Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease

Aukema, Harold M.; Gauthier, Joy; Roy, M; Jia, Yong; Li, Huan; Aluko, Rotimi E.

doi:10.1002/mnfr.201000558

Cited by 27 publications

(12 citation statements)

References 59 publications

(58 reference statements)

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“…In conclusion, different dietary habits are known to have an impact on the host wellbeing by influencing, among others, glycaemic response [44], modulation of atherogenic pathways [45], risk for metabolic syndrome [46], and renal disease progression [47]. Moreover, fiber consumption is apparently inversely associated with cardiovascular disease and cancer mortality [48].…”

Section: Discussionmentioning

confidence: 99%

High‐fiber and high‐protein diets shape different gut microbial communities, which ecologically behave similarly under stress conditions, as shown in a gastrointestinal simulator

Marzorati

Vílchez-Vargas

Bussche

et al. 2016

Molecular Nutrition Food Res

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The aim of this work was to investigate the relationship between the structure of gut microbial communities fed with different diets (i.e. high-protein-HP- versus high-fiber-HF-diet) and their functional stability when challenged with mild and acute doses of a mix of amoxicillin, ciprofloxacin, and tetracycline. We made use of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)-a continuous model of the gastrointestinal tract-coupled with 16S-targeted Illumina and metabolomics (i.e. UHPLC-HRMS) analyses. Independently of the diet, the sudden exposure to an acute stress led to a modification of the microbial community structure, selecting for species belonging to Bacillus spp.; Clostridium cluster XIVa; Enterococci; Bacteroides; and Enterobacteriaceae. The antibiotic treatment led to a decrease in the number of operational taxonomic units (at least -10%). Cluster analysis of untargeted metabolic data showed that the antibiotic treatment affected the microbial activity. The impact on metabolites production was lower when the community was preexposed to mild doses of the antibiotic mix. This effect was stronger in the proximal colon for the HF diet and in the distal colon for the HP diet. Different diets shaped different gut microbial communities, which ecologically behaved similarly under stress conditions.

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Section: Discussionmentioning

confidence: 99%

High‐fiber and high‐protein diets shape different gut microbial communities, which ecologically behave similarly under stress conditions, as shown in a gastrointestinal simulator

Marzorati

Vílchez-Vargas

Bussche

et al. 2016

Molecular Nutrition Food Res

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“…FPI (from Section 3.2.1), 2.5% FPH and 3.0% FPH samples obtained by the digestion of FPI with 2.5% and 3.0% thermoase GL-30, respectively, the membrane fractions (<1, 1–3, 3–5 and 5–10 kDa in size) from the ultrafiltration of each of the two FPH samples, as well as captopril were each dissolved in phosphate-buffered saline (PBS), pH 7.2. The samples (each at 200 mg/kg BW), PBS (used as negative control), and captopril (10 mg/kg BW; used as positive control) were administered to the SHR by oral gavage followed by measurement of systolic blood pressure (SBP) by tail-cuff plethysmography (Mouse Rat Tail Cuff Blood Pressure System, IITC Life Science, Woodland Hills, CA, USA) at 2, 4, 6, 8 and 24 h in rats mildly anesthetized for 4 min with 4% isoflurane [9,32]. The gas flow chamber, maintained at 37 °C, was designed to include positive pressure ventilation in order to sustain independent ventilatory function and attenuate isoflurane-induced depression of spontaneous ventilation in the animals.…”

Section: Methodsmentioning

confidence: 99%

Thermoase-Derived Flaxseed Protein Hydrolysates and Membrane Ultrafiltration Peptide Fractions Have Systolic Blood Pressure-Lowering Effects in Spontaneously Hypertensive Rats

