Distribution in Tissue and Seasonal Variation of Norovirus Genogroup I and II Ligands in Oysters

Maalouf, Haifa; Zakhour, M.; Pendu, Jacques Le; Saux, Jean-Claude Le; Atmar, Robert L.; Guyader, Françoise S. Le

doi:10.1128/aem.00148-10

Cited by 127 publications

(99 citation statements)

References 56 publications

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“…SENG-6 are the binding sites of NoVLPs. The A antigen has also been found in HBGA-like substances in the digestive tissues of oysters (32), and the critical role of the terminal N-acetyl-galactosamine residue in the strain-dependent accumulation of HuNoVs in oysters has been discussed previously (29,30). Bacterial A-like substances can also affect the genotype-dependent fate of HuNoVs in the environment because each HuNoV genotype has its own HBGA binding profile (12).…”

Section: Resultsmentioning

confidence: 99%

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Histo-Blood Group Antigen-Like Substances of Human Enteric Bacteria as Specific Adsorbents for Human Noroviruses

Miura

Sano

Suenaga

et al. 2013

J Virol

170

183

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bHisto-blood group antigens (HBGAs) have been suggested to be receptors or coreceptors for human noroviruses (HuNoVs) expressed on the intestinal epithelium. We isolated an enteric bacterium strain (SENG-6), closely related to Enterobacter cloacae, bearing HBGA-like substances from a fecal sample of a healthy individual by using a biopanning technique with anti-HBGA antibodies. The binding capacities of four genotypes of norovirus-like particles (NoVLPs) to Enterobacter sp. SENG-6 cells were confirmed by enzyme-linked immunosorbent assay (ELISA). Transmission electron microscopy demonstrated that NoVLPs bound mainly to extracellular polymeric substances (EPS) of Enterobacter sp. SENG-6, where the HBGA-like substances were localized. EPS that contained HBGA-like substances extracted from Enterobacter sp. SENG-6 was shown by enzyme-linked immunosorbent assay (ELISA) to be capable of binding to NoVLPs of a GI.1 wild-type strain (8fIIa) and a GII.6 strain that can recognize A antigen but not to an NoVLP GI.1 mutant strain (W375A) that loses the ability to bind to A antigen. Enzymatic cleavage of terminal N-acetyl-galactosamine residues in the bacterial EPS weakened bacterial EPS binding to the GI.1 wild-type strain (8fIIa). These results indicate that A-like substances in the bacterial EPS play a key role in binding to NoVLPs. Since the specific binding of HuNoVs to HBGA-positive enteric bacteria is likely to affect the transmission and infection processes of HuNoVs in their hosts and in the environment, further studies of human enteric bacteria and their binding capacity to HuNoVs will provide a new scientific platform for understanding interactions between two types of microbes that were previously regarded as biologically unrelated.

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Section: Resultsmentioning

confidence: 99%

“…While GII.4 NoVLPs bound to S. epidermidis ATCC 35984 ( Fig. 2A), it was previously shown that this genotype recognizes a broad range of ligands other than HBGAs, such as those containing sialic acid (29)(30)(31).…”

Section: Resultsmentioning

confidence: 99%

Histo-Blood Group Antigen-Like Substances of Human Enteric Bacteria as Specific Adsorbents for Human Noroviruses

Miura

Sano

Suenaga

et al. 2013

J Virol

170

183

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“…It is currently demonstrated that NoV particles bind to glycan ligands, some being very similar to human histo-blood group antigen-like (HBGA) carbohydrates in the digestive tissue of shellfish and may account for the inefficiency of depuration practices (Le Guyader et al, 2006b;Maalouf et al, 2010b).…”

Section: Efficacy Of Decontamination Methods On Fresh Producementioning

confidence: 99%

“…In this case NoV monitoring by PCR provided an effective assessment of virus risk and permitted effective risk management controls to be implemented. However some specific binding may influence these results depending on the strains and the shellfish species (Maalouf et al, 2010b;Zakhour et al, 2010). The use of PCR for monitoring virus risk is now the main focus for development of more effective control measures internationally.…”

Section: Evaluation Of the Efficacy Of Current Preventive Measures Inmentioning

confidence: 99%

Scientific Opinion on an update on the present knowledge on the occurrence and control of foodborne viruses

2011

EFS2

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A review of the biology, epidemiology, diagnosis and public health importance of foodborne viruses was performed. Data needs to support a risk assessment were also identified. In addition possible control options and their anticipated impact to prevent or reduce the number of foodborne viral human infections were identified, including the scientific reasons for and against the establishment of food safety criteria and process hygiene criteria for viruses for certain food categories. Food may be contaminated by virus during all stages of the food supply chain, and transmission can occur by consumption of food contaminated during the production process (primary production, or during further processing), or contaminated by infected food handlers. Transmission of zoonotic viruses (e.g. HEV) can also occur by consumption of products of animal origin. Viruses do not multiply in foods, but may persist for extended periods of time as infectious particles in the environment, or in foods. At the EU-level it is unknown how much viral disease can be attributed to foodborne spread. The relative contribution of different sources (shellfish, fresh produce, food handler including asymptomatic shedders, food handling environment) to foodborne illness has not been determined. The Panel recommends focusing controls on preventive measures to avoid viral contamination rather than trying to remove/inactivate these viruses from food. Also, it is recommended to introduce a microbiological criteria for viruses in bivalve molluscs, unless they are labelled "to be cooked before consumption". The criteria could be used by food business operators to validate their control options. Furthermore, it is recommended to refine the regulatory standards and monitoring approaches in order to improve public health protection. Introduction of virus microbiological criteria for classification of bivalve molluscs production areas should be considered. A virus monitoring programme for compliance with these criteria should be risk based according to the findings of a sanitary survey. KEY WORDSFood borne viruses, Norovirus, Hepatitis, Microbiological criteria, molluscs, fresh produce. SUMMARYThe European Food Safety Authority (EFSA) asked the Panel on Biological Hazards to initiate a self tasking issue with the purpose to provide up-to-date information on the present knowledge on the occurrence and control of foodborne viruses. The BIOHAZ Panel carried out a review of the available information in the scientific literature with regards to the biology, epidemiology, diagnosis and public health importance of foodborne viruses. Where possible the review covered primary production, food harvesting, food processing, and storage/retail until consumption. Data needs to support a risk assessment were also identified. In addition possible control options and their anticipated impact to prevent or reduce the number of foodborne viral human infections were identified including the scientific reasons for and against the establishment of microbiological criteri...

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“…(Le Guyader et al, 2006;Mcleod et al, 2009aMcleod et al, , 2009bTian et al, 2006;Wang et al, 2008), (Maalouf et al, 2010;Nappier et al, 2008). Provost et al (2011) (hematocytes) (acidic digestion) .…”

Section: Real Time Rt-pcrmentioning

confidence: 99%

Defecation of Norovirus from the Oyster Crassostrea gigas by Depuration Following Translocation of the Growing Area

Yu¹,

Park²,

An³

et al. 2016

Korean Journal of Fisheries and Aquatic Sciences

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Distribution in Tissue and Seasonal Variation of Norovirus Genogroup I and II Ligands in Oysters

Cited by 127 publications

References 56 publications

Histo-Blood Group Antigen-Like Substances of Human Enteric Bacteria as Specific Adsorbents for Human Noroviruses

Histo-Blood Group Antigen-Like Substances of Human Enteric Bacteria as Specific Adsorbents for Human Noroviruses

Scientific Opinion on an update on the present knowledge on the occurrence and control of foodborne viruses

Defecation of Norovirus from the Oyster Crassostrea gigas by Depuration Following Translocation of the Growing Area

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