Distribution of Blood Groups in the East African Somali Population

Sistonen, Pertti; Koistinen, J.; Abdulle, O. Aden

doi:10.1159/000153722

Cited by 16 publications

(17 citation statements)

References 14 publications

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“…Occasional reports of P. vivax in Kenya have commonly been ascribed, a priori, either to confusion with the morphologically similar P. ovale or to the genetic contribution from Hametic or other populations who are largely Duffy positive. 6,7 We report here, however, evidence that a parasite having molecular and antigenic characteristics specific for P. vivax is being transmitted among Fy a−b− indigenes of western Kenya. We were first alerted to this possibility when four wild Anopheles, among a group being used to validate a new dipstick assay, 8 consistently gave positive results for P. vivax circumsporozoite protein, phenotype VK 247.…”

Section: Introductionmentioning

confidence: 56%

Evidence for Transmission of Plasmodium Vivax Among a Duffy Antigen Negative Population in Western Kenya

Ryan¹,

Stoute²,

Amon³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

199

156

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Abstract. We present evidence that a parasite with characteristics of Plasmodium vivax is being transmitted among Duffy blood group-negative inhabitants of Kenya. Thirty-two of 4,901 Anopheles gambiae and An. funestus (0.65%) collected in Nyanza Province were ELISA positive for the P. vivax circumsporozoite protein VK 247. All positives were found late in the rainy season, when An. funestus predominated, and disproportionately many were found at a single village. A P. vivax specific sequence of the SSU rRNA gene was amplified from three of six ELISA-positive mosquitoes. Erythrocytes from 31 children, including 9 microscopically diagnosed as infected with P. vivax, were negative by flow cytometry for the Fy3 or Fy6 epitopes, which indicate Duffy blood group expression. A DNA fragment specific for the C terminus of the gene for P. vivax merozoite surface protein 1 (MSP-1) was amplified from the blood of four of these children and subsequently sequenced from two.

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Section: Introductionmentioning

confidence: 56%

Evidence for Transmission of Plasmodium Vivax Among a Duffy Antigen Negative Population in Western Kenya

Ryan¹,

Stoute²,

Amon³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

199

156

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“…Variation in antigen frequency of blood group antigens among racial and ethnic groups in different populations in Africa, Asia, Europe, North America and South America has been reported (Sistonen et al, 1987;Harmening, 1989;Reid & Lomas-Francis, 2007;Reid et al, 2012;Makroo et al, 2013). China, as a large, united, multinational state, is composed of more than 50 ethnic groups of which the Han population accounts for 91.59% of the overall population (Chu et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Frequencies of red blood cell major blood group antigens and phenotypes in the Chinese Han population from Mainland China

Sun

et al. 2016

Int J Immunogenetics

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Alloantibodies directed to red blood cell (RBC) antigens play an important role in alloimmune-mediated haemolytic transfusion reactions and haemolytic disease of the foetus and newborn. The frequencies and phenotypes of RBC antigens are different in populations from different geographic areas and races. However, the data on major blood group antigens in the Chinese Han population from Mainland China are still very limited; thus, we aimed to investigate them in this study. A total of 1412 unrelated voluntary Chinese Han blood donors were randomly recruited. All donors were typed for blood group antigens: D, C, c, E, e, C(w) , Jk(a) , Jk(b) ,M, N, S, s, Le(a) , Le(b) , K, k. Kp(a) , Kp(b) , Fy(a) , Fy(b) , Lu(a) , Lu(b) , P1 and Di(a) using serological technology. Calculations of antigen and phenotype frequencies were expressed as percentages and for allele frequencies under the standard assumption of Hardy-Weinberg equilibrium. Amongst the Rh antigens, D was the most common (98.94%) followed by e (92.28%), C (88.81%), c (58.43%), E (50.78%) and C(w) (0.07%) with DCe/DCe (R1 R1 , 40.72%) being the most common phenotype. In the Kell blood group system, k was present in 100% of the donors and a rare phenotype, Kp (a+b+), was found in 0.28% of the donors. For the Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b-) were the most common phenotypes (44.05% and 84.35%, respectively). In the MNS blood group system, M+N+S-s+ (45.54%) was the most common, whereas M+N-S-s- and M-N+S-s- were not found. The rare Lu (a-b-) and Lu (a+b+) phenotypes were identified in 0.43% and 1.13% of the donors, respectively. Le(a) and Le(b) were seen in 17.92% and 63.03% of donors, respectively. The frequency of Di(a) was 4.75%, which was higher than in the Chinese population in Taiwan region or the Caucasian and Black populations (P < 0.0001). This study systematically describes the frequencies of 24 blood group antigens in the Chinese Han population from Mainland China. The data can be helpful in creating a donor database for preparation of indigenous cell panels and providing antigen-negative blood to patients with multiple alloantibodies.

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“…The LW b allele was found neither in 1,026 Somali Africans [15]nor in 500 Japanese samples, which may indicate its absence in African and Asiatic populations. Thus it would seem that the allele is confined to populations of north and northeastern Europe.…”

Section: Resultsmentioning

confidence: 99%

The LW<sup>b</sup> Blood Group as a Marker of Prehistoric Baltic Migrations and Admixture

et al. 1999

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Archaeological findings and historical records indicate frequent migrations and exchange of genetic material between populations in the Baltic Sea area. However, there have so far been very few attempts to trace migrations in this area using genetic markers. We have studied the Baltic populations with respect to exceptional variations in the frequencies of the Landsteiner-Wiener (LW) blood group. The frequency of the uncommon LW^b gene was high in the Balts, around 6% among Latvians and Lithuanians, very low among the other western Europeans (0–0.1%) and apparently absent in Asiatic and African populations. From the Baltic region of peak frequency there was a regular decline of LW^b incidence (a descending cline) in the neighboring populations: 4.0% in the Estonians, 2.9% in the Finns, 2.2% in the Vologda Russians, and 2.0% in the Poles. Thus the distribution of LW^b suggests considerable and extensive Baltic admixture, especially in the north and northeast direction. In Southern Sweden with an LW^b frequency of 0.3%, the Baltic influence appeared slight, while in the population of the Swedish island Gotland in the middle of the Baltic Sea there was a significantly incrased LW^b frequency of 1.0% compared with that of Western European countries. The distinction of codominantly inherited LW antigenic forms, LW^a and LW^b (previously Ne^a), is known to be due to a single base substitution. Based on our population data, it is plausible that the expansion of this point mutation occurred only once during human history. Furthermore, our data indicate that the expansion of the LW^b mutation occurred in Balts and that LW^b can be considered a ‘Baltic tribal marker’, its presence in other populations being an indicator of the degree of Baltic genetic influence.

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Distribution of Blood Groups in the East African Somali Population

Cited by 16 publications

References 14 publications

Evidence for Transmission of Plasmodium Vivax Among a Duffy Antigen Negative Population in Western Kenya

Evidence for Transmission of Plasmodium Vivax Among a Duffy Antigen Negative Population in Western Kenya

Frequencies of red blood cell major blood group antigens and phenotypes in the Chinese Han population from Mainland China

The LW<sup>b</sup> Blood Group as a Marker of Prehistoric Baltic Migrations and Admixture

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