Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration

Abstract

-The present investigation was undertaken to determine the distribution of 1,2-dichloropropane (DCP) in the blood, liver, kidney, lung, and abdominal fat of rats after oral administration. Male rats were orally administered 62 or 125 mg/kg body weight doses of DCP dissolved in corn oil by gavage, and the concentrations in the blood and tissues were measured. The DCP concentration in the abdominal fat was much greater than in the blood and other tissues. Twenty-four-hr after oral administration, DCP could still be detected in the blood and abdominal fat in the 62-mg/kg group, and in the blood, liver, kidney, lung, and abdominal fat in the 125-mg/kg group. Our results are valuable data pertaining to the pharmacokinetics of DCP and to human health risk assessment of oral exposure to DCP.

Acute 1,2-Dichloropropane Poisoning due to Ingestion of Rubber Cement

“…An earlier animal study in mice and rats showed that only inhalation of lethal concentrations of 1, 2-DCP caused significant lung, liver, and kidney damage, while multiple sublethal exposures produced only minor toxic effects 15 . After oral administration, the contents of 1,2-DCP in the rats’ tissues and organs, in order from high to low, were abdominal fat, liver, kidney, lung, and blood 16 . However, there are no such data available for 1,2-DCP causing poisoning or death in humans and the distribution of 1,2-DCP in human tissues.…”

“…15 After oral administration, the contents of 1,2-DCP in the rats' tissues and organs, in order from high to low, were abdominal fat, liver, kidney, lung, and blood. 16 However, there are no such data available for 1,2-DCP causing poisoning or death in humans and the distribution of 1,2-DCP in human tissues. Previous case reports and experimental studies have shown that CNS dysfunction is the main clinical manifestation of 1,2-DCP poisoning and may be accompanied by eye and respiratory irritation, liver and kidney dysfunction, hemolytic anemia, DIC, and skin allergy, with the degree of injury related to the exposure concentration.…”