Distribuição Geográfica de DTUs do Trypanosoma cruzi Isolado de Infecções Humanas no Brasil: Revisão Sistemática / Geographical Distribution of DTUs from Trypanosoma cruzi Isolated from Human Infections in Brazil: Systematic Review

Cunha, Marcela Lemes Marquez Da; Lima, Luís Henrique da Silva; Ribeiro, Luana Oliveira; Pires, Thaisla Mendes; Cembranelli, Sibeli Bonafé Santos; Nunes, Poliana Lucena; Oliveira, Sandra Maria Alkmim

doi:10.34117/bjdv8n2-324

Cited by 2 publications

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“…According to molecular genetics, eco-epidemiological and pathogenicity features, T. cruzi populations have been classified into at least seven discrete typing units (DTUs) [ 7 , 8 , 9 , 10 ] and susceptibility to reference drugs can vary among T. cruzi strains [ 11 , 12 ]. In this worrisome scenario, the search for new drugs against Chagas disease is important, especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi

et al. 2023

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Chagas disease is a neglected tropical disease that affects more than 8 million people. Although there are therapies against this disease, the search for new drugs is important because the current treatments show limited effectiveness and high toxicity. In this work, eighteen dihydrobenzofuran-type neolignans (DBNs) and two benzofuran-type neolignans (BNs) were synthesized and evaluated against amastigote forms of two Trypanosoma cruzi strains. The in vitro cytotoxicity and hemolytic activity of the most active compounds were also evaluated and their relationships with T. cruzi tubulin DBNs were investigated by an in silico approach. Four DBNs demonstrated activity against the T. cruzi Tulahuen lac-Z strain (IC50 from 7.96 to 21.12 µM), and DBN 1 exhibited the highest activity against the amastigote forms of the T. cruzi Y strain (IC50 3.26 μM). Compounds 1–4 showed CC50 values higher than antitrypanosomal activities, except for DBN 3. All DBNs with antitrypanosomal activity demonstrated CH50 higher than 100 µM. The in silico results indicated that DBNs 1, 2, and 4 are capable of destabilizing the dynamics of the tubulin-microtubule from the vinca site. These compounds displayed promising in vitro activity against T. cruzi, especially compound 1, and can be considered molecular prototypes for the development of new antiparasitic drugs.

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Section: Introductionmentioning

confidence: 99%

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi

et al. 2023

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“…Tsh 19, belonging to the TcIV molecular group, was a unique finding, as it was not expected. The distribution of the TcIV DTU group in Brazil is concentrated in the northern region, such as in the states of Amapá and Amazonas(CUNHA et al, 2022). Recently, strains Tsh 4 and Tsh 18, belonging to the Tcl group, were isolated from immature and adult stages of T. sherlocki(KUNII et al, 2022).4.7.…”

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confidence: 99%

Fauna Triatomínica Do Estado Do Amazonas: Espécies E Distribuição Geográfica

Silva,

Madeira,

Nepomuceno

et al. 2023

Atualidades Em Medicina Tropical No Brasil: Vetores 2

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The Rhodniini tribe is composed of the genera Rhodnius and Psammolestes. From phylogenetic data, Rhodnius spp. were grouped into three large groups (pallescens, pictipes and prolixus). This genus is considered paraphyletic, since species in the prolixus group are evolutionarily closer to Psammolestes spp. than of the Rhodnius groups. Based on the above, we present a chronological mini-review related to the main phylogenetic and molecular taxonomy studies carried out in the genus Rhodnius. From the data presented, it is clear that: i. the Rhodniini tribe is a monophyletic group; ii. there are three well-defined monophyletic groups in the tribe Rhodniini (prolixus, pictipes and pallescens); iii. the evolutionary relationship between these groups needs to be better defined by phylogenetic studies combining different markers and, above all, increasing intra and interspecific sampling of the genus Rhodnius (with emphasis on species that have never been studied molecularly); iv. the genus Rhodnius is a paraphyletic group in relation to Psammolestes; v. the specific status of some Rhodnius species (such as R. milesi and R. zeledoni) needs to be assessed by integrative taxonomy; vi. paraphyletic lineages of R. robustus need to be described as new species; viii. the strains of R. ecuadoriensis and R. pallescens, as well as Rhodnius aff. R. pictipes from Sierra Nevada, Colombia needs to be studied by integrative taxonomy and described as new species; and, finally, viii. phylogenetic systematics is essential for the taxonomy of Rhodnius.

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Distribuição Geográfica de DTUs do Trypanosoma cruzi Isolado de Infecções Humanas no Brasil: Revisão Sistemática / Geographical Distribution of DTUs from Trypanosoma cruzi Isolated from Human Infections in Brazil: Systematic Review

Cited by 2 publications

References 2 publications

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi

Fauna Triatomínica Do Estado Do Amazonas: Espécies E Distribuição Geográfica

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