Distribution and density of melatonin receptors in human main pancreatic islet cell types

Zibolka, Juliane; Bazwinsky-Wutschke, Ivonne; Mühlbauer, Eckhard; Peschke, Elmar

doi:10.1111/jpi.12480

Cited by 24 publications

(20 citation statements)

References 77 publications

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“…It is believed that the decreased glucose level in diabetic rat models is attributed to the restoration of pancreatic islet cells by ML [ 71 ]. Melatonin receptors are found in many cells, including pancreatic β-cells and cardiomyocytes, indicating the prevalent effects of MLT on several physiological functions [ 25 ]. It was reported that MLT protects pancreatic β-cells from STZ-induced cellular oxidative injury and the development of T2DM [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the melatonin treated group (MLT), rats were given MLT (10 mg/kg) by stomach tube daily for 15 days between 10:0 and 11:00 am [ 28 ]. The 3 rd group was diabetic group (DM) in which the rats were treated with single dose of nicotinamide following STZ [ 25 ] to develop diabetes. In the fourth group, rats were injected with MLT at 3 rd day after induction of diabetes for 15 days.…”

Section: Methodsmentioning

confidence: 99%

“…MLT influences metabolic disorders including diabetes via the control of insulin release in vivo and in vitro [ 24 ]. MLT regulates the hormone secretion by pancreatic islets of specific, G-protein-coupled melatonin receptor types MT1 and MT2 on main pancreatic islet cells including Beta-cells [ 25 ]. Recently, it is reported that MLT increased proliferation of pancreatic cells through activation of MT2 in vitro [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Abdulwahab

El-Missiry

Shabana

et al. 2021

Heliyon

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Cardiomyopathy and pancreatic injury are health issues associated with type 2 diabetes mellitus (T2DM) and are characterized by elevated oxidative stress, inflammation and apoptosis. Melatonin (MLT) is a hormone with multifunctional antioxidant activity. The protective effects of MLT on the heart and pancreas during the early development of diabetic cardiomyopathy and pancreatic injury were investigated in male Wistar rats with T2DM. MLT (10 mg/kg) was administered daily by gavage for 15 days after diabetic induction. Treatment of diabetic rats with MLT significantly normalized the levels of serum glucose, HbA1-c, and the lipid profile and improved the insulin levels and insulin resistance compared with diabetic rats, affirming its antidiabetic effect. MLT significantly prevented the development of oxidative stress and sustained the levels of glutathione and glutathione peroxidase activity in the heart and pancreas of diabetic animals, indicating its antioxidant capacity. Additionally, MLT prevented the increase in proinflammatory cytokines and expression of Bax, caspase-3 and P53. Furthermore, MLT enhanced the anti-inflammatory cytokine IL-10 and antiapoptotic protein Bcl-2. MLT controlled the levels of troponin T and creatine kinase-MB and lactate dehydrogenase activity, indicating its anti-inflammatory and antiapoptotic effects. Histological examinations confirmed the protective effects of MLT on T2DM-induced injury in the myocardium, pancreas and islets of Langerhans. In conclusion, the protective effects of melatonin on the heart and pancreas during the early development of T2DM are attributed to its antihyperglycemic, antilipidemic and antioxidant influences as well as its remarkable anti-inflammatory and antiapoptotic properties.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Abdulwahab

El-Missiry

Shabana

et al. 2021

Heliyon

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“…First, GWAS have shown that the rs10830963 risk variant of MTNR1B, which confers increased expression of the receptor in human pancreatic islets [15], is associated with impaired fasting glucose, measures of decreased insulin secretion and increased T2D risk [15][16][17][18][19][20]. Furthermore, in vitro, melatonin administration stimulates secretion of somatostatin-an insulin-inhibitory hormone-in human pancreatic islets [21,22]. Also, placebo-controlled human experimental studies have demonstrated that acute melatonin administration worsens glucose tolerance, both in aged women [23] and in young women [24], and both in the morning and in the evening [24].…”

