Distinctive plume formation in atmospheric Ar and He plasmas in microwave frequency band and suitability for biomedical applications

Lee, H. Wk.; Kang, Seong-Hoon; Won, I. H.; Kim, H. Y.; Kwon, Hyeokjae; Sim, Jae‐Yoon; Lee, J. K.

doi:10.1063/1.4841295

Cited by 41 publications

(32 citation statements)

References 51 publications

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“…Thence, the bulk plasma density n bulk can be calculated 8:3 Â 10 20 m -3 approximately. It should be mentioned that although this density value is consistent with previous studies reported from the similar lowerpower argon microwave plasma jets driven by continues microwave power in ambient air, [3][4][5][6][7][8][9][10][11][12][13][14][15][16]32 the actual plasma density of the pulsed plasma jet is lower than this value, due to the average power absorbed by the electrons lower largely in pulsed discharge with the same peak power amplitude.…”

Section: Experimental Summarysupporting

confidence: 81%

“…The plasma impedance can be estimated by fitting the calculated reflection coefficient to about 800 X-j350 X. A detailed procedure based on transmission line theory is described in the literatures and the bulk plasma density can be estimated from the following equation: 3,32 n bulk ¼ L bulk m e en R p q 2 A bulk ;…”

Section: Experimental Summarymentioning

confidence: 99%

“…1,2 One type of them, named low-power microwave-driven atmospheric plasma jet, is generated based on microwave resonant effect, which have several advantages over low-frequency plasmas, such as higher density of electron and reactive species, lower plasma plume temperature, lower applied power, and longer electrode lifetime. [3][4][5][6][7] Especially for several applications, such as medical instrument sterilization, metal surface nitriding, and high-velocity fuel ignition and combustion, atmospheric microwave plasma devices have shown its potential advantages in industrial applications. [8][9][10][11] There are four types of low-power microwave resonators: coaxial transmission line resonators (CTLR), 3 microstrip line resonators, 4 surfatron launchers, 12 and surface-wave plasma jets, [13][14][15] which are with different characteristics and thereafter are constructed for satisfying different application demands.…”

mentioning

confidence: 99%

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Self-consistent fluid modeling and simulation on a pulsed microwave atmospheric-pressure argon plasma jet

Chen

Yin

Ming-gong

et al. 2014

Journal of Applied Physics

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In present study, a pulsed lower-power microwave-driven atmospheric-pressure argon plasma jet has been introduced with the type of coaxial transmission line resonator. The plasma jet plume is with room air temperature, even can be directly touched by human body without any hot harm. In order to study ionization process of the proposed plasma jet, a self-consistent hybrid fluid model is constructed in which Maxwell's equations are solved numerically by finite-difference time-domain method and a fluid model is used to study the characteristics of argon plasma evolution. With a Guass type input power function, the spatio-temporal distributions of the electron density, the electron temperature, the electric field, and the absorbed power density have been simulated, respectively. The simulation results suggest that the peak values of the electron temperature and the electric field are synchronous with the input pulsed microwave power but the maximum quantities of the electron density and the absorbed power density are lagged to the microwave power excitation. In addition, the pulsed plasma jet excited by the local enhanced electric field of surface plasmon polaritons should be the discharge mechanism of the proposed plasma jet.

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Section: Experimental Summarysupporting

confidence: 81%

Section: Experimental Summarymentioning

confidence: 99%

mentioning

confidence: 99%

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Self-consistent fluid modeling and simulation on a pulsed microwave atmospheric-pressure argon plasma jet

Chen

Yin

Ming-gong

et al. 2014

Journal of Applied Physics

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“…Figure (a) shows the side views of the Ar microwave plasma plume with a variation of air mixture from 0 to 5%. The Ar discharges form contracted plasma plumes with a stationary filament located axially at the center of the plume, with glowing regions nearby . Ar/Air discharges in CTLRs exhibit a unique standing striation pattern.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Effects of Ar/Air Microwave Plasma on Wound Healing

Kim

Kang

Park

et al. 2015

Plasma Processes & Polymers

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1Using Ar/Air mixture microwave plasma, we investigated the effects of air and gas temperature on the generation of electrons, ozone (O 3 ), and nitric oxide (NO) through experiments and chemical kinetics simulation. The global model (GM) chemical kinetics simulation was used to validate and complement experimental observations. As the air percentages in Ar plasma increase, electrons are mainly generated by reactive oxygen species (ROS), but electron densities decrease. This is why plasma jet length becomes shorter with the mixture of air to Ar plasma at the same power. The profile of O 3 densities has a maximum point because these are affected by oxygen (O 2 ) molecules and gas temperature. O 3 densities increase because these are generated via recombination of atomic oxygen (O) and O 2 radicals as the air percentages increase. As the gas temperature increases, O 3 densities decrease and O 3 radicals are mainly destroyed by ROS such as O 2 À , excited O 2 , and O, although air percentages increase. NO radicals increase continually with the addition of air mixture and increase in gas temperature. With respect to biomedical applications, in the case of Ar/Air plasma treatment, it takes just 2 d, which has reduced the wound area to 30% because of faster scab formation over the wound and mRNA activation. Abundant NO radicals with ROS in Ar/aAir plasma strongly enhance IL-6 and TGF-b1, which facilitate collagen remodeling and wound recovery effectively.

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“…Only little microwave power can leak from the microwave plasma source. A low E-field has been found to exist near the open end, and the E-field intensity reduces exponentially as the distance increases [ 27 ]. This indicates that the effect of microwave leakage on patients is negligible.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of the killing effect of low-temperature plasma on Streptococcus mutans by combined treatment with gold nanoparticles

et al. 2014

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BackgroundRecently, non-thermal atmospheric pressure plasma sources have been used for biomedical applications such as sterilization, cancer treatment, blood coagulation, and wound healing. Gold nanoparticles (gNPs) have unique optical properties and are useful for biomedical applications. Although low-temperature plasma has been shown to be effective in killing oral bacteria on agar plates, its bactericidal effect is negligible on the tooth surface. Therefore, we used 30-nm gNPs to enhance the killing effect of low-temperature plasma on human teeth.ResultsWe tested the sterilizing effect of low-temperature plasma on Streptococcus mutans (S. mutans) strains. The survival rate was assessed by bacterial viability stains and colony-forming unit counts. Low-temperature plasma treatment alone was effective in killing S. mutans on slide glasses, as shown by the 5-log decrease in viability. However, plasma treatment of bacteria spotted onto tooth surface exhibited a 3-log reduction in viability. After gNPs were added to S. mutans, plasma treatment caused a 5-log reduction in viability, while gNPs alone did not show any bactericidal effect. The morphological changes in S. mutans caused by plasma treatment were examined by transmission electron microscopy, which showed that plasma treatment only perforated the cell walls, while the combination treatment with plasma and gold nanoparticles caused significant cell rupture, causing loss of intracellular components from many cells.ConclusionsThis study demonstrates that low-temperature plasma treatment is effective in killing S. mutans and that its killing effect is further enhanced when used in combination with gNPs.

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Distinctive plume formation in atmospheric Ar and He plasmas in microwave frequency band and suitability for biomedical applications

Cited by 41 publications

References 51 publications

Self-consistent fluid modeling and simulation on a pulsed microwave atmospheric-pressure argon plasma jet

Self-consistent fluid modeling and simulation on a pulsed microwave atmospheric-pressure argon plasma jet

Characterization and Effects of Ar/Air Microwave Plasma on Wound Healing

Enhancement of the killing effect of low-temperature plasma on Streptococcus mutans by combined treatment with gold nanoparticles

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