Distribution and correlates of non–high-density lipoprotein cholesterol and triglycerides in Lebanese school children

Gannagé‐Yared, Marie‐Hélène; Farah, Vanessa; Chahine, Elise; Balech, Nicole; Ibrahim, Tony; Asmar, Nadia; Barakett-Hamadé, Vanda; Jambart, S

doi:10.1016/j.jacl.2015.12.018

Cited by 9 publications

(17 citation statements)

References 31 publications

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“…In the borderline high risk group and the high risk group, BMI≥95th percentile and parents having TC > 240 mg/dL were significantly associated to dyslipidemia with a P value respectively of .006 and .0001. BMI≥95th percentile was significantly correlated to abnormal level of TG in both groups with a P value of .0001 similar to the study made by Marie-Hélène Gannagé-Yared on 2016 that confirmed the association between obesity and high level of TG [8]. Children with parents having TC > 240 mg/dL was significantly correlated with high TC, high non-HDL-C and high LDL ( P = .0001 for all variables) in both groups, this confirms the genetic predisposition to dyslipidemia in the Lebanese population.…”

Section: Discussionsupporting

confidence: 80%

“…There is a significant correlation between CVD predisposing factors and high level of TC, LDL, TG and low level of HDL-C. While the prevalence of dyslipidemia in adults has been reported to be 10 times higher in Lebanon compared to Western countries, data on the prevalence of dyslipidemic children in Lebanon is lacking [3,8]. After reviewing previous research, the United State National Heart Lung, and Blood institute (NHLBI) expert panel established guidelines that recommend selective screening for children between two and ten years old for lipid disorders in only those with a positive history of some risk factors [19].…”

Section: The Studymentioning

confidence: 99%

“…There are no available data on the prevalence of dyslipidemic children in Lebanon [8]. The predictable prevalence of familial hypercholesterolemia (FH) differs significantly among studies [9].…”

Section: Introductionmentioning

confidence: 99%

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Universal screening program for lipid disorders in 2-10 years old Lebanese children

Georges

Akiki

Naim

et al. 2019

International Journal of Pediatrics and Adolescent Medicine

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IntroductionDyslipidemia has been recognized as a risk factor for cardiovascular diseases. Studies have showed that the development of atherosclerotic lesions begins in childhood and progresses throughout life. While the prevalence of dyslipidemia in adults has been reported to be 10 times higher in Lebanon compared to Western countries, data on the prevalence of dyslipidemic children in Lebanon is lacking.ObjectivesThis study was conducted to assess the benefit of a protocol for universal screening for lipid disorders in Lebanese children aged between two and ten years old.Materials and methodsA total of four hundred children aged 2–10 years old (51.5% boys) were included in the study. The subjects were recruited from private pediatric clinics after parental consent. Fasting total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) levels were measured and non-HDL cholesterol was calculated. The values were categorized according to 2011 Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents.ResultsThe overall prevalence of high TC (≥200 mg/dL), high non-HDL-C (≥145 mg/dL), high LDL (≥130 mg/dL), high TG (≥100 mg/dL) and low HDL (<40 mg/dL) was respectively 19.5%, 23%, 19%, 31.8% and 20%. The overall frequency of dyslipidemia was 51.7%. In a bivariate analysis, dyslipidemia in children was associated with a BMI ≥95th percentile and parents having TC > 240 mg/dL with a P value respectively of .006 and .0001. Furthermore, high TG was independently associated with a BMI ≥95th percentile (P = .0001). Children with parents having TC > 240 mg/dL was significantly correlated with high TC, high non-HDL-C and high LDL (P = .0001 for all variables). Finally, according to the Pediatric Dyslipidemia Screening Guidelines from the 2011 Expert Panel, 62.3% of dyslipidemic children had at least 1 risk factor that qualified them for screening while 37.7% of them didn't have any risk factor.ConclusionsIt is preferable to review the latest pediatric dyslipidemia screening guidelines by performing a universal screening program since a third of our dyslipidemic Lebanese children will be missed.

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Section: Discussionsupporting

confidence: 80%

Section: The Studymentioning

confidence: 99%

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Universal screening program for lipid disorders in 2-10 years old Lebanese children

Georges

Akiki

Naim

et al. 2019

International Journal of Pediatrics and Adolescent Medicine

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“…Population. This cross-sectional study is the continuum of a previous study that was carried on a sample of the Lebanese pediatric population 23 and in which 969 school children were screened for a non fasting lipid profile (TC, triglycerides and HDL-C). In that study, 10 private and public schools were targeted for recruitment using a stratified random sample.…”

Section: Methodsmentioning

confidence: 99%

“…The children's serum samples, collected in 2013-2014, have been stored since at -80 °C, and were used for the Lp(a) analysis which was done in 2018. Eight subjects were excluded from our previous publication 23 because of insufficient serum samples to perform the Lp(a) measurement.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and status of Lipoprotein (a) among Lebanese school children

Gannagé‐Yared

Lahoud

Younes

et al. 2020

Sci Rep

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Lipoprotein a (Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease. The prevalence of high Lipoprotein (a) (Lp(a)) in the Lebanese pediatric population is unknown. Our study aims to assess this prevalence and to study the relationship of Lp(a) with the lipid profile, age, body mass index (BMI) and socio-economic status (SES) in Lebanese schoolchildren. A total of 961 children aged 8–18 years (497 boys and 464 girls) were recruited from ten private and public schools in 2013–2014 using a stratified random sample. Schools were selected from the Greater Beirut and Mount Lebanon areas, and were categorized into three subgroups according to the schools’ SES status (high, medium, low). Lp(a) was assayed in 2018 on samples previously frozen at − 80 °C. Abnormal Lp(a) levels (≥ 75 nmol/L) were observed in 14.4% of the overall sample (13.5% for boys,15.3% of girls p = 0.56). The median of Lp(a) was 20(10–50) in the whole sample with no significant gender difference. No significant relationship was found between Lp(a) and age. However, Lp(a) was significantly correlated with BMI in whole sample, as well as in boys and girls (p = 0.02, p = 0.03, p = 0.03, respectively). A significant correlation was found between Lp(a) and non-HDL-C in the whole sample as well as in boys and girls (respectively p < 0.001,p = 0.024 and p = 0.03), but not with triglycerides and HDL-C. In a multivariate linear regression analysis, Lp(a) was only independently associated with BMI and non-HDL-C in boys and girls. Lp(a) was independently associated with BMI and non-HDL-C while no significant relationship was observed with age and sex confirming the strong genetic determination of Lp(a).

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Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children

Gannagé‐Yared

Sabbagh

Chedid

2018

J Endocrinol Invest

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Distribution and correlates of non–high-density lipoprotein cholesterol and triglycerides in Lebanese school children

Cited by 9 publications

References 31 publications

Universal screening program for lipid disorders in 2-10 years old Lebanese children

Universal screening program for lipid disorders in 2-10 years old Lebanese children

Prevalence and status of Lipoprotein (a) among Lebanese school children

Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children

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