Distribution and genetic organization of pathogenicity island XII among the clinical strains of GBS

Kuleshevich, E. V.; Savicheva, Alevtina; Arzhanova, Olga N.; Suvorov, Alexander

doi:10.3103/s0891416813010023

Cited by 3 publications

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References 6 publications

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“…Известно, что многие детерминанты ви-рулентности СГВ локализованы не в ядре генома, а на островах патогенности XII, не-сущего известные гены патогенности sspBl, scpB, lmb [1].…”

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Antibacterial treatment of pregnant women colonized by streptococcus group B

et al. 2017

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Relevance. Streptococcus group B (GBS), Streptococcus agalactiae, are the causative agents of severe infections of the fetus and newborn child. The aim of the study was to investigate the efficacy and safety of antibacterial therapy with the use of amoxicillin with clavulanic acid and josamycin pregnant women with GBS, as well as the impact of antibiotic therapy on perinatal outcomes. Materials and methods. For isolation and identification of Streptococcus and Ureaplasma used bacteriological method of research. The article presents the results of a survey of 99 pregnant women, the urogenital tract, which are colonized by streptococcus group B (GBS) and Ureaplasma, during their pregnancy, delivery and perinatal outcomes. Results. All women were divided into three groups: I group — 29 (29.3%) women, with the presence of GBS in the urogenital tract and treated during pregnancy amoxicillin with clavulanic acid, group II — 24 (24,2%) women with the presence of GBS and Ureaplasma treated during pregnancy josamycin, group III — 46 (46.5%) of women with available GBS, which antibacterial therapy during pregnancy was not conducted. Our results confirmed the data of foreign authors about the high frequency of complications of pregnancy and delivery in women colonized by Streptococcus group B who did not receive antibiotic therapy. Thus it often happened GBS colonization of the skin and mucous membranes of infants, develop in utero infection in children born to these mothers. Conclusion. Upon detection of GBS in the urogenital tract of pregnant women is necessary to carry out antibacterial therapy for the prevention of complications of pregnancy, delivery and intrauterine infection of the fetus. Moreover, in the simultaneous detection of Streptococcus group B and Ureaplasma effective to schedule josamycin (wilprafen), which acts on both of the microorganism.

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Antibacterial treatment of pregnant women colonized by streptococcus group B

et al. 2017

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Clinical strains of Streptococcus agalactiae carry two different variants of pathogenicity island XII

et al. 2017

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Streptococcus agalactiae or Group B streptococci (GBS) are a common cause of serious diseases of newborns and adults. GBS pathogenicity largely depends on genes located on the accessory genome including several pathogenicity islands (PAI). The present paper is focused on the structure and molecular epidemiological analysis of one of the GBS pathogenicity islands-the pathogenicity island PAI XII (Glaser et al. Mol Microbiol 45(6):1499-1513, 2002). This PAI was found to be composed of three different mobile genetic elements: a composite transposon (PAI-C), a genomic islet (PAI-B), and a pathogenicity island associated with gene sspB1 (PAI-A). PAI-A in GBS has a homolog--PAI-A1 with similar, but a different genetic constellation. PCR-based analysis of GBS collections from different countries revealed that a strains lineage with PAI-A is less common than PAI-A1 and was determined to be present only among the strains obtained from Russia. Our results suggest that PAI-A and PAI-A1 have the same progenitor, which evolved independently and appeared in the GBS genome as separate genetic events. Results of this study reflect specific geographical distribution of the GBS strains with the mobile genetic element under study.

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Russian strains of group B streptococci are different in the content and organization of the PAI-A and PAI-A1 pathogenicity islands

et al. 2021

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Group B streptococci, or Streptococcus agalactiae, are the major cause of severe diseases in newborns and adults. The PAI-A and PAI-A1 pathogenicity islands containing the sspB1 and sspB1a genes, respectively, were found among group B streptococci mobile genetic elements. The presence of sspB genes correlates with urogenital tract infections. The aim of this study was to determine the frequency of group B streptococci strains with the PAI-A and PAI-A1 pathogenicity islands, circulating in Moscow, in comparison with strains from St. Petersburg. The sspB1 gene, and hence the PAI-A pathogenicity island, was not found in the genomes of strains from Moscow. The frequency of the sspB1a gene and the PAI-A1 pathogenicity island in the genomes of clinical strains was three times higher than in the genomes of colonizing strains. Thus, it can be assumed that the genes of the sspB family are more specific of group B streptococci colonizing pregnant women and newborns.

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Distribution and genetic organization of pathogenicity island XII among the clinical strains of GBS

Cited by 3 publications

References 6 publications

Antibacterial treatment of pregnant women colonized by streptococcus group B

Antibacterial treatment of pregnant women colonized by streptococcus group B

Clinical strains of Streptococcus agalactiae carry two different variants of pathogenicity island XII

Russian strains of group B streptococci are different in the content and organization of the PAI-A and PAI-A1 pathogenicity islands

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