Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration

Zhang, Xiao‐Yong; Yin, Juan; Cheng, Peng; Hu, Wang; Zhu, Zi‐Zhong; Li, Wenxin; Fan, Chunhai; Huang, Qing

doi:10.1016/j.carbon.2010.11.005

Cited by 642 publications

(455 citation statements)

References 46 publications

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“…administration), [9][10][11][12] being ascribed to the formation of GO-protein complexes that were readily caught by lung capillary vessels. [13][14][15] GO's selective localization in the lung distinguishes it from other types of nanomaterials (mostly in liver and spleen), 16,17 offering a 'guided missile' to target the lung. Nonetheless, many studies have shown that under certain conditions, GO is highly 1 toxic because of its reactive surface groups.…”

Section: Introductionmentioning

confidence: 99%

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

et al. 2018

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Selective targeting plus optimal biocompatibility is still a big challenge in nanomedicine. Although many nanomaterials including graphene oxide (GO) and molybdenum disulfide (MoS 2 ) have been tested for this purpose, these materials possess both favorable features and drawbacks, which hampers their further development. Herein, we prepared MoS 2 /GO nanocomposites that manifested excellent dispersity in aqueous solutions and revealed acceptable biocompatibility in vitro and in vivo. Importantly, MoS 2 /GO displayed a novel feature to selectively target the lung. In other words, MoS 2 /GO manifested a pronounced tendency of localization towards the lung comparable to GO, offering a 'guided missile' effect in targeting the lung. Furthermore, MoS 2 /GO composites possessed enhanced drug loading capacity together with reinforced tumor-killing efficacy against cancer cells that have the propensity to metastasize to the lung. Importantly, MoS 2 /GO composites remarkably repressed metastatic tumor growth of B16 murine melanoma cancer cells in lungs of mice. Mechanistically, MoS 2 /GO was demonstrated to reveal compromised reactions towards macrophages at the nano-bio interface relative to GO, which is accountable for the interaction and the uptake of nanosheets by macrophages associated with phagocytosis and macrophagic activation. Considered together, our findings established new MoS 2 /GO nanocomposites with multi-functionalities including selective lung targeting, favorable drug loading capacity, elevated tumor killing efficacy and improved biocompatibility. Our study opens an avenue for MoS 2 /GO nanocomposites in cancer nanotheranostics.

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Section: Introductionmentioning

confidence: 99%

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

et al. 2018

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“…Owing to these outstanding properties, graphene sheets have been widely applied in different fields such as lithium ion batteries [6][7][8][9], supercapacitors [10][11][12], biomedical materials [13][14][15], and composite materials [16,17].…”

Section: Introductionmentioning

confidence: 99%

Strengthened epoxy resin with hyperbranched polyamine-ester anchored graphene oxide via novel phase transfer approach

Zhang

Liang

Wang

et al. 2017

Adv Compos Hybrid Mater

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This work investigated the mechanical properties of epoxy resin composites embedded with graphene oxide (GO) using a novel two-phase extraction method. The graphene oxide from water phase was transferred into epoxy resin forming homogeneous suspension. Hyperbranched polyamine-ester (HBPE) anchored graphene oxide (GO HBPE ) was prepared by modifying GO with HBPE using a neutralization reaction. Fourier transform-infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM) showed that the HBPE was successfully grafted to the GO surface. The mechanical properties and dynamic mechanical analysis (DMA) of the composites demonstrated that GO HBPE played a critical role in mechanical reinforcement owing to the layered structure of GO, wrinkled topology, surface roughness and surface area ascending from various oxygen groups of GO itself, and the inarching of HBPE and the reaction among GO, HBPE, and epoxy resin. The transferred GO HBPE /epoxy resin composites showed 69.1% higher impact strength, 129.1% more tensile strength, 45.3% larger modulus, and 70.8% higher strain compared to that of cured neat epoxy resin. The glass transition temperature (Tg) of GO HBPE /epoxy resin composites was increased from 135 to 141°C and their damping capacity was also improved from 0.71 to 0.91. This study provides guidelines for the fabrication of strengthened polymer composites using phase transfer approach.

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“…229,231 Mammalian in vivo studies of the toxicity of graphene compounds have been conducted in mice. [243][244][245] In a report by Zhan et al they showed that graphene oxide displays negligible pathological toxicity in most organs, however toxicity in the lungs was observed due to the accumulation and slow clearance of the graphene oxide in the body. 243 It should be noted that the pathological toxicity in the lungs only occurred with large concentrations i.e.…”

Section: Environmental and Biological Toxicity Of Graphenementioning

confidence: 99%

Environmental applications using graphene composites: water remediation and gas adsorption

et al. 2013

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This review deals with wide-ranging environmental studies of graphene-based materials on the adsorption of hazardous materials and photocatalytic degradation of pollutants for water remediation and the physisorption, chemisorption, reactive adsorption, and separation for gas storage. The environmental and biological toxicity of graphene, which is an important issue if graphene composites are to be applied in environmental remediation, is also addressed.

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Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration

Cited by 642 publications

References 46 publications

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Strengthened epoxy resin with hyperbranched polyamine-ester anchored graphene oxide via novel phase transfer approach

Environmental applications using graphene composites: water remediation and gas adsorption

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