Section: Is Melatonin Deleterious For T2d?mentioning

confidence: 99%

Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

Garaulet

Qian

Florez

et al. 2020

Trends in Endocrinology & Metabolism

127

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The last decade has witnessed a revival of the interest in the hormone melatonin, partly attributable to the discovery that variance in MTNR1B-the melatonin receptor 1b gene-is a risk factor for impaired fasting glucose and type-2-diabetes. Despite intensive investigation, there exists considerable confusion and seemingly conflicting data on the metabolic effects of melatonin and MTNR1B variation, and disagreement on whether melatonin may be metabolically beneficial or deleterious, a critical question for melatonin-agonist/antagonist drug development, and dosing time. We provide a conceptual framework-anchored in the dimensions of "time"-to reconcile paradoxical findings in the literature. We propose that the relative timing between elevated melatonin concentrations and glycemic challenges should be considered in order to better understand the mechanisms and therapeutic opportunities of melatonin signaling in glycemic health and disease. Highlights Melatonin has been investigated mostly for its role in sleep and circadian regulation. The recent discovery of MTNR1B as a novel type 2 diabetes (T2D) gene has sparked great interest in the role of melatonin in glucose control among diabetologists and basic researchers alike. Despite intensive research, there exist conflicting data regarding the effects of melatonin and MTNR1B genotype on glucose control, and disagreement on whether melatonin may increase or decrease fasting glucose, glucose tolerance and T2D risk.

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“…Melatonin acts as a synchronizing agent (zeitgeber) on the islets’ circadian oscillator, inducing a shift in the rhythm of insulin secretion [ 5 , 6 , 12 , 13 ]. The mechanisms of melatonin action on β-cells differ between animals [ 5 , 12 , 13 , 14 ]. In the rat, melatonin negatively affects insulin secretion both in vitro and in vivo [ 5 , 6 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Streptozotocin-Induced Diabetes on the Pineal Gland in the Domestic Pig

Lewczuk

Prusik

Ziółkowska

et al. 2018

IJMS

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Several observations from experiments in rodents and human patients suggest that diabetes affects pineal gland function, including melatonin secretion; however, the accumulated data are not consistent. The aim of the present study was to determine the effects of streptozotocin-induced diabetes on the pineal gland in the domestic pig, a species widely used as a model in various biomedical studies. The study was performed on 10 juvenile pigs, which were divided into two groups: control and diabetic. Diabetes was evoked by administration of streptozotocin (150 mg/kg of body weight). After six weeks, the animals were euthanized between 12.00 and 14.00, and the pineal glands were removed and divided into two equal parts, which were used for biochemical analyses and for preparation of explants for the superfusion culture. The pineal contents (per 100 μg protein) of serotonin, 5-hydroxyindole acetic acid, 5-hydroxytryptophol, 5-methoxyindole acetic acid, 5-methoxytryptophol, and 5-methoxytryptamine were significantly lower in diabetic pigs than in control pigs. In contrast, the level of N-acetylserotonin was significantly higher in diabetic animals. No significant differences were found in the level of melatonin between control and experimental pigs. The amounts of 3,4-dihydroxyphenylalanine, dopamine, norepinephrine, and 3,4-dihydroxyphenylacetic acid were significantly lower in the pineal glands of diabetic animals. The level of vanillylmandelic acid was higher in diabetic pigs. No differences were observed in the level of basal and NE-stimulated release of N-acetylserotonin or melatonin between the pineal explants prepared from control and experimental animals. In vitro treatment with insulin was ineffective. In conclusion, streptozotocin-induced diabetes affects both indole metabolism and adrenergic neurotransmission in the pig pineal gland.

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Distribution and density of melatonin receptors in human main pancreatic islet cell types

Cited by 24 publications

References 77 publications

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

Effects of Streptozotocin-Induced Diabetes on the Pineal Gland in the Domestic Pig

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