Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in pregnant women in Shiraz, Southwest Iran

Omidifar, Navid; Taghi, Erfan; Mohebi, Samane; Motamedifar, Mohammad

doi:10.1016/j.genrep.2020.100731

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…to be extensively resistant43 . A recent study by N. Omidifar et al on antibiotic susceptibility patterns of uropathogens in pregnant women in Iraq reported resistance of 100% and 25% to Ampicillin and Ceftriaxone, respectively in Enterobacter spp., finding similarities in the current study44 . A study by Goel et al in New Delhi revealed a high resistance of Tetracycline and Ciprofloxacin in seven different species of Enterococcus, bearing a resemblance to the results of the present study45 .…”

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confidence: 85%

Untitled

2021

IJPSR

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Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their antibiotic susceptibility patterns in India was conducted through electronic databases including Google Scholar, Directory of Open Access Journals, Web of Science, Elsevier, etc. Search results were evaluated for the appropriateness of being included in the study. A total of 12 reports published from different regions of India were involved in the study. Analysis of data was performed using Comprehensive Meta-Analysis (CMA) software. Results: The most commonly isolated uropathogens were observed to be E. coli, and Klebsiella spp., with a prevalence of 49.6% and 12.8%, respectively. The highest mean resistance was found to be towards Ciprofloxacin, followed by Ampicillin. Resistance patterns in E.coli were found to be more towards Ampicillin (74.11%) and followed by Ciprofloxacin (61.32%). In the other uncommon uropathogens, the highest resistance was recorded towards Ampicillin (62.98%) and Ceftriaxone (62.7%). Conclusions: Over the past years, the resistance levels have been increasing gradually to the traditional drugs used for the treatment of UTI, and hence, a therapy based on the individual culture report and antibiotic sensitivity test is highly encouraged. The use of combinational drugs in the treatment of common infections may help reduce the spiking levels of resistance.

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confidence: 85%

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2021

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“…Regarding the bacterial species obtained in urine cultures in the present study, the most isolated was E. coli followed by S. saprophyticus. The finding of E. coli as the most isolated specie is very common, since most studies about UTI usually report the same (Omidifar et al, 2020;Belete et al, 2020). Belete and Saravanan (2020) performed a study in developing countries about UTI during pregnancy, and found mostly Gram-negative strains, being E. coli the most isolated microorganism (more than 50% of the cases), followed by K. pneumoniae (Belete et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, two E. coli resistant to cephalothin and one resistant to cefuroxime were isolated, first-and second-generation cephalosporins, respectively. In a study conducted by Omidifar et al (2020), it was observed the E. coli as the most common pathogen (78.3%) in cases of UTIs in pregnant women, presenting considerable levels of resistance to cephalosporins (26.1%). In this context, the obtained results should be considered to analyze the main treatment administered to pregnant women with UTI in the BHS studied (cephalexin, a first-generation cephalosporin) as well as help to guide the best treatment option.…”

Section: Discussionmentioning

confidence: 99%

Etiology, frequency and clinical outcomes related to Urinary Tract Infection and Asymptomatic Bacteriuria in pregnant women in a municipality of Southeast Brazil

Alves

Ortiz

Augusto

et al. 2022

RSD

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Objective: The aim of this study was to investigate cases of Urinary tract infection (UTI) and Asymptomatic bacteriuria (ASB) in pregnant women in a Brazilian city, as well as identify the pathogens causing these diseases and its antimicrobial susceptibility profile. Also, we investigated the antibiotic therapy used in pregnant women to treat UTI and ASB, and the comorbidities which can be related to increased risk of these type of infection. Methods: This study was prospective research, descriptive and exploratory, with a qualitative approach, conducted among 35 pregnant women from October 2019 at Basic Health Unit (BHU) in Diadema, São Paulo, Brazil. Patient’s data were obtained using specific terms in the search filters from data base of BHU, as well the results of identification of bacterial species isolated from urine culture and the Antimicrobial Susceptibility Testing (AST). Results: From 35 study participants, 34.3% had a presumptive diagnosis of ASB and 65.7% had a diagnosis of symptomatic UTI. The predominant bacteria isolated were Escherichia coli (n=11) and Staphylococcus saprophyticus (n=2). The AST revealed a low rate of resistance to antimicrobials used for the treatment of UTI. The antimicrobial agents most prescribed was cephalexin. Further, 13 pregnant women presented comorbidities. Also, 20% presented premature delivery and 11,4% babies presented neonatal diseases. Conclusion: In this study, it was possible to know which bacterial species are commonly isolated from pregnant women urine cultures and evaluate the isolates susceptibility profile, as well as analyze the common antimicrobial therapy prescribed to these women.

