Distinctive Effect of Donepezil Treatment on P300 and N200 Subcomponents of Auditory Event-Related Evoked Potentials in Alzheimer Disease Patients

Vaitkevičius, Arūnas; Kaubrys, Gintaras; Audronyte, Egle

doi:10.12659/msm.894940

Cited by 17 publications

(14 citation statements)

References 21 publications

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“…Depression, age, education level, and gender are all demographic and clinical factors associated with specific features of cognitive disorders and response to treatment [ 36 ]. Vice versa, symptomatic treatment for AD itself may not only produce the modified phenotype of cognitive disorders, but also can cause an atypical pattern of electrophysiological responses in Alzheimer’s disease [ 37 ]. Regardless of various kinds of obstacles, studies of executive dysfunction in AD are worth the effort, because earlier detection of dysexecutive syndrome in AD can improve the potential benefit of treatment, reduce the burden on caregivers and residential care services, and provide better quality of life for AD patients [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results

Kuzmickienė

Kaubrys

2016

Med Sci Monit

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BackgroundThe primary manifestation of Alzheimer’s disease (AD) is decline in memory. Dysexecutive symptoms have tremendous impact on functional activities and quality of life. Data regarding frontal-executive dysfunction in mild AD are controversial. The aim of this study was to assess the presence and specific features of executive dysfunction in mild AD based on Cambridge Neuropsychological Test Automated Battery (CANTAB) results.Material/MethodsFifty newly diagnosed, treatment-naïve, mild, late-onset AD patients (MMSE ≥20, AD group) and 25 control subjects (CG group) were recruited in this prospective, cross-sectional study. The CANTAB tests CRT, SOC, PAL, SWM were used for in-depth cognitive assessment. Comparisons were performed using the t test or Mann--Whitney U test, as appropriate. Correlations were evaluated by Pearson r or Spearman R. Statistical significance was set at p<0.05.ResultsAD and CG groups did not differ according to age, education, gender, or depression. Few differences were found between groups in the SOC test for performance measures: Mean moves (minimum 3 moves): AD (Rank Sum=2227), CG (Rank Sum=623), p<0.001. However, all SOC test time measures differed significantly between groups: SOC Mean subsequent thinking time (4 moves): AD (Rank Sum=2406), CG (Rank Sum=444), p<0.001. Correlations were weak between executive function (SOC) and episodic/working memory (PAL, SWM) (R=0.01–0.38) or attention/psychomotor speed (CRT) (R=0.02–0.37).ConclusionsFrontal-executive functions are impaired in mild AD patients. Executive dysfunction is highly prominent in time measures, but minimal in performance measures. Executive disorders do not correlate with a decline in episodic and working memory or psychomotor speed in mild AD.

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Section: Discussionmentioning

confidence: 99%

Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results

Kuzmickienė

Kaubrys

2016

Med Sci Monit

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“…Neuroimaging indicators may be able to significantly strengthen the predictive value of the cognitive and demographic predictors, as has been shown in the case of quantitative MRI with the measurement of diffusion and perfusion alterations [ 51 ]. In this study we did not use electrophysiological indicators of AD progression, such as P300 and N200 Event-related Evoked Potentials (ERPs), which are the indicators of neurobiological nature and may provide additional and independent information regarding AD progression in comparison with the cognitive markers, which are behavioral indicators by their very nature [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

Kuzmickienė¹,

Kaubrys

2015

Med Sci Monit

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BackgroundAbility to predict the efficacy of treatment in Alzheimer disease (AD) may be very useful in clinical practice. Cognitive predictors should be investigated alongside with the demographic, genetic, and other predictors of treatment efficacy. The aim of this study was to establish whether the baseline measures of CANTAB tests and their changes due to the first donepezil dose are able to predict the efficacy of treatment after 4 months of therapy. We also compared the predictive value of cognitive, clinical, and demographic predictors of treatment efficacy in AD.Material/MethodsSeventy-two AD patients (62 treatment-naïve and 10 donepezil-treated) and 30 controls were enrolled in this prospective, randomized, rater-blinded, follow-up study. Treatment-naïve AD patients were randomized to 2 groups to take the first donepezil dose after the first or second CANTAB testing, separated by 4 hours. Follow-up Test 3 was performed 4 months after the initial assessment.ResultsThe groups were similar in age, education, gender, Hachinski index, and depression. General Regression Models (GRM) have shown that cognitive changes after the first dose of donepezil in PAL (t-values for regression coefficients from 3.43 to 6.44), PRMd (t=4.33), SWM (t=5.85) test scores, and baseline results of PAL (t=2.57–2.86), PRM (t=3.08), and CRT (t=3.42) tests were significant predictors of long-term donepezil efficacy in AD (p<0.05).ConclusionsThe cognitive changes produced by the first donepezil dose in CANTAB PAL, PRM, and SWM test measures are able to predict the long-term efficacy of donepezil in AD. Baseline PAL, PRM, and CRT test results were significant predictors.

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“…Second, the amplitude of P300s that passed criterion was smaller in schizophrenics, and, third, the single-trial latency was greater in schizophrenics. Demonstrating further potential for clinical use as a correlate to cognitive function, P300 has been shown to strengthen in response to various treatments (Kouri et al, 1996; Werber et al, 2003; Tilki et al, 2004; Chang et al, 2014; Khedr et al, 2014; Vaitkevičius et al, 2015). However, the mechanisms underlying the variations in within-subject average P300 remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Single-Trial Mechanisms Underlying Changes in Averaged P300 ERP Amplitude and Latency in Military Service Members After Combat Deployment

Trongnetrpunya

Rapp

Wang

et al. 2019

Front. Hum. Neurosci.

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Attenuation in P300 amplitude has been characterized in a wide range of neurological and psychiatric disorders such as dementia, schizophrenia, and posttraumatic stress disorder (PTSD). However, it is unclear whether the attenuation observed in the averaged event-related potential (ERP) is due to the reduction of neural resources available for cognitive processing, the decreased consistency of cognitive resource allocation, or the increased instability of cognitive processing speed. In this study, we investigated this problem by estimating single-trial P300 amplitude and latency using a modified Woody filter and examined the relation between amplitudes and latencies from the single-trial level to the averaged ERP level. ERPs were recorded from 30 military service members returning from combat deployment at two time points separated by 6 or 12 months. A conventional visual oddball task was used to elicit P300. We observed that the extent of changes in the within-subject average P300 amplitude over time was significantly correlated with the amount of change in three single-trial measures: (1) the latency variance of the single-trial P300 (r = −0.440, p = 0.0102); (2) the percentage of P300-absent trials (r = −0.488, p = 0.005); and (3) the consistent variation of the single-trial amplitude (r = 0.571, p = 0.0022). These findings suggest that there are multiple underlying mechanisms on the single-trial level that contribute to the changes in amplitudes seen at the averaged ERP level. The changes between the first and second assessments were quantified with the intraclass correlation coefficient, the standard error of measurement and the minimal detectable difference. The unique population, the small sample size and the large fraction of participants lost to follow up precludes generalizations of these measures of change to other populations.

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Distinctive Effect of Donepezil Treatment on P300 and N200 Subcomponents of Auditory Event-Related Evoked Potentials in Alzheimer Disease Patients

Cited by 17 publications

References 21 publications

Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results

Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results

Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

Single-Trial Mechanisms Underlying Changes in Averaged P300 ERP Amplitude and Latency in Military Service Members After Combat Deployment

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