Distribution and excretion of radioactive rare-earth compounds in mice

Rosoff, Betty; Siegel, Eliot L.; Williams, Grady L.; Spencer, Herta

doi:10.1016/0020-708x(63)90107-8

Cited by 34 publications

(29 citation statements)

References 9 publications

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“…Inorganic nonchelated REEs are reported to be changed into the colloidal form of hydroxide, phosphate, and carbonate in blood (Rosoff et al, 1963;Kanapilly, 1980;Hirano et al, 1993) 2,4,7,15,and 45 days (Y,Eu,Dy,Yb) or at 20 and 40 min; 1, 2, 4, and 6 hr; and 1, 2, 3, and 7 days (Pr) after administration, the liver, spleen, lungs, kidneys, and femurs were excised and whole blood was obtained. Concentrations of REEs and Ca in the organs were measured by the wet digestion/ICP-AES method.…”

Section: Discussionmentioning

confidence: 99%

Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

et al. 1997

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Section: Discussionmentioning

confidence: 99%

Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

et al. 1997

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“…Rossoff et al (68) (46). Uptake of Y by the liver and spleen also increased with the dose of YCl3 (46).…”

Section: Exposure To Rare Earthsmentioning

confidence: 94%

“…It has been shown that accumulation of Sc3+-citrate (low stability) in the liver, spleen, and bone was much higher than that of Sc3+-EDTA (high stability) following iv injection in mice (68 (69).…”

Section: Exposure To Rare Earthsmentioning

confidence: 99%

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

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“…The distribution and excretion of scandium in mice [4] and man [5,6] were studied and electrophoresis was used to show Sc3+ binding to the p-globulin fraction of plasma [7].…”

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confidence: 99%

The Binding of Scandium Ions to Transferrin in vivo and in vitro

Ford‐Hutchinson

Perkins

1971

Eur J Biochem

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1.Studies on the binding of scandium to human apotransferrin showed that two Sc3+ were 2. The binding of each Sc3f involves the ionisation of two phenolic tyrosyl residues. 3. The scandium * protein complex has similar resistance to denaturants and chemical reagents 4. The only protein complex observed, when quantities ofSc3f below the free iron binding capa-5. The injection of Sc3+, as a 1:2 citrate complex, into rabbits led after 48 h to all the plasma bound specifically a t the two iron-binding sites.as the iron complex. city of serum were added to whole serum in vitro, was the Sc3+ * transferrin complex.Sc3+ being present as the transferrin complex.Previous studies on the metabolism of scandium were initiated through possible hazards arising from its presence in nuclear explosion sites [l], because of its chemical similarity to yttrium and the lanthanides, whose biological properties have been extensively The &globulin, transferrin, in its pure form was shown to bind a number of trivalent metal ions, including scandium [8]. Transferrin was also implicated in the transport of various metals in the plasma, apart from iron, including chromium MATERIALS AND METHODS Materials MethodsDifference spectroscopy readings were taken on a UnicamSPSOO recording spectrophotometerfittedwith a scale expansion unit. All other spectrophotometric readings were taken with a Gilford 2000 spectrophotometer fitted with a Unicam SP500 monochromator. Radioactivity measurements of solutions containing 46Sc or S9Fe were made using a y scintillation spectrometer. All protein concentrations were determined using an E~~~ = 9.23 x lo4 11131 (the on binding Sc3f to tranferrin is less than lo/, as shown below). For binding measurements by gel filtration, apotransferrin (5 ml, 50/, w/v) in 0.1 M Tris-C1 buffer a t the appropriate pH was equilibrated, for either 1 h a t 23 "C or one week a t 4 "C, with a ten-fold excess of Sc3f as a 1 : 2 Sc3f -citrate complex containing 10 pCi of 4 %~. Excess metal was removed on a 35 ~2 cm column of Sephadex G-25 equilibrated with 0.1 M Tris-C1 buffer. Fractions (3 ml) were collected and the protein eluates localised and metal concentrations determined by radioactivity measurements.The scandium -transferrin samples thus obtained (from the longer incubation period only) were passed down a 2 0 x 2 cm column of Chelex 100. Fractions were treated as for the Sephadex 6-25 column.Ultraviolet difference spectra upon metal binding were recorded using dual compartment cuvettes. I n one compartment was placed protein (5O/, w/v) in pH 8.0 0.2 M Tris-C1 buffer; in the other 2.0 mM scandium and 4.0 mM trisodium citrate in the same buffer. For the titration of scandium and apotrans-

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Distribution and excretion of radioactive rare-earth compounds in mice

Cited by 34 publications

References 9 publications

Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

The Binding of Scandium Ions to Transferrin in vivo and in vitro

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