Distributed image reconstruction for an in-vivo mouse imaging system

Lee, Sang Chul; Han, Jae Yong; Chun, In Kon; Lee, Soo Yeol; Cho, Min Hyoung

doi:10.1117/12.480006

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…3,4 Intravital microscopy (IVM) was used for the non-invasive continuous monitoring of drug movement in the body 5 as well as the photoacoustic (PA) imaging has been successfully applied to visualize the transport and accumulation of substances in the organ or tumour tissue. 6,7 The laser-induced fluorescence techniques also can be assigned to the group of methods. The diagnostic approach has considerable potential for drug discovery, not only during the development of a new drug formula but also in preclinical and clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive control of rhodamine-loaded capsules distribution in vivo

Stelmashchuk

Tarakanchikova

Seryogina³

et al. 2018

Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX

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Using fluorescence spectroscopy system with the fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group, and the group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in a twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.Keywords: nanocomposite polymeric capsules, fluorescent labelled particles, rhodamine TRITC, drug delivery, fluorescence spectroscopy, blood microcirculation, optical measurements in vivo 1. * o.a.stelmashuk@gmail.com; phone +7 919 269 79 92; www.bmecenter.ru/en/fluorescence_spectroscopy_in_vivo

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Section: Introductionmentioning

confidence: 99%

Noninvasive control of rhodamine-loaded capsules distribution in vivo

Stelmashchuk

Tarakanchikova

Seryogina³

et al. 2018

Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX

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“…In this paper, we have experimentally investigated the application of dielectric layers for reducing dark currents. Four different dielectric layers structures were fabricated using a chemical vapor deposited poly(p-xylylene) polymer parylene C with two photoconductors (PbI 2 and HgI 2 ) [2]. Four kinds of X-ray films were prepared a typical film structure without a dielectric layer, a film with top dielectric, a film with bottom dielectric, and a film with both top and bottom dielectrics.…”

mentioning

confidence: 99%

Improvement in photoconductor film properties by changing dielectric layer structures

Kim

Lee

et al. 2011

J. Inst.

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In recent times, digital X-ray detectors have been actively applied to the medical field; for example, digital radiography offers the potential of improved image quality and provides opportunities for advances in medical image management, computer-aided diagnosis and teleradiology. In this study, two candidate materials (HgI 2 and PbI 2 ) have been employed to study the influence of the dielectric structure on the performance of fabricated X-ray photoconducting films. Parylene C with high permittivity was deposited as a dielectric layer using a parylene deposition system (PDS 2060). The structural and morphological properties of the samples were evaluated field emission scanning electron microscopy and X-ray diffraction. Further, to investigate improvements in the electrical characteristics, a dark current in the dark room and sensitivity to X-ray exposure in the energy range of general radiography diagnosis were measured across the range of the operating voltage. The electric signals varied with the dielectric layer structure of the X-ray films. The PbI 2 film with a bottom dielectric layer showed optimized electric properties. On the other hand, in the case of HgI 2 , the film with a top dielectric layer showed superior electric characteristics. Further, although the sensitivity of the film decreased, the total electrical efficiency of the film improved as a result of the decrease in dark current. When a dielectric layer is deposited on a photoconductor, the properties of the photoconductor, such as hole-electron mobility, should be considered to improve the image quality in digital medical imaging application. In this study, we have thus demonstrated that the use of dielectric layer structures improves the performance of photoconductors.

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Use of fluorescent optical fibre probe for recording parameters of brain metabolism in rat model

Stelmashchuk

Seryogina

Piavchenko

et al. 2018

Biophotonics: Photonic Solutions for Better Health Care VI

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This studiy was carried out on groups of clinically healthy male Wistar rats. Animals received distilled drinking water ad libitum for 1 month, water containing succinic acid, water containing zinc sulphate and succinate zinc. Using the method of fluorescence spectroscopy, the parameters of brain metabolism in vivo in a model of laboratory rats was investigated. Based on data obtained by fluorescence spectroscopy, we have registered a change in the degree of cellular respiration in different structures of the cerebral cortex with the toxic effect of zinc compounds and succinic acid on the oxygen exchange process.Keywords: zinc compounds, succinic acid, zinc sulphate, brain metabolism, fluorescence spectroscopy, blood microcirculation, optical measurements in vivo, neurodegenerative diseases *Olya.zh93@gmail.com; phone 7 919 269 79 92; www.bmecenter.ru/en/vascular-control

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Distributed image reconstruction for an in-vivo mouse imaging system

Cited by 3 publications

References 6 publications

Noninvasive control of rhodamine-loaded capsules distribution in vivo

Noninvasive control of rhodamine-loaded capsules distribution in vivo

Improvement in photoconductor film properties by changing dielectric layer structures

Use of fluorescent optical fibre probe for recording parameters of brain metabolism in rat model

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