Distribution and Excretion of Radioactive Hafnium181 Sodium Mandelate in the Rat

Cf, Kittle; Er, King; Ct, Bahner; Brucer, Marshall

doi:10.3181/00379727-76-18462

Cited by 16 publications

(4 citation statements)

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“…At 4 d after intravenous administration of 181 Hf mandelate to rats, the median liver:femur and kidney:femur concentration ratios were $6 and 1.4, respectively (MacDonald and Bahner, 1953). At 16 d after intravenous administration of 181 Hf mandelate to rats, the total body, liver, and bone contained $93%, 45%, and 13%, respectively, of the administered activity corrected for radioactive decay (Kittle et al, 1951).…”

Section: Ingestionmentioning

confidence: 99%

“…(459) Klaassen (1979) investigated the behaviour of silver in rats, rabbits, and dogs after intravenous administration of various masses of silver nitrate. Distribution studies on rats indicated that the liver was the dominant repository at early times.…”

Section: Silver (Z = 47)mentioning

confidence: 99%

“…They found that the transport and distribution of silver resemble those of copper in some aspects, particularly with regard to high accumulation in the liver and lactating mammary gland, and the fact that silver attaches to some extent to the copper-carrying protein ceruloplasmin in plasma and milk. However, silver was mainly carried in plasma by a different macroglobulin from that involved in copper transport and, overall, was distributed somewhat differently from copper in tissues. (459) Klaassen (1979) investigated the behaviour of silver in rats, rabbits, and dogs after intravenous administration of various masses of silver nitrate. Distribution studies on rats indicated that the liver was the dominant repository at early times.…”

Section: Silver (Z = 47)mentioning

confidence: 99%

See 2 more Smart Citations

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Paquet¹,

Leggett²,

Blanchardon³

et al. 2022

Ann ICRP

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Section: Ingestionmentioning

confidence: 99%

Section: Silver (Z = 47)mentioning

confidence: 99%

Section: Silver (Z = 47)mentioning

confidence: 99%

See 1 more Smart Citation

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Paquet¹,

Leggett²,

Blanchardon³

et al. 2022

Ann ICRP

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show abstract

“…At 4 d after IV administration of 181 Hf mandelate to rats, the median concentration ratios liver:femur and kidney:femur were ~6 and 1.4, respectively (Macdonald and Bahner 1953). At 16 d after IV administration of 181 Hf mandelate to rats, the total body, liver, and bone contained ~93%, 45%, and 13%, respectively, of the administered activity corrected for radioactive decay (Kittle et al 1951). Berry and Galle (1992) used electron microprobe to study intracellular localisation of Zr and Hf after administration of low doses of soluble salts.…”

Section: Hafniummentioning

confidence: 99%

Biokinetic models for group IVB elements

Leggett

Samuels

2020

J. Radiol. Prot.

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The International Commission on Radiological Protection (ICRP) is updating its biokinetic models in a series of reports titled Occupational Intakes of Radionuclides (OIR series). This paper provides an overview of biokinetic data for the group IVB elements hafnium (Hf) and titanium (Ti), compares these data with findings for the more extensively studied Group IVB element zirconium (Zr), and proposes biokinetic models for systemic Hf and Ti for use in the OIR series. A biokinetic model for systemic Zr recently adopted by the ICRP is proposed for application to Hf in view of the nearly identical chemical and physical properties of these two elements, their closely similar behavior in the environment, and their nearly identical biokinetic properties suggested by available comparative data. The model structure applied to Zr and Hf is also applied to Ti, but a separate set of transfer coefficients is proposed for Ti.

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Zirconium and Hafnium

Bevan¹

2023

Patty's Toxicology

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Zirconium and hafnium belong to the group IVB of the periodic table. A characteristic feature of these transition elements is the ease with which they form stable complex ions. Features that contribute to this ability are favorably high charge‐to‐radius ratios and the availability of unfilled d orbitals. The ability of forming metallic bonds is demonstrated by the existence of a wide variety of alloys among different transition metals. Other features of these metals are high densities, high melting points, and low vapor pressures. Within this group, these properties tend to increase with increasing atomic weight. This chapter discusses the chemical and physical properties followed by the toxicity of each chemical and compound in two sections: the first section provides details on zirconium, and the second section on hafnium.

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Distribution and Excretion of Radioactive Hafnium181 Sodium Mandelate in the Rat

Cited by 16 publications

References 1 publication

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Biokinetic models for group IVB elements

Zirconium and Hafnium

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