Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement

Hermer-Vazquez, Linda; Hermer-Vazquez, Raymond; Moxon, Karen A.; Kuo, K.-H.; Viau, Victor; Ye, Zhan; Chapin, John K.

doi:10.1016/s0166-4328(03)00226-2

Cited by 43 publications

(53 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This window was defined the period from 50 ms before the videocoded Final Sniff time to 50 ms afterward, as determined by several factors: (1) prior results showing unit modulation during that task phase in that time window, (2) the correspondence between a sniff, in general, and the length of one theta cycle (Kepecs et al 2006), and (3) Monte Carlo simulations to find a window in which oscillations for the two trial types (GO and NO-GO) were maximally distinguished. This period also correlated well with our prior finding that unit firing rate modulation tended to occur within a ~100 ms window (Hermer-Vazquez et al 2004). We then systematically checked autocorrelograms at binwidths of 2, 5, 10, and 25 ms to determine the proportion of cells in each area for each rat that were oscillating above a 99% confidence level (above the background firing rate and assuming a Poisson distribution to calculate the window boundaries) in the beta, low gamma or high gamma band during the 100 ms Sniff-GO window versus the Sniff-NO-GO window.…”

Section: Discussionsupporting

confidence: 89%

“…In previous work, we showed that the firing rates of large percentages of multi-single units in the rat motor cortex and red nucleus were significantly modulated on at least five videocoded task phases (Fig. 1b;Hermer-Vazquez et al 2004). …”

Section: Introductionmentioning

confidence: 63%

“…Although we did not test whether the rats reliably detected an odor associated with the plastic-only pellets, several human subjects whom we tested were able to do so. We used this GO/NO-GO variant of the Whishaw reaching task because of the relatively simplified and highly regular kinematics displayed by rats across trials (Hermer-Vazquez et al 2004), which allowed us to perform both single-trial analyses and analyses on our neural data that averaged across trials. Once the task was well-learned, rats evaluated the pellet's odor in one to three respiratory cycles (~100-300 ms, with ~100 ms between the Final Sniff of the pellet and reaching on GO trials), and executed the reaching maneuver on GO-trials in <300 ms (see Fig.…”

Section: Behavioral Training and Testingmentioning

confidence: 99%

“…Also, the pPIR has been strongly implicated in complex odor task learning (Chabaud et al 1999;Haberly 2001;Mouly and Gervais 2002), that in rats is thought to be on a par with the executive-task abilities displayed by primates in the visual and auditory domains (Otto and Eichenbaum 1992;Dusek and Eichenbaum 1997;Dusek and Eichenbaum 1998;Schoenbaum and Setlow 2001). We recorded from the rat isocortical, caudal M1 and the subcortical, nuclear mRN because both areas (Kolb et al 2000) are involved in the processing underlying successful performance of the skilled reaching maneuver required for GO trials on our task (Whishaw and Gorny 1996;Hyland 1998;Hermer-Vazquez et al 2004). Also, the caudal M1 shows extensive plasticity as the skilled reaching task is learned (Kleim et al 2002).…”

Section: Electrode Implantationmentioning

confidence: 99%

See 3 more Smart Citations

Beta- and gamma-frequency coupling between olfactory and motor brain regions prior to skilled, olfactory-driven reaching

Hermer-Vazquez

Srinivasan

et al. 2007

Exp Brain Res

View full text Add to dashboard Cite

A major question in neuroscience concerns how widely separated brain regions coordinate their activity to produce unitary cognitive states or motor actions. To investigate this question, we employed multisite, multielectrode recording in rats to study how olfactory and motor circuits are coupled prior to the execution of an olfactory-driven, GO/NO-GO variant of a skilled, rapidly executed (~350-600 ms) reaching task. During task performance, we recorded multi-single units and local field potentials (LFPs) simultaneously from the rats' olfactory cortex (specifically, the posterior piriform cortex) and from cortical and subcortical motor sites (the caudal forepaw M1, and the magnocellular red nucleus, respectively). Analyses on multi-single units across areas revealed an increase in beta-frequency spiking (12-30 Hz) during a ~100 ms window surrounding the Final Sniff of the GO cue before lifting the arm (the "Sniff-GO window") that was seldom seen when animals sniffed the NO-GO cue. Also during the Sniff-GO window, LFPs displayed a striking increase in beta, low-gamma, and high-gamma energy (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) respectively), and oscillations in the high gamma band appeared to be coherent across the recorded sites. These results indicate that transient, multispectral coherence across cortical and subcortical brain sites is part of the coordination process prior to sensory-guided movement initiation.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 63%

