Distinguishing C1q nephropathy from lupus nephritis

Sharman, Andrew; Furness, Peter; Feehally, John

doi:10.1093/ndt/gfh139

Cited by 58 publications

(58 citation statements)

References 10 publications

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“…In 30.6%, a "full house" pattern, which is often observed in lupus nephritis, 11 was demonstrated significantly more frequently in patients with proliferative glomerulonephritis; however, none of our patients showed any feature of SLE at the time of biopsy or after a mean 5.4-yr follow-up, including six with endothelial tubuloreticular inclusions and two with extraglomerular small vessel vasculitis. Similarly to our results, Sharman et al 12 described nine patients who had C1q nephropathy and for whom a diagnosis of "seronegative lupus nephritis" had initially been considered. None of these patients developed SLE during a mean follow-up of 5.1 yr.…”

Section: Discussionsupporting

confidence: 89%

“…1,3,8,12 In our study, deposits were demonstrated in 90.6% of cases. We believe that occasional segmental distribution of immune deposits in C1q nephropathy may be the reason that they are not sampled for electron microscopy in some biopsies.…”

Section: Discussionsupporting

confidence: 57%

“…Proliferative glomerulonephritis has been found with various frequencies in the reported C1q nephropathy series, as well as in a few case reports. 1,4,7,8,12,15,16 This form of C1q nephropathy has characteristic features of immune complex-mediated glomerulonephritis and may share similarities with IgA nephropathy. 8 A patient can in fact fulfill the diagnostic criteria for both conditions.…”

Section: Discussionmentioning

confidence: 99%

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Pathology, Clinical Presentations, and Outcomes of C1q Nephropathy

Vizjak

Ferluga

Rožič

et al. 2008

Journal of the American Society of Nephrology

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C1q nephropathy is an uncommon glomerular disease with characteristic features on immunofluorescence microscopy. In this report, clinicopathologic correlations and outcomes are presented for 72 patients with C1q nephropathy. The study comprised 82 kidney biopsies from 28 children and 54 adults with male preponderance (68%). Immunofluorescence microscopy showed dominant or co-dominant staining for C1q in the mesangium and occasional glomerular capillary walls. Electron-dense deposits were observed in 48 of 53 cases. Light microscopy revealed no lesions

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pathology, Clinical Presentations, and Outcomes of C1q Nephropathy

Vizjak

Ferluga

Rožič

et al. 2008

Journal of the American Society of Nephrology

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“…C1q nephropathy is an uncommon pathological entity accounting for 0.4- 2.0% of all consecutive native kidney biopsies [5][6][7]. The distinguishing characteristics of C1q nephropathy are robust staining of C1q on immunofluorescence, absence of endothelial cell TRIs [8] and anti C1q antibodies [9]. Even though our index patient had C1q 2+ on IF, the presence of TRIs with sub endothelial deposits excludes C1q nephropathy.…”

Section: Discussionmentioning

confidence: 96%

Seronegative lupus membranous nephropathy

Kiran¹

2016

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.com Seronegative lupus membranous nephropathyMandya Chikkalingaiah Kiran ABSTRACT Introduction: Lupus nephritis represents the greater part of systemic lupus erythematosus (SLE) involvement. Antinuclear antibody (ANA) is positive in more than 95% of SLE population. Literature depicts the prevalence of ANA negativity around 1-5% and more prevalent in young females as seropositive lupus. Existence of full-house nephropathy is generally associated with lupus nephritis. Case Report: We present a case of full-house nephropathy in a 24-year-old female patient with negative serology for SLE presenting with nephrotic syndrome. Renal biopsy revealed tubuloreticular inclusions (TRIs) in endothelial cells differentiating itself from rarer C1q nephropathy. Patient had partial response with conventional immunotherapy with mycophenolate mofetil (MMF) and prednisone. Conclusion:The role of B cell depleting therapy in seronegative lupus; this population needs to be explored in future.

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“…Jones and Magil and Sharman et al reported such non-systemic mesangiopathic glomerulonephritis without progression to overt lupus nephritis [1,18]. Therefore, the term seronegative lupus nephritis is not useful.…”

Section: Discussionmentioning

confidence: 99%

The Heterogeneity and Controversy of C1q Nephropathy: A Report of Two Cases and Review of the Literature

Husain

2014

World J Nephrol Urol

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C1q is an uncommon, controversial and under-recognized entity. There is disagreement regarding whether it is an established disease or just part of the spectrum of minimal change disease and focal segmental glomerulosclerosis. C1q nephropathy is diagnosed solely by kidney biopsy. We report two cases of C1q nephropathy, one in a 39-year-old man and the other in an 8-year-old boy. Our two cases highlight the variable nature of this disease. In this article, we present our cases, review the criteria for diagnosis and highlight the heterogeneous nature of this disease in terms of clinical presentation, renal biopsy and variable outcomes. We also discuss the postulated etiopathogenetic mechanisms and note the reported associations.

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Distinguishing C1q nephropathy from lupus nephritis

Cited by 58 publications

References 10 publications

Pathology, Clinical Presentations, and Outcomes of C1q Nephropathy

Pathology, Clinical Presentations, and Outcomes of C1q Nephropathy

Seronegative lupus membranous nephropathy

The Heterogeneity and Controversy of C1q Nephropathy: A Report of Two Cases and Review of the Literature

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