Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Xiang, Fu; Guan, Qing; Liu, Xinwen; Xiao, Han; Xiao, Qian; Liu, Xiuzhen; Sun, Hong; Song, Xiaojie; Zhong, Yuanyuan; Yuan, Chunhui; Xiang, Yun

doi:10.1002/jcla.22581

Cited by 36 publications

(43 citation statements)

References 39 publications

(117 reference statements)

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“…In Fujian province, the main genotypes of HR HPV were HPV16, 52, 58, 53, and 33 . In Hubei province, the main genotypes of HR HPV were HPV 52, 16, 58, 39, and 51 . Interestingly, our results were also different from previous data from Meizhou city in northeastern Guangdong, which showed that the top five HR HPV genotypes were HPV16, 52, 58, 18, and 53 .…”

Section: Discussioncontrasting

confidence: 99%

“…The HPV infection rate varies markedly in China due to its large population and territory. Our results showed that the prevalent detection of any HPV subtypes among gynecological outpatients in Guangdong was 20.16%, which was higher than HPV prevalence in Hubei (17.68%) and lower than that in Fujian (38.3%) and Zhejiang (22.3%) . Considering the same laboratory method (Chaozhou Hybribio Limited Corporation, Chaozhou, China) in HPV detection among these studies, the diversity in HPV prevalence might mainly be attributed to geographical variation.…”

Section: Discussionmentioning

confidence: 57%

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Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Luo

Sun

et al. 2019

Journal of Medical Virology

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Our study aimed to analyze genotype‐specific, age‐specific prevalence, and year‐on‐year trend of cervical human papillomavirus (HPV) detection among women in Guangdong, China 2008 to 2017. A total of 199 963 women attending the gynecological department and 11 999 women attending the medical examination center at Guangdong Women and Children Hospital were included. Prevalent HPV detection significantly differed between these two groups of women (20.16% vs 17.25%; P < .001). HPV genotypes of these two populations have a large overlap, with HPV52, 16, 58, CP8304, and 53 being the dominant subtypes among gynecological outpatients and HPV52, CP8304, 58, 53, and 16 among women receiving physical examinations. The distribution of prevalent HPV detection showed a bimodal pattern across age groups among these two populations. However, prevalent HPV detection among these two populations exhibited different trends from 2008 to 2017. Our study demonstrated that prevalent HPV detection among women in Guangdong is associated with age and different from that among women from other regions of China. Our study may provide valuable data to inform cervical cancer screening and HPV vaccination programs for women in this province.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 57%

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Luo

Sun

et al. 2019

Journal of Medical Virology

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“…The HPV prevalence among women in Dali Bai Autonomous Prefecture (7.6%) was lower than previous studied reported the prevalence rate in the Shangri‐le, Lijiang, and other northwest regions of Yunnan (26.3%, 10.9%, and 18.0%, respectively) . In addition, the HPV prevalence was lower than that reported for most areas in China, such as Guizhou (15.1%), Jiangxi (22.49%), Shanghai (18.98%), Wuhan (17.68%), Tianjin (14.71%), and Guangzhou (12.32%) . Furthermore, the HPV prevalence in Dali area was also lower than the global prevalence of 11.7% .…”

Section: Discussionmentioning

confidence: 58%

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Zhou

et al. 2019

Journal of Medical Virology

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Accumulating evidence indicates that persistent infection with high-risk oncogenic human papillomavirus (HPV) genotypes is the most important risk factor for cervical cancer, and that the distribution of HPV genotypes varies regionally. This study explored the prevalence and genotype distribution of HPV infection among Han, Yi, and Bai women in various regions of Dali Bai Autonomous Prefecture, Yunnan Province, China. This cross-sectional study included 2779 women (20-76 years old) who were referred for 21-HPV genotype array diagnostic from five regions of Dali Bai Autonomous Prefecture between February 2013 and May 2016. Statistical methods used included a the χ 2 test, Fisherʼs exact test, t test, and logistic regression.Overall HPV prevalence in the study population was 7.6%. HPV-52, HPV-58, HPV-18, HPV-81, and HPV-16 were the most prevalent genotypes in the study area, and notably, the prevalence of HPV-58 was significantly higher among women in Heqing County than that in other regions. Univariate analysis showed that husband's age, region, fertility status, and parity were potential factors associated with HPV infection. Multivariate logistic regression analysis revealed that Heqing County was an independent risk factor for HPV infection among women in the Dali area, moreover, Yi women showed the highest risk for HPV infections. Overall, our finding emphasizing the urgent need for an HPV screening and prevention program in Heqing County and Yi women. We also suggest that HPV-related health education should be provided not only to women, but also to men, to reduce the risk of infection in women. K E Y W O R D S epidemiology, ethnic, genotype distribution, human papillomavirus

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“…The previous studies from different areas in China proved that the overall HPV infection rates were 22.4%, 38.3%, 17.6%, and 24.1%, respectively. However, our research suggested that the overall prevalence of HPV infection was 74.0% among the HSIL and ICC women.…”

Section: Discussionmentioning

confidence: 92%

Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

Liao

Cheng

Zeng³

et al. 2018

Clinical Laboratory Analysis

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Background Human papillomavirus (HPV) infection can lead to the development of cervical cancer. This study assessed the genotype distribution of HPV of high‐grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer (ICC) in Ganzhou population. Methods A total of 935 females who got HPV testing from January 2016 to July 2018 in the maternal and child health hospital of Ganzhou were enrolled in the study, including 806 HSIL and 129 ICC. HPV detection and genotyping were tested by HPV Geno‐Array test kit. Results The overall HPV‐positive rate was 74.0% in Ganzhou. Among the HSIL and ICC patients, the positive rates of HPV detection were 75.6% and 64.3%. Among the HSIL individuals, the most prevalent hr‐HPV genotype was HPV 16. And the 4 common subtypes in decreasing order were HPV 52, 58, 33, and 18. Of the ICC patients, the most frequently hr‐HPV subtype was HPV 16 followed by 18, 52, 58, and 59. Among the squamous cell carcinoma (SCC) patients, for hr‐HPV genotypes, HPV 16, 18, 52, 58, and 59 were five most common subtypes. In patients with adenocarcinoma (ADC), the most common hr‐HPV genotype was HPV 18, followed by HPV 16, 52, 56, 68, 73. And, we found U‐shaped and S‐shaped curves in the HPV distribution of different age groups. Conclusion The prevalence and distribution of HPV genotypes in Ganzhou differed from other regions of China and Western countries. These results can serve as valuable reference for HPV vaccination programs for Ganzhou women.

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Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Cited by 36 publications

References 39 publications

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

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