Distribution, dynamics and antibiotic resistance patterns of Streptococcus pneumoniae serotypes causing acute otitis media in children in southern Israel during the 10 year-period before the introduction of the 7-valent pneumococcal conjugate vaccine

Somech, Ido; Dagan, Ron; Givon-Lavi, Noga; Porat, Nurith; Raiz, Simon; Leiberman, Alberto; Puterman, Mark; Peled, Nechama; Greenberg, David; Leibovitz, Eugene

doi:10.1016/j.vaccine.2011.03.103

Cited by 26 publications

(8 citation statements)

References 45 publications

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“…Today, however, penicillin resistance varies from 5-60% in various parts of the world (13,14). Of particular concern is the increase in multidrugresistant S. pneumoniae strains demonstrating resistance to three or more drug classes (15)(16)(17)(18), which creates substantial concerns about both the efficacy of current antibiotic regimens and the continual development of resistance. In addition, the formation of S. pneumoniae biofilm during colonization provides a barrier to effective antibiotic activity (19)(20)(21)(22)(23), thus limiting complete bacterial clearance and promoting the development of resistance (24,25).…”

mentioning

confidence: 99%

Directed vaccination against pneumococcal disease

Hill

Beitelshees

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a “smart” vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.

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mentioning

confidence: 99%

Directed vaccination against pneumococcal disease

Hill

Beitelshees

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Furthermore, the presence of atopic disease was not significantly associated with time-to-resolution of symptoms in the multivariat model. Finally, based on data collected after introduction of the PCV7, 13–17 we expect that with the introduction of the PCV13, the proportion of disease caused by S. pneumoniae will decrease, by eliminating disease caused by serotypes included in the vaccine at least temporarily However, this reduction is likely to be modest because slightly more than one-half of cases were colonized with non-PCV13 serotypes. Accordingly, colonization with S. pneumoniae will likely remain an important prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Predicting Response to Antimicrobial Therapy in Children with Acute Sinusitis

Shaikh

Wald

Jeong

et al. 2014

The Journal of Pediatrics

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Objective To determine prognostic factors that independently predict response to antimicrobial therapy in children with acute sinusitis. Study design 206 children meeting a priori clinical criteria for acute sinusitis who were given antimicrobial therapy by their primary care provider were included. The severity of symptoms in the 8 to 12 days after treatment was initiated was followed using a validated scale. We examined the univariate and multivariate association between factors present at the time of diagnosis (symptoms, signs, nasopharyngeal culture result, radiograph results) and time to resolution of symptoms. This study was conducted 8 to 10 years after 7-valent pneumococcal conjugate vaccination was introduced, but before introduction of the 13-valent pneumococcal conjugate vaccination. Results Children with proven nasopharyngeal colonization with Streptococcus pneumoniae improved more rapidly (6.5 vs. 8.5 median days to symptom resolution) than those who were not colonized with S. pneumoniae. Age and radiograph findings did not predict time to symptom resolution. Conclusions In children with acute sinusitis, proven nasopharyngeal colonization with S. pneumoniae at presentation independently predicted time to symptom resolution. Future randomized, placebo-controlled trials could investigate the usefulness of testing for the presence of nasopharyngeal pathogens as a predictor of response to treatment.

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“…The predicted PCV7 and PCV10 effectiveness among the Israelis are 53.6% and 59.3% respectively and the proportion is further enhanced by approximately 20% with PCV13, mainly due to the inclusion of three prevailing PCV13-VT. Children under 2 years of age accounted for the great majority (90%) of AOM patients among all children aged 5 and less [134]. The author noted the ethnic-dependent differences in serotype distribution, where serotype 14 was common among the Jewish children but serotype 19F was the dominant one among Bedouin children [134]. Thus, the predicted PCVs coverage also differed between them with Bedouin children having 10% lower protection than the Jewish children.…”

Section: Israelmentioning

confidence: 98%

“…A study performed by Somech et al [134] investigated into the serotypes causing pediatric AOM in Southern Israel. Although the isolates under studied were from noninvasive middle ear fluid and does not represent the more invasive serotypes, the data was used to reflect partly the current overall serotype distribution in Israel.…”

Section: Israelmentioning

confidence: 99%

“…Thus, the predicted PCVs coverage also differed between them with Bedouin children having 10% lower protection than the Jewish children. On the other hand, reduction in cotrimoxazole nonsusceptibility over years was accompanied with the concurrent increase in macrolide-resistance as well as the proportions of MDR strains [134]. This is speculated to be due, in part, to the decreased usage of cotromoxazole in southern Israel.…”

Section: Israelmentioning

confidence: 99%

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Current Trend in Pneumococcal Serotype Distribution in Asia

Le¹,

Yusof²,

Sekaran³

2014

J Vaccines Vaccin

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Asia is one of the continents in the world heavily impacted by pneumococcal diseases but yet the information on disease burden and serotype distribution remained largely unclear. The data is essentially needed to inform the burden of pneumococcal diseases as a priority public health concern among the Asian countries. The formulations of pneumococcal conjugate vaccines (PCV) included a number of prevailing serotypes in the Western world but geographical and temporal variations of vaccination effectiveness could be expected in Asia. This review focuses specifically on the most recent five years trend in serotype distributions from both invasive and non-invasive pneumococcal diseases in Asia. Other important features such as antimicrobial resistance and associated clones were also noted. All latest studies reported that complied with the scopes of this review were included and the serotyping data were extracted for comparison analysis between countries, regions, and to represent Asia as the whole. The most common serotypes detected in highest to lowest frequencies order are 19F, 14, 23F, 6B, 19A, 3, and 6A, accounted for approximate two third of the incidences. Heptavalent PCV (PCV7) is expected to cover half of the incidences with significant increment in efficacy with PCV13. East Asia, Southeast Asia, and West Asia have relatively similar serotype distributions though slight variations were observed. The more unique pattern is noted in South Asia region. Initiation of surveillance study in countries with no reporting data is needed. Continued surveillance involving nationwide or multinational collaborative networks need to be set up to enhance and standardize the reporting incidences.

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Distribution, dynamics and antibiotic resistance patterns of Streptococcus pneumoniae serotypes causing acute otitis media in children in southern Israel during the 10 year-period before the introduction of the 7-valent pneumococcal conjugate vaccine

Cited by 26 publications

References 45 publications

Directed vaccination against pneumococcal disease

Directed vaccination against pneumococcal disease

Predicting Response to Antimicrobial Therapy in Children with Acute Sinusitis

Current Trend in Pneumococcal Serotype Distribution in Asia

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