2017
DOI: 10.1101/113134
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Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex

Abstract: Processing of olfactory information in the anterior piriform cortex (APC) is widely thought to be nontopographic due to distributed projections from the olfactory bulb (OB). Layer 2 principal neurons in the APC can be divided into 2 subtypes: semilunar (SL) and superficial pyramidal (SP) cells. Although it is known that SL and SP cells receive differential inputs from the OB, little is known about their projection pattern to downstream structures, such as the posterior piriform cortex (PPC). Here we examined f… Show more

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Cited by 9 publications
(12 citation statements)
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“…Second, we assumed that all layer 2 neurons behave similarly, while studies have shown that they comprise semilunar and superficial pyramidal cells which are spatially segregated, differ in the strength of connections they make with incoming LOT axons from the bulb, and might carry out different functions (Calu et al, ; Diodato et al, ; Mazo, Grimaud, Murthy, & Lau, ; Suzuki & Bekkers, ). Thus, the 200,000 APC neurons might not all be engaged in odor coding of the form described in the model.…”
Section: Discussionmentioning
confidence: 99%
“…Second, we assumed that all layer 2 neurons behave similarly, while studies have shown that they comprise semilunar and superficial pyramidal cells which are spatially segregated, differ in the strength of connections they make with incoming LOT axons from the bulb, and might carry out different functions (Calu et al, ; Diodato et al, ; Mazo, Grimaud, Murthy, & Lau, ; Suzuki & Bekkers, ). Thus, the 200,000 APC neurons might not all be engaged in odor coding of the form described in the model.…”
Section: Discussionmentioning
confidence: 99%
“…From all colabeled neurons, the greatest numbers were found in layer ii (78.9%, mean = 101.1 neurons), followed by layers iii and i, respectively (iii: 16.9%, mean = 21.7 neurons; i: 4.2%, mean = 5.5 neurons; F ( 2,7 )=206.47, p <0.0001; Fig 1D ). Importantly, layer ii contains the densest collection of projection neurons (superficial pyramidal neurons and semilunar cells) extending fibers into the OT (Bekkers and Suzuki, 2013; Haberly, 2001; Mazo et al, 2017; Neville and Haberly, 2004; Shipley and Ennis, 1996). While this AAV is, by design, specific for transducing excitatory neurons, we nevertheless confirmed that the neurons infected with AAV and thus expressing ChR2 are indeed glutamatergic by performing anti-VGlut1 immunohistochemistry.…”
Section: Resultsmentioning
confidence: 99%
“…We propose the initial activation of a small subset of superficial PCx neurons can drive reactivation of a stable ensemble of deeper cells, enabling the recovery of robust PCx odor responses despite degraded OB input. Interestingly, PCx cells in deep layer II project back to OB 54,55,57 , suggesting that an accurate representation of the current stimulus is returned to the OB allowing comparison between ongoing input and the retrieved activation patterns, and potentially implementing a predictive loop between OB and PCx to refine odor representations in both regions 39 .…”
Section: Odor Representations In Semilunar and Pyramidal Cellsmentioning
confidence: 99%
“…PCx PYRs as well as more posterior targets such as lateral entorhinal cortex and cortical amygdala54,55 . Because SLs receive little or no input from other PCx excitatory neurons, their responses are minimally affected by local cortical computations41,56 .…”
mentioning
confidence: 99%