Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin

Letra-Vilela, Ricardo; Sánchez‐Sánchez, Ana M.; Rocha, Ana Maia; Martı́n, Vanesa; Branco-Santos, Joana; Puente‐Moncada, Noelia; Santa‐Marta, Mariana; Outeiro, Tiago F.; Antolı́n, Isaac; Rodríguez, Carmen; Herrera, Federico

doi:10.1016/j.mce.2016.07.012

Cited by 9 publications

(7 citation statements)

References 52 publications

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“…Letra-Vilela, R. et al . observed that removal of the N-acetyl group enhances the antioxidant and neuroprotective properties of the maletonin 39 . The elevated level of plasma 5-MT concentrations contributed to scavenge radicals and radical products and functioned as antioxidant against reaction oxygen species (ROS).…”

Section: Discussionmentioning

confidence: 95%

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study

Zeng

Tong

et al. 2017

Sci Rep

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To investigate the metabolic biomarkers of predicting the transition from pre-diabetes (pre-DM) to normal glucose regulation (NGR) and diabetes (DM) in a longitudinal cohort study. 108 participants with pre-DM were followed up for ten years and divided into 3 groups according to different glycemic outcomes. 20 participants progressed to DM, 20 regressed to NGR, and 68 remained at pre-DM. Alterations in plasma metabolites in these groups were evaluated by untargeted ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Twenty three metabolites related to glycerophospholipid metabolism, oxidation and antioxidation were associated with the process from pre-DM to NGR, while twenty two metabolites related to amino acid metabolism, glycerophospholipid metabolism and mitochondrial β-oxidation played important roles in the progression to DM. Results from stepwise logistic regression analysis showed that five biomarkers (20-Hydroxy-leukotriene E4, Lysopc(20:4), 5-methoxytryptamine, Endomorphin-1, Lysopc(20:3)) were good prediction for the restoration to NGR, and five biomarkers (Iso-valeraldehyde, linoleic acid, Lysopc(18:1), 2-Pyrroloylglycine, Dityrosine) for the development of DM. The findings suggest that the combination of these potential metabolites may be used for the prognosis of pre-DM. Targeting the pathways that involved in these prognostic biomarkers would be beneficial for the regression to NGR and the early prevention of DM among pre-DM.

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Section: Discussionmentioning

confidence: 95%

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study

Zeng

Tong

et al. 2017

Sci Rep

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“…The cytotoxicity of the compounds, including the ligand precursor I , was tested at concentrations ranging between 0.1 and 80 μM in human embryonic kidney (HEK293) cells, prostate cancer (PC3) cells, cervical cancer (HeLa) cells, and glioblastoma (U251) cells for 48 h. Cytotoxicity was evaluated by the ability of cells to metabolize 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), as described elsewhere. 28 Accordingly, healthy human embryonic kidney cells, HEK293, were not sensitive to any of the compounds (cf. SI ).…”

Section: Resultsmentioning

confidence: 99%

N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

2018

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“…In addition, melatonin (50 mg/kg) was found to prevent the neuronal damage in the hippocampus in pregnant rats caused by 900 MHz electromagnetic fields (EMF), which might be associated with the use of mobile phones [308]. Furthermore, it has been suggested that if the N -acetyl group of melatonin was removed, its antioxidant and neuroprotective properties would be improved at the expense of toxic methamphetamine-like effects in several cell lines such as HT22 cells [309]. …”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin

Cited by 9 publications

References 52 publications

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study

N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

Dietary Sources and Bioactivities of Melatonin

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