2010
DOI: 10.1523/jneurosci.0825-10.2010
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Distinct Signals Conveyed by Pheromone Concentrations to the Mouse Vomeronasal Organ

Abstract: In mammalian species, detection of pheromone cues by the vomeronasal organ (VNO) at different concentrations can elicit distinct behavioral responses and endocrine changes. It is not well understood how concentration-dependent activation of the VNO impacts innate behaviors. In this study, we find that, when mice investigate the urogenital areas of a conspecific animal, the urinary pheromones can reach the VNO at a concentration of ϳ1% of that in urine. At this level, urinary pheromones elicit responses from a … Show more

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Cited by 54 publications
(58 citation statements)
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References 77 publications
(110 reference statements)
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“…1, A-C). As has previously been reported (Nodari et al 2008;Meeks et al 2010;He et al 2010;Arnson and Holy, unpublished observations), VSNs increased their firing rate in response to sulfated steroids with a monotonic dependence on concentration (Fig. 1D).…”
Section: Resultssupporting
confidence: 86%
See 1 more Smart Citation
“…1, A-C). As has previously been reported (Nodari et al 2008;Meeks et al 2010;He et al 2010;Arnson and Holy, unpublished observations), VSNs increased their firing rate in response to sulfated steroids with a monotonic dependence on concentration (Fig. 1D).…”
Section: Resultssupporting
confidence: 86%
“…The murine accessory olfactory system has been subject to a number of recent studies spanning both sensory neurons and downstream circuits (Meeks et al 2010;Ben-Shaul et al 2010;Hendrickson et al 2008;He et al 2008He et al , 2010Nodari et al 2008); however, the question of how information is being represented at the level of individual spikes has not been explored. In this study, we aimed to elucidate the physiological properties of VSNs that relate to how stimulus information is encoded and to explore the implications of these properties for decoding sensory responses.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, no manipulations of females' sex hormone status were carried out, and male VNO slices were not studied. More recently, He et al (2008He et al ( , 2010) studied the ability of male vs. female urinary odors to elevate intracellular calcium (an index of VNO receptor Fig. 3.…”
Section: Sex Differences In Vno-aob Responses To Pheromonesmentioning
confidence: 99%
“…We have developed transgenic mice that express G-CaMP2 in the olfactory sensory neurons, including the VSNs (15, 25). The sensitivity and the genetic nature of the probe greatly facilitate Ca 2+ imaging experiments by eliminating the dye loading process (4, 20).…”
Section: Introductionmentioning
confidence: 99%