2015
DOI: 10.1016/j.jpeds.2015.04.075
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Distribution and Within-Family Specificity of Quantitative Autistic Traits in Patients with Neurofibromatosis Type I

Abstract: Objective To examine the distribution of quantitative autistic traits (QATs) in an independent neurofibromatosis type I (NF1) sample, the relationships between QAT, sex, and attention deficit hyperactivity disorder (ADHD) symptomatology, and to explore evidence for QAT mutational specificity within families. Study design Age-appropriate versions of the Social Responsiveness Scale, second edition and the Conners Adult ADHD Rating Scales were completed for 103 patients with NF1 from the Washington University N… Show more

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Cited by 26 publications
(42 citation statements)
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“…Studies of genetic syndromes often report the proportions of children meeting ASD instrument cutoffs without taking IQ or EBP into account. 4, 6, 1618 Unadjusted comparisons of ASD symptom scores are also commonly made between children with ASD and children with other psychiatric disorders or genetic syndromes who differ significantly on these variables. 4, 5, 19 Furthermore, many studies assessing the relationships between ASD symptoms (or autistic traits) and other behavioral, genetic, and neurobiological variables do not carefully take into account phenotypic characteristics, such as age, IQ, or EBP, as potential confounding factors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Studies of genetic syndromes often report the proportions of children meeting ASD instrument cutoffs without taking IQ or EBP into account. 4, 6, 1618 Unadjusted comparisons of ASD symptom scores are also commonly made between children with ASD and children with other psychiatric disorders or genetic syndromes who differ significantly on these variables. 4, 5, 19 Furthermore, many studies assessing the relationships between ASD symptoms (or autistic traits) and other behavioral, genetic, and neurobiological variables do not carefully take into account phenotypic characteristics, such as age, IQ, or EBP, as potential confounding factors.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, in research studies, ASD symptom scores are commonly analyzed without properly considering how individual characteristics might affect score distributions. 46, 1622 …”
Section: Introductionmentioning
confidence: 99%
“…Anonymized, individual-level primary data were pooled from 6 tertiary referral centers: Washington University School of Medicine 8 ; University of California, San Francisco 9 ; Children’s National Health System 10 ; University Hospital of Leuven 11 ; The University of Manchester 12 ; and The Children’s Hospital at Westmead. For all patients, diagnosis of NF1 was established using the National Institutes of Health diagnostic criteria.…”
Section: Methodsmentioning
confidence: 99%
“…Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and sleep disturbance are also highly prevalent (Hyman et al, 2006; Leschziner et al, 2013; Morris et al, 2016) and can persist throughout life (Constantino et al, 2015; Descheemaeker et al, 2013; Mautner et al, 2015; van Eeghen AM et al, 2013). Furthermore, patients with NF1 are at risk for psychosocial problems.…”
Section: Introductionmentioning
confidence: 99%