Distribution and sources of fatty acids in surface sediments of mangrove ecosystems in the Northern Kerala Coast, India

Resmi, P.; Gireeshkumar, T.R.; Kumar, C. S. Ratheesh; Udayakrishnan, P B; Chandramohanakumar, N.

doi:10.1080/15275922.2021.2006368

Cited by 4 publications

(1 citation statement)

References 64 publications

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“…53 to 0.65 (non-monsoon) and 0.15 to 0.69 (monsoon). Lower values of Chl a to phaeopigments ratio implied the higher sedimentation rate from the overlying water column or relatively faster rate of detritus phytoplankton deposition in the system (Dell'Anno et al 2002;Resmi 2015). The ratio of Chl a / (Chl a + Phaeopigments) varied from 0.34 to 0.39 in non-monsoon and 0.13 to 0.41 in monsoon.Trophic status of the Kole wetlandCharacterisation of trophic status of aquatic ecosystems is of utmost importance to understand the food web linkages, biogeochemical characteristics and water quality of the study region.…”

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confidence: 99%

Composition of sedimentary organic matter in Thrissur Kole wetland, southwest India

Vidya

Rajathy²,

Kumar³

2023

Environ Earth Sci

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Spatio-temporal distribution dynamics of various biochemical components in Thrissur Kole wetland were analysed to assess the quality of organic matter (OM) and trophic status. Thrissur Kole wetland forms the part of the Vembanad wetland system, located in the southwest coast of India. Surface sediment samples were collected from sixteen sites during non-monsoon (February 2019) and monsoon (August 2019) seasons. Concentration of biochemical parameters displayed a trend as follows: total carbohydrates > total protein > tannin & lignin > total lipids. Observed chlorophyll pigment concentration in sediments was as follows: Chl a > Chl b > Chl c (in both seasons). Intermediate values of C/N ratios indicated a mixed origin of OM. Majority of stations exhibited lower values of protein to carbohydrate ratios which revealed the occurrence of aged sedimentary OM. Lower values of lipid to carbohydrate ratio indicated lower nutritional value of the organic content. The lower content of labile OM, low biopolymeric carbon to total organic carbon ratio and low algal contribution to the biopolymeric carbon suggested that a bulk fraction of OM exist as refractory. Trophic state of the wetland system was evaluated as hypertrophic, based on protein and carbohydrate content, biopolymeric carbon and algal contribution to biopolymeric carbon.

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confidence: 99%

Composition of sedimentary organic matter in Thrissur Kole wetland, southwest India

Vidya

Rajathy²,

Kumar³

2023

Environ Earth Sci

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Macroinvertebrate metrics and lipid profiles as potential indicators of land use influence in a high altitude tropical highland stream (Sagana River Basin, Kenya)

Odhiambo,

Ngugi,

Sharma

et al. 2024

Ecological Indicators

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Elucidation of Therapeutic Mechanism of Lipopeptide Iturin A from Bacillus aryabhattai on Lung Cancer Through Integration of Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation and In Vitro Analysis

Yaraguppi,

Bagewadi,

Parsanth

et al. 2024

Preprint

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This study used network pharmacology to evaluate iturin A's mechanism of action on lung cancer. Iturin action targets were gathered using the Swiss Target Prediction and PubChem databases. The Gene Cards database was utilised to gather pertinent target sets for lung cancer, and the drug-disease target intersection was identified as a possible site of iturin activity in lungcancer. Using a target protein-protein interaction (PPI) network constructed with the STRING database, topological network analysis was used to identify the primary target genes of iturin A in lung cancer. Subsequently, Cytoscape 3.7.1 was used to import the data. The Shiny database was used to analyse the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment and Gene Ontology (GO) functional enrichment. Three common targets between lung cancer and iturin A were identified through target intersection. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) may be the primary target of iturin activity on lung cancer, according to the PPI map and topological study. According to molecular docking experiments, iturin A had the highest binding affinity to the target. Later, the phosphatidylinositol 4,5-bisphosphate 3-kinase complexed with Iturin A underwent a 200 ns molecular dynamics simulation within a physiological environment. The results illustrated that the ligand maintained a relatively constant shape throughout the simulation. Iturin A was used to treat human lung cancer A549 cells, and the results of the MTT test demonstrated inhibitory action with an IC50 value of 7.73 µM. This allowed for an assessment of the cell's viability. These findings validated iturin-A as an anticancer agent. The combined insights from our network analysis, in-silico tests, and in vitro analyses collectively underscore the potential efficacy of Iturin A in fighting lung cancer.

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Distribution and sources of fatty acids in surface sediments of mangrove ecosystems in the Northern Kerala Coast, India

Cited by 4 publications

References 64 publications

Composition of sedimentary organic matter in Thrissur Kole wetland, southwest India

Composition of sedimentary organic matter in Thrissur Kole wetland, southwest India

Macroinvertebrate metrics and lipid profiles as potential indicators of land use influence in a high altitude tropical highland stream (Sagana River Basin, Kenya)

Elucidation of Therapeutic Mechanism of Lipopeptide Iturin A from Bacillus aryabhattai on Lung Cancer Through Integration of Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation and In Vitro Analysis

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