Distribution of alpha1-fetoprotein in fetal plasma, allantoic fluid, amniotic fluid and maternal plasma of cows

Smith, Katie; Lai, Ping-Chin; Robertson, H. A.; Church, Robert B.; Lorscheider, F. L.

doi:10.1530/jrf.0.0570235

Cited by 30 publications

(20 citation statements)

References 12 publications

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“…Highly significant changes were observed in the concentrations of AFP, with relatively low values at birth and marked increase 1 day after colostrum intake. Smith et al (1979) have demonstrated that the concentrations of AFP in foetal bovine plasma reaches the highest values in the 3-4 th month of foetal period, which is followed by a significant decrease until birth. In our study, the mean concentration of AFP observed in calves at birth was only 0.453 μg/ml.…”

Section: Discussionmentioning

confidence: 98%

“…Considerably higher values were reported by Yamada et al (1995) in newborn puppies at birth (14.08 mg/ml), which had fallen to 0.766 mg/ml at 1 week of age. A possible explanation for this difference is that the placentae in cows have more layers of tissue separating foetal and maternal blood than the placentae in other species (Smith et al 1979). Blohm et al (1998) the physiological effect on the foetal tissues changing from an intrauterine to an extrauterine environment with a decrease in the production of foetal proteins in the liver.…”

Section: Discussionmentioning

confidence: 99%

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The concentrations of selected blood serum proteins in calves during the first three months of life

et al. 2016

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This study was aimed at the evaluation of changes in the concentrations of selected blood serum proteins in calves during the first three months of life, including precolostral, colostral, milk, transitional and solid feeding period. Nine clinically healthy calves were used in this study. The first blood sampling was performed before the colostrum intake (day 0) and then at 1, 2, 7, 14, 30, 60, and 90 days of age. Blood serum was analyzed for the concentrations of α 1 -fetoprotein, prealbumin, transferrin, and lactoferrin. The results showed significant changes in the serum concentrations of all the evaluated proteins in calves during the first three months of life (P < 0.01 and P < 0.001). At birth, the mean concentration of α 1 -fetoprotein was low and increased more than × 8 at one day after colostrum intake, then a gradual decrease was found up to day 30 of life. Similar tendency was observed in the concentrations of prealbumin and lactoferrin. While the concentrations of prealbumin increased approximately × 3.5 at one day after colostrum intake, the serum lactoferrin values showed approximately 1.5-fold increase. A subsequent gradual decrease from the 2 nd day of life was found for both prealbumin and lactoferrin. In the concentrations of transferrin, a significant increase was observed on day 7 (P < 0.05). The highest values were found at the age of 14 and 30 days. These results suggest that concentrations of these proteins in calves are markedly altered during the postnatal period, which should be taken into consideration for their precise interpretation in young animals.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The concentrations of selected blood serum proteins in calves during the first three months of life

et al. 2016

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“…However, several neoplastic cell lines of different ori gin have the property of incorporate AFP [27][28][29] and this incorporation occurs through specific membrane receptors [29][30][31][32], The developmental changes and tissue differences in AFP uptake could be ex plained if AFP receptors were also expressed by developing normal cells. In the case of serum albumin, several reports have de scribed the presence of albumin receptors in tissues such as heart [33], liver [34], white adipose tissue [34], kidney [35] and endothe lium [36], It is well known that AFP crosses the pla cental barrier from the fetus to the mother and is found in the maternal plasma during gestation [8,24,37], In an extensive study. Sell and Alexander [24] found that radiola belled AFP injected into pregnant rats also appeared in fetuses and that the half-life of radiolabelled AFP and albumin were consid erably lower in pregnant than in lactating or normal rats.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Fetoprotein and Albumin Uptake by Mouse Tissues during Development

Laborda

Naval²,

Calvo³

et al. 1989

Neonatology

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We have studied the evolution of the incorporation of alpha-fetoprotein (AFP) and albumin by mouse tissues from fetal to adult life. Mice were injected with ¹²⁵I-labelled AFP or albumin and, 3 h later, blood and organs were removed and analyzed for their radioactive protein content. Results showed that all immature tissues examined took up both AFP and albumin from blood. AFP uptake was higher during fetal and early postnatal life and decreased with age. In general, the relative uptake of albumin was lower than that of AFP, and the time-course incorporation of both proteins was parallel in brain, liver and kidney. In other tissues such as white adipose tissue, brown adipose tissue and skin, AFP uptake decreased while albumin uptake remained almost constant or increased with age. In the fetal period, the strong AFP uptake in white adipose tissue contrasted with the much lower albumin incorporation by this tissue. Autoradiographs from sections of organs and entire animals confirmed the cytoplasmic localization of AFP and albumin. We conclude that AFP and albumin found in developing tissues, except for fetal liver and yolk sac, proceed mostly from blood uptake. These results agree with recent experimental data suggesting that the major physiological role of AFP is the transport and delivery of polyunsaturated fatty acids to developing tissues.

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“…The most predominant of three fetus-specific proteins in cattle is ,-fetoprotein (Lai, Peters & Lorscheider, 1978), and the distribution of this protein has been reported in bovine fetal fluids from 42 days until full-term birth at 284 days (Smith, Lai, Robertson, Church & Lorscheider, 1979). Since methods are now available for the collection of pre-implantation embryos in cows (Church & Shea, 1977), the objectives of the present investigation were to establish the time of onset of AFP synthesis during early bovine embryogenesis, and specifically to determine whether implantation and placentation precede expression of the AFP gene.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of alpha-fetoprotein by the pre-implantation and post-implantation bovine embryo

Janzen¹,

Mably²,

Tamaoki³

et al. 1982

Reproduction

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Distribution of alpha1-fetoprotein in fetal plasma, allantoic fluid, amniotic fluid and maternal plasma of cows

Cited by 30 publications

References 12 publications

The concentrations of selected blood serum proteins in calves during the first three months of life

The concentrations of selected blood serum proteins in calves during the first three months of life

Alpha-Fetoprotein and Albumin Uptake by Mouse Tissues during Development

Synthesis of alpha-fetoprotein by the pre-implantation and post-implantation bovine embryo

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