Section: Behavioral Training and Testingmentioning

confidence: 99%

Section: Electrode Implantationmentioning

confidence: 99%

See 2 more Smart Citations

Beta- and gamma-frequency coupling between olfactory and motor brain regions prior to skilled, olfactory-driven reaching

Hermer-Vazquez

Srinivasan

et al. 2007

Exp Brain Res

View full text Add to dashboard Cite

show abstract

“…Vestibular signals participate in regulating hindlimb blood flow (20,22,41), and thus the infected neurons in the lateral vestibular nucleus likely are components of the neural pathway that mediates this response. The red nucleus is not typically considered to participate in autonomic regulation but instead plays a fundamental role in motor control in the rat (13,24). Red nucleus neurons could potentially contribute to altering limb blood flow in parallel with movement and thus may comprise elements in the neural circuit underlying central command (39).…”

Section: Discussionmentioning

confidence: 99%

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow

Lee

Lois²,

Troupe³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Lee T-K, Lois JH, Troupe JH, Wilson TD, Yates BJ. Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Am J Physiol Regul Integr Comp Physiol 292: R1532-R1541, 2007. First published December 7, 2007 doi:10.1152/ajpregu.00633.2006.-Despite considerable interest in the neural mechanisms that regulate muscle blood flow, the descending pathways that control sympathetic outflow to skeletal muscles are not adequately understood. The present study mapped these pathways through the transneuronal transport of two recombinant strains of pseudorabies virus (PRV) injected into the gastrocnemius muscles in the left and right hindlimbs of rats: PRV-152 and PRV-BaBlu. To prevent PRV from being transmitted to the brain stem via motor circuitry, a spinal transection was performed just below the L2 level. Infected neurons were observed bilaterally in all of the areas of the brain that have previously been shown to contribute to regulating sympathetic outflow: the medullary raphe nuclei, rostral ventrolateral medulla (RVLM), rostral ventromedial medulla, A5 adrenergic cell group region, locus coeruleus, nucleus subcoeruleus, and the paraventricular nucleus of the hypothalamus. The RVLM, the brain stem region typically considered to play the largest role in regulating muscle blood flow, contained neurons infected following the shortest postinoculation survival times. Approximately half of the infected RVLM neurons were immunopositive for tyrosine hydroxylase, indicating that they were catecholaminergic. Many (47%) of the RVLM neurons were dually infected by the recombinants of PRV injected into the left and right hindlimb, suggesting that the central nervous system has a limited capacity to independently regulate blood flow to left and right hindlimb muscles.

show abstract

Sleep as a window on the sensorimotor foundations of the developing hippocampus

Rio-Bermudez

Blumberg

2021

Hippocampus

View full text Add to dashboard Cite

The hippocampal formation plays established roles in learning, memory, and related cognitive functions. Recent findings also suggest that the hippocampus integrates sensory feedback from self‐generated movements to modulate ongoing motor responses in a changing environment. Such findings support the view of Bland and Oddie (Behavioural Brain Research, 2001, 127, 119–136) that the hippocampus is a site of sensorimotor integration. In further support of this view, we review neurophysiological evidence in developing rats that hippocampal function is built on a sensorimotor foundation and that this foundation is especially evident early in development. Moreover, at those ages when the hippocampus is first establishing functional connectivity with distant sensory and motor structures, that connectivity is preferentially expressed during periods of active (or REM) sleep. These findings reinforce the notion that sleep, as the predominant state of early infancy, provides a critical context for sensorimotor development, including development of the hippocampus and its associated network.

show abstract

Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement

Cited by 43 publications

References 63 publications

Beta- and gamma-frequency coupling between olfactory and motor brain regions prior to skilled, olfactory-driven reaching

Beta- and gamma-frequency coupling between olfactory and motor brain regions prior to skilled, olfactory-driven reaching

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow

Sleep as a window on the sensorimotor foundations of the developing hippocampus

Contact Info

Product

Resources

About