Distribution and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the Egyptian rousette flying fox, Rousettus aegyptiacus

Maseko, Busisiwe C.; Bourne, James A.; Manger, Paul R.

doi:10.1016/j.jchemneu.2007.05.006

Cited by 53 publications

(40 citation statements)

References 83 publications

(204 reference statements)

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“…The serotonergic nuclei (5HT+) identified in the brains of all three species of this study were found to be the same as other eutherian mammals studied to date (Steinbusch, 1981;Maseko et al, 2007;Dell et al, 2010;Kruger et al, 2012). These nuclei were all located within the brainstem and can be divided into a rostral and caudal cluster.…”

Section: Serotonergic Nucleisupporting

confidence: 61%

“…These nuclei were found in positions typical of all mammals (Woolf, 1991;Manger et al, 2002a;Maseko et al, 2007;Dell et al, 2010;Kruger et al, 2010). The ChAT+ nucleiidentified in the three Afrotherian species studied include: the oculomotor (III), trochlear (IV), motor division of thetrigeminal (Vmot), adbucens (VI), dorsal and ventral subdivisionsof the facial (VIId and VIIv), nucleus ambiguus, dorsal motor vagus(X), hypoglossal (XII), Edinger-Westphal (EW), medullary tegmentalfield (mtf) andthe preganglionic motor neurons of thesalivatory (pVII) and the glossopharyngeal (pIX) nerves (Figs.…”

Section: Cholinergic Cranial Nerve Motor Nucleimentioning

confidence: 92%

“…Maseko et al, 2007;Moon et al, 2007;Dwarika et al, 2008). The RVL began as a lateroventral continuation of 5HT+ neurons from the lower portion of the RMg extending over the pyramidal tracts and consolidating as a distinct column lateral to the inferior olives.…”

Section: Caudal Clustermentioning

confidence: 99%

“…This caudal arc of the DRl was classified as the DRc nucleus. We classified this as anindependent nucleus due to the lack of 5HT+ neurons in this region in the brain of monotremes (Manger et al, 2002b;Maseko et al, 2007;Dell et al, 2010;Kruger et al, 2012).…”

Section: Rostral Clustermentioning

confidence: 99%

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Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species—Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus

Calvey

Patzke

Kaswera

et al. 2013

Journal of Chemical Neuroanatomy

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Paul.Manger@wits.ac.za 2 Highlights  The organisation of four neural systems is described in the brains of three Afrotherians not previously studied  These systems are organised in a similar manner to other mammals.  There are features that reflect both phylogenetic and functional signals in the evolution of these neural systems.  The golden mole appears to be a "hyper-cholinergic" mammal, possessing cholinergic neurons in novel regions of the brain. AbstractThe present study describes the organization of the cholinergic, catecholaminergic, serotonergic and orexinergic (hypocretinergic) neurons in the brains of the giant otter shrew, the Hottentot golden mole and the four-toed sengi, three members of the mammalian super orderAfrotheria. The aim of the present study was to investigate the possible differences in the nuclear complement of these neural systems in comparison to previous studies on other Afrotheria species and other mammalian species. Brains of the golden mole, sengi and giant otter shrew were coronally sectioned and immunohistochemically stained with antibodies against cholineacetyl-transferase, tyrosine hydroxylase, serotonin and orexin-A. The majority of nuclei revealed in the current study were similar between the species investigated, to other Afrotherian species investigated, and to other mammals, but certain differences in the nuclear complement highlighted phylogenetic interrelationships. The golden mole was seen to have cholinergic interneurons in the cerebral cortex, hippocampus, olfactory bulb and amygdala. The four-toed sengi had cholinergic neurons in both colliculi and in the cochlear nucleus, but lacked the catecholaminergic A15d group in the hypothalamus. In both the golden mole and the four-toed sengi, the locus coeruleus (A6d group) was made up of few neurons. The golden mole also exhibited an unusual foreshortening of the brain, such that a major kink in the brainstem was evident. The results of this study, framed in a phylogenetic context, appear to indicate that the golden mole and four-toed sengi share a more recent common ancestor that diverged from the tenrec lineage early in the phylogenetic history of the Afrotherians.

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Section: Serotonergic Nucleisupporting

confidence: 61%

Section: Cholinergic Cranial Nerve Motor Nucleimentioning

confidence: 92%

Section: Caudal Clustermentioning

confidence: 99%

Section: Rostral Clustermentioning

confidence: 99%

See 2 more Smart Citations

Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species—Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus

Calvey

Patzke

Kaswera

et al. 2013

Journal of Chemical Neuroanatomy

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“…Manger, 2005;Maseko et al, 2007;Bhagwandin et al, 2008;Dwarika et al, 2008;Limacher et al, 2008, Gravett et al, 2009, Pieters et al, 2010Bux et al, 2010). In terms of the orexinergic system this appears to hold true for most mammals; however, the observations of variance in the number of potential orexinergic nuclei in rodents (Nixon and Smale, 2007) may indicate greater organizational variance within an order for this diffusely projecting system than other systems previously studied.…”

Section: Introductionmentioning

confidence: 88%

Distribution of orexinergic neurons and their terminal networks in the brains of two species of African mole rats

Bhagwandin

Fuxé

Bennett

et al. 2011

Journal of Chemical Neuroanatomy

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The distribution of orexinergic cell bodies and terminal networks within the brains of two species of African mole rat (Cape-dune mole rat -Bathyergus suillus and highveld mole rat -Cryptomys hottentotus) were identified using immunohistochemistry for Orexin-A.The aim of the study was to investigate possible differences in the nuclear complement and terminal distribution of this system by comparing those of the mole rats to published studies of other rodents and mammals. The wild-caught mole rats used in this study live a subterranean lifestyle and are well known for their regressed visual system, which may lead to the prediction of differences in the distribution of the cell bodies and the terminal networks; however, we found that both species of mole rat displayed orexinergic nuclei limited to the hypothalamus in regions similar to those previously reported for other rodent and mammalian species. No immunoreactive neurons could be identified, in either species of mole rat within the anterior hypothalamic paraventricular nucleus, as has been reported for Murid rodents. The terminal networks, while remaining similar between the species, are more strongly expressed in the Cape-dune mole rat than in the highveld mole rat.

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Volumetric Analysis of the African Elephant Ventricular System

Maskeo

Spocter

Haagensen

et al. 2011

The Anatomical Record

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This study used magnetic resonance imaging (MRI) to determine the volume of the ventricular system in the brain of three adult male African elephants (Loxodonta africana). The ventricular system of the elephant has a volume of $240 mL, an order of magnitude larger than that seen in the adult human. Despite this large size, allometric analysis indicates that the volume of the ventricles in the elephant is what one would expect for a mammal with an $5 kg brain. Interestingly, our comparison with other mammals revealed that primates appear to have small relative ventricular volumes, and that megachiropterans and microchiropterans follow different scaling rules when comparing ventricular volume to brain mass indicating separate phylogenetic histories. The current study provides context for one aspect of the elephant brain in the broader picture of mammalian brain evolution.

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Distribution and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the Egyptian rousette flying fox, Rousettus aegyptiacus

Cited by 53 publications

References 83 publications

Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species—Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus

Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species—Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus

Distribution of orexinergic neurons and their terminal networks in the brains of two species of African mole rats

Volumetric Analysis of the African Elephant Ventricular System

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