotis discus hannai was exposed to moderate hypoxia (∼4 mg/L) from zygote to trochophora, and the assessments of hypoxia tolerance were conducted on the grow-out stage. The results revealed that juvenile abalones exposed to hypoxia at the early development stages were more hypoxiatolerant but with slower weight growth, a phenomenon called the tradeoff between growth and survival. These phenotypic effects driven by the hypoxia exposure were explained by strong selection of genes involved in signal transduction, autophagy, apoptosis, and hormone regulation. Moreover, long non-coding RNA regulation plays an important role modulating carry-over effects by controlling DNA replication and repair, signal transduction, myocardial activity, and hormone regulation. This study revealed that the ability to create favorable phenotypic differentiation through genetic selection and/or epigenetic regulation is important for the survival and development of aquatic animals in the face of rapidly changing environmental conditions.

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Transcriptome Analysis of Different Aquaculture Substrates on the Immune Response of Babylonia areolata

Zhang,

Wang,

et al. 2024

Mar Biotechnol

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Distinct metabolic shifts occur during the transition between normoxia and hypoxia in the hybrid and its maternal abalone

Cited by 24 publications

References 44 publications

Exploring the Intestinal Microbiota and Metabolome Profiles Associated With Feed Efficiency in Pacific Abalone (Haliotis discus hannai)

Exploring the Intestinal Microbiota and Metabolome Profiles Associated With Feed Efficiency in Pacific Abalone (Haliotis discus hannai)

Divergent Carry-Over Effects of Hypoxia during the Early Development of Abalone

Transcriptome Analysis of Different Aquaculture Substrates on the Immune Response of Babylonia areolata

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