Distinction in EEG slow oscillations between chronic mild traumatic brain injury and PTSD

Franke, Lude; Walker, William C.; Hoke, Kathy; Wares, Joanna R.

doi:10.1016/j.ijpsycho.2016.05.010

Cited by 27 publications

(31 citation statements)

References 46 publications

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“…A recent MEG study indicates a spatial distinction in the change of spectral content following TBI, with parietal regions showing reduced δ power while other brain areas show increases 68 . Another study on chronic blast TBI patients also show some brain regions, including prefrontal and right temporal cortices, have more prominent δ power increase 55 . Considering that we performed ECoG recording from the same location in both contralateral and ipsilateral experiments, we think the difference in post-injury δ power change may be correlated with primary injury site.…”

Section: Discussionmentioning

confidence: 90%

Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences

Solarana

Rafi

et al. 2019

Sci Rep

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Exposure of the brain to high-intensity stress waves creates the potential for long-term functional deficits not related to thermal or cavitational damage. Possible sources of such exposure include overpressure from blast explosions or high-intensity focused ultrasound (HIFU). While current ultrasound clinical protocols do not normally produce long-term neurological deficits, the rapid expansion of potential therapeutic applications and ultrasound pulse-train protocols highlights the importance of establishing a safety envelope beyond which therapeutic ultrasound can cause neurological deficits not detectable by standard histological assessment for thermal and cavitational damage. In this study, we assessed the neuroinflammatory response, behavioral effects, and brain micro-electrocorticographic (µECoG) signals in mice following exposure to a train of transcranial pulses above normal clinical parameters. We found that the HIFU exposure induced a mild regional neuroinflammation not localized to the primary focal site, and impaired locomotor and exploratory behavior for up to 1 month post-exposure. In addition, low frequency (δ) and high frequency (β, γ) oscillations recorded by ECoG were altered at acute and chronic time points following HIFU application. ECoG signal changes on the hemisphere ipsilateral to HIFU exposure are of greater magnitude than the contralateral hemisphere, and persist for up to three months. These results are useful for describing the upper limit of transcranial ultrasound protocols, and the neurological sequelae of injury induced by high-intensity stress waves.

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Section: Discussionmentioning

confidence: 90%

Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences

Solarana

Rafi

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Franke and colleagues have shown that mild TBI induces slowing of EEG oscillations. 21 This slowing may account for the earlier onset of mild cognitive impairment in this population. 22 Furthermore, patients frequently present with deficits in executive function.…”

Section: Chronic Changesmentioning

confidence: 94%

Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury

Lucke‐Wold

Logsdon

Nguyen

et al. 2016

Nutritional Neuroscience

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Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic options remain limited. Traditional pharmaceutical interventions have failed to transition to the clinic for the treatment of mild TBI. As such, many pre-clinical studies are now implementing non-pharmaceutical therapies for TBI. These studies have demonstrated promise, particularly those that modulate secondary injury cascades activated after injury. Because no TBI therapy has been discovered for mild injury, researchers now look to pharmaceutical supplementation in an attempt to foster success in human clinical trials. Non-traditional therapies, such as acupuncture and even music therapy are being considered to combat the neuropsychiatric symptoms of TBI. In this review, we highlight alternative approaches that have been studied in clinical and pre-clinical studies of TBI, and other related forms of neural injury. The purpose of this review is to stimulate further investigation into novel and innovative approaches that can be used to treat the mechanisms and symptoms of mild TBI.

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“…The authors suggested that such abnormalities could be directly related to the control of thought processes in Veterans with mTBI and PTSD. Franke and colleagues examined the spectral power of the EEG signal during rest (a task-less paradigm similar to what is done in many fMRI connectivity studies) in Veterans with a range of mTBI and PTSD exposure and severity [70]. Individuals with PTSD had reduced low frequency power localized to right temporal and parietal cortex.…”

Section: Electroencephalography (Eeg) and Event Related Potentials (Erp)mentioning

confidence: 99%

Neuroimaging of deployment-associated traumatic brain injury (TBI) with a focus on mild TBI (mTBI) since 2009

et al. 2017

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Distinction in EEG slow oscillations between chronic mild traumatic brain injury and PTSD

Cited by 27 publications

References 46 publications

Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences

Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences

Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury

Neuroimaging of deployment-associated traumatic brain injury (TBI) with a focus on mild TBI (mTBI) since 2009

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