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“…Este é um estudo retrospectivo documental que avaliou os resultados das culturas de urina no serviço de obstetrícia de um hospital secundário localizado no município de Research, Society and Development, v. 9, n. 8, e862986337, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i8.6337 (Schnarr e Smaill, 2008;Moraes et al 2014;Foxman, 2014;Ballesteros-Monrreal, 2020;Omidifar et al, 2020). Essa alta frequência pode ser explicada pelo fato de sua presença estar relacionada à eliminação fecal e, consequentemente, à contaminação do trato urinário.…”

Section: Metodologiaunclassified

“…Além disso, não há um consenso claro na literatura sobre a escolha de antibióticos ou a duração da terapia para a infecção. Com o aumento da resistência aos antibióticos, é necessário considerar as taxas de resistência local ao escolher a terapia (Omidifar et al, 2020). E, finalmente, a correta associação da UFC com o perfil de resistência das cepas isoladas de gestantes, parece ser um importante ponto de partida para uma escolha mais responsável da terapia.…”

Section: Metodologiaunclassified

Padrões de resistência a antibióticos em enterobactérias isoladas de infecções do trato urinário em gestantes

Stella

Oliveira

2020

RSD

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As infecções do trato urinário (ITU) são infecções geralmente causadas por bactérias Gram-negativas, principalmente enterobactérias, comumente adquiridas na comunidade ou em hospitais. As alterações anatômicas e fisiológicas impostas ao trato urinário pela gravidez podem predispor mulheres bacteriúricas assintomáticas em gestantes com ITUs sintomáticas, portanto investigar a epidemiologia dessas infecções (agentes bacterianos e sensibilidade a antibióticos) durante a gravidez é fundamental para orientar as intervenções. No presente estudo, foi objetivo investigar a presença de enterobactérias causadoras de bacteriúria e ITU em gestantes na cidade de São João do Triunfo-PR de 2015 a 2019. De 176 amostras, foi detectada a presença de Escherichia coli em 95 (54%), das amostras clínicas, Klebsiella sp. em 35 (19,9%), seguida de Proteus sp. 29 (16,5%) e Enterobacter sp 17 (9,6%). Em relação à resistência antimicrobiana, as maiores taxas de multirresistência foram observadas entre os isolados de Escherichia coli, onde 20% dos isolados foram resistentes a quatro ou mais antibióticos e 3,1% dos isolados resistiram a mais de seis agentes antimicrobianos. Klebsiella sp. foi a mais sensível aos antimicrobianos testados, 68,6% foram sensíveis a todos os antibióticos estudados. As infecções causadas por Escherichia coli foram comumente relacionadas a altas contagens de unidades formadoras de colônias (UFC), onde 84,2% das amostras estavam acima de 100.000 UFC/mL, enquanto que a grande maioria das amostras positivas para Klebsiella sp., Enterobacter sp. e Proteus sp. produziram infecções com contagens abaixo de 100.000 UFC/mL, Nossos resultados demonstram que Escherichia coli é a principal enterobactéria que causa ITU em gestantes, principalmente por cepas de resistência a múltiplas drogas, enquanto Klebsiella sp., Enterobacter sp. e Proteus sp. produziu apenas bacteriúria.

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Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in pregnant women in Shiraz, Southwest Iran

Cited by 7 publications

References 20 publications

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Etiology, frequency and clinical outcomes related to Urinary Tract Infection and Asymptomatic Bacteriuria in pregnant women in a municipality of Southeast Brazil

Padrões de resistência a antibióticos em enterobactérias isoladas de infecções do trato urinário em gestantes

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