Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-minute video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ)=31 pairs, Dizygotic (DZ)=95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test-retest reliability ([intraclass correlation coefficient] ICC=0.704, p<0.000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC=0.863, p<0.000, DZ ICC=0.231, p<0.012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t=−8.588, df=31, p<.000), incrementally improved from 18-24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18-24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development.

Objective To examine the distribution of quantitative autistic traits (QATs) in an independent neurofibromatosis type I (NF1) sample, the relationships between QAT, sex, and attention deficit hyperactivity disorder (ADHD) symptomatology, and to explore evidence for QAT mutational specificity within families. Study design Age-appropriate versions of the Social Responsiveness Scale, second edition and the Conners Adult ADHD Rating Scales were completed for 103 patients with NF1 from the Washington University Neurofibromatosis Center. Results Patients with NF1 exhibited a pathologically shifted unimodal distribution for QAT. Forty-four percent of the subjects exhibited a QAT burden at or above 1 SD from the population mean; 13% scored at or above the extreme first percentile of the general population distribution. Elevations in ADHD symptomatology exhibited a distinct bimodal distribution; however, mean ADHD index scores were equivalent in patients who had been diagnosed in the community with ADHD compared with those who had not. We observed striking within-family associations for QAT, reflected by an Social Responsiveness Scale, second edition intraclass correlation of 0.77 in pairings of first degree relatives with NF1. Conclusions Impairments in reciprocal social behavior and attention affect a large proportion of patients with NF1 throughout life and are often clinically unrecognized. Further exploration of genotype-phenotype correlation is strongly warranted for the purpose of gaining insights into mechanisms by which specific mutational variations in the NF1 gene may influence autistic trait severity.

A353Poster presentations rating of 3.5/5); 47% of them received no ratings. There was no relationship between download frequency and rating; the most downloaded app (10k-50k downloads) received 20 reviews. Conclusion Our study indicates that as yet, there are no fully functional apps that support the user throughout the entire pathway of STI awareness, testing, diagnosis management, prescription, partner notification and health promotion. There is a pressing need for sexual health apps which are validated and certified based on reliable content and meet high operability, privacy and security standards to appropriately exploit the potential health care benefits of mobile sexual health.DeveloPment of a Small-meDia intervention to BooSt HealtHcare ProviDerS' KnowleDge anD awareneSS of SyPHiliS in an UrBan US commUnity

Instructions for Section I: You are about to view a brief video segment that shows the social behaviors of a child who has not yet begun to talk (other than a few simple words). Then you will complete a series of questions, some of which ask you to compare your child's behavior to the child in the video. In comparison to the child in the video, Not at all Somewhat but less than child in video About the same as child in video More than child in video

The classic triad of fever, neck stiffness, and altered mentation is the exception, not the rule, in disseminated Neisseria meningitis, and the constellation of symptoms can be disparate and nonspecific. This disease is uncommon with significant morbidity and mortality, making early diagnosis and treatment critical. Here we describe a case of pericarditis and tamponade related to disseminated meningococcemia.