Nwachukwu

Girgih

Malomo

et al. 2014

IJMS

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Thermoase-digested flaxseed protein hydrolysate (FPH) samples and ultrafiltration membrane-separated peptide fractions were initially evaluated for in vitro inhibition of angiotensin I-converting enzyme (ACE) and renin activities. The two most active FPH samples and their corresponding peptide fractions were subsequently tested for in vivo antihypertensive activity in spontaneously hypertensive rats (SHR). The FPH produced with 3% thermoase digestion showed the highest ACE- and renin-inhibitory activities. Whereas membrane ultrafiltration resulted in significant (p < 0.05) increases in ACE inhibition by the <1 and 1–3 kDa peptides, only a marginal improvement in renin-inhibitory activity was observed for virtually all the samples after membrane ultrafiltration. The FPH samples and membrane fractions were also effective in lowering systolic blood pressure (SBP) in SHR with the largest effect occurring after oral administration (200 mg/kg body weight) of the 1–3 kDa peptide fraction of the 2.5% FPH and the 3–5 kDa fraction of the 3% FPH. Such potent SBP-lowering capacity indicates the potential of flaxseed protein-derived bioactive peptides as ingredients for the formulation of antihypertensive functional foods and nutraceuticals.

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“…Following oral administration by syringe gavage, the effects of samples on SBP were compared to that of captopril. SBP was measured by tail-cuff plethysmography at 2, 4, 6, 8 and 24 h (post oral administration of samples) in mildly anesthetized rats according to the method of Aukema et al [19]. In order to mitigate the SBP depression effect of isofluorane, the gas flow was optimized such that rats became conscious usually within 3-4 min after removal from the chamber, which provided enough time to perform the blood pressure measurement.…”

Section: Shrs and Measurement Of Systolic Blood Pressurementioning

confidence: 99%

Kinetics of Enzyme Inhibition and Antihypertensive Effects of Hemp Seed (Cannabis sativa L.) Protein Hydrolysates

Girgih

Udenigwe

et al. 2011

J Americ Oil Chem Soc

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147

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The aim of this study was to determine the antihypertensive effects of enzymatic hemp seed protein hydrolysate (HPH) and its peptide fractions. Hemp seed protein isolate was digested by the sequential action of pepsin and pancreatin to mimic gastrointestinal digestion in human beings. The resultant HPH was separated by membrane ultrafiltration into peptide fractions with different sizes (\1 and 1-3 kDa). The HPH led to significantly higher (P \ 0.05) in vitro inhibition of the activities of angiotensin I-converting enzyme (ACE) and renin, the two main enzymes involved in abnormal blood pressure elevation (hypertension). Kinetic studies showed that HPH and peptide fractions inhibited renin and ACE activities in a mixed-type pattern, indicating binding to areas other than the active site. Oral administration of HPH (200 mg/kg body weight) to spontaneously hypertensive rats led to significant reductions (P \ 0.05) in systolic blood pressure (SBP) that reached a maximum of -30 mmHg after 8 h. In contrast, the hypotensive effects of peptide fractions (\1 and 1-3 kDa) had a maximum value of about -15 mmHg after 6-8 h post oral administration. The results suggest a synergistic antihypertensive effect of the peptides present within HPH; this effect was reduced significantly (P \ 0.05) upon separation into peptide fractions.

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Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease

Abstract: Not all plant proteins are equally protective in experimental kidney disease and associated cardiac hypertrophy.

Cited by 27 publications

References 59 publications

High‐fiber and high‐protein diets shape different gut microbial communities, which ecologically behave similarly under stress conditions, as shown in a gastrointestinal simulator

High‐fiber and high‐protein diets shape different gut microbial communities, which ecologically behave similarly under stress conditions, as shown in a gastrointestinal simulator

Thermoase-Derived Flaxseed Protein Hydrolysates and Membrane Ultrafiltration Peptide Fractions Have Systolic Blood Pressure-Lowering Effects in Spontaneously Hypertensive Rats

Kinetics of Enzyme Inhibition and Antihypertensive Effects of Hemp Seed (Cannabis sativa L.) Protein Hydrolysates

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