Distinguishing Constitutional Delay of Growth and Puberty from Isolated Hypogonadotropic Hypogonadism: Critical Appraisal of Available Diagnostic Tests

Harrington, Jennifer; Palmert, Mark R.

doi:10.1210/jc.2012-1598

Cited by 195 publications

(126 citation statements)

References 80 publications

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“…At E15 or E16, the number of ZBTB20-positive cells increased significantly. As this is also the differentiation time of GH and PRL, it can be deduced that ZBTB20 expression occurred before the differentiation of these two hormones, suggesting the potential participation of ZBTB20 in this process, and in maintaining normal morphology and function of pituitary (El Chehadeh et al, 2010;Di Iorgi et al, 2012b;Harrington and Palmert, 2012).…”

Section: Discussionmentioning

confidence: 91%

Effect of transcription factor ZBTB20 on mouse pituitary development

Dong

Chen

2015

Genet. Mol. Res.

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ABSTRACT. Pituitary, a critical component in the neuroendocrine system, plays an indispensable role in the regulation of body growth. The transcriptional factor ZBTB20 is widely expressed in brain tissues and participates in hippocampal development; however, the detailed molecular mechanism remains unknown. Therefore, the aim of this study was to investigate the effect of ZBTB20 on mouse pituitary development and related mechanisms in ZBTB20 gene knockout mice. The expressional profiles of ZBTB20 in various neuroendocrinal cells during the different developmental stages (from E10 to P0) were described by immunofluorescence staining. A ZBTB20 gene knockout mouse model was then generated. Real-time polymerase chain reaction and western blotting assays were used to detect the levels of five hormones: growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroidstimulating hormone (TSH). ZBTB20 protein expression was identified from E14 until birth. A majority of the pituitary endocrinal cells were ZBTB20-positive. In ZBTB20 knockout mice, the level of GH decreased by half and PRL expression was eliminated. No significant change was observed in the other three hormones (LH, FSH, and TSH). ZBTB20, an important transcriptional factor in pituitary development, is mainly responsible for the 17623 ZBTB20 regulates pituitary development ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17622-17629 (2015) terminal differentiation of prolactin-secreting cells, thereby regulating the secretion of the pituitary hormones.

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Section: Discussionmentioning

confidence: 91%

Effect of transcription factor ZBTB20 on mouse pituitary development

Dong

Chen

2015

Genet. Mol. Res.

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“…Identifying undescended testis is a clinical clue that the child has IHH. Establishing the diagnosis requires correlation of the history and physical with laboratory tests [9,10]. When IHH is suspected, evaluation includes demonstrating low concentrations of sex steroid hormones, inappropriately low or normal LH and FSH levels, with otherwise normal pituitary function aside from GnRH-related hormonal disturbance.…”

Section: Discussionmentioning

confidence: 99%

Congenital Idiopathic Hypogonadotropic Hypogonadism: A Case Report

Sumko¹,

Stoutt

Weis³

et al. 2014

J Clin Case Rep

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A 27 year old white male presented to a family medicine clinic with complaint of a changing skin lesion that was a melanoma in situ. As a result, he had a full-skin exam and was found to have a microphallus, undescended testes, and minimal pubic hair distribution. He had a normal sense of smell. Laboratory evaluation showed total testosterone to be 26 ng/dL (250-1100 normal), LH 0.4 mIU/mL (1.5-9.3 normal), and FSH 1.6 mIU/mL (1.6-8.0 normal). Prolactin, PTH, and calcium were within normal limits, as well as his CBC and BMP. MRI of the brain showed no lesions of the hypothalamus or pituitary gland. An abdominal CT and DEXA scan revealed undescended testes and osteopenia, respectively. He was diagnosed as IHH. The patient was provided with supplementary vitamin D, calcium and referrals to endocrinology and urology for orchiopexy. This patient was followed at my clinic regularly. By the time that this manuscript was written, urologist evaluated the patient and orchiopexy was scheduled.

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“…The use of aromatase inhibitors and oxandrolone, a weak anabolic steroid has been shown to be effective in children with CGDP. Results are encouraging in terms of effective increase in height [14,15]. The short courses of low-dose testosterone therapy also appear to be efficacious and safe for treatment of appropriately selected individual's boys with constitutional delay of growth and puberty [16,17].…”

Section: Introductionmentioning

confidence: 94%

The Effect of Clonidine Therapy on Height and Growth Velocity in Constitutional Growth and Puberty Delay

Razavi

Rabbani

Bazmamoun

2016

Zahedan J Res Med Sci

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Background: Constitutional delay of growth and puberty (CDGP) is the most common cause of short stature. This variant of normal growth can be associated with psychological stress in some affected individuals. Objectives: We aimed to assess the effects of clonidine on short-term growth rate in children and adolescents with constitutional growth delay. Patients and Methods: In this prospective, randomized clinical trial study, 48 prepubertal constitutionally short boys (6 -12 years

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Distinguishing Constitutional Delay of Growth and Puberty from Isolated Hypogonadotropic Hypogonadism: Critical Appraisal of Available Diagnostic Tests

Cited by 195 publications

References 80 publications

Effect of transcription factor ZBTB20 on mouse pituitary development

Effect of transcription factor ZBTB20 on mouse pituitary development

Congenital Idiopathic Hypogonadotropic Hypogonadism: A Case Report

The Effect of Clonidine Therapy on Height and Growth Velocity in Constitutional Growth and Puberty Delay

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