Distribution of Catecholamines in the Ventral Mesencephalon of Human Brain, with Special Reference to Parkinson's Disease

Javoy‐Agid, F.; Taquet, H.; Ploska, Alain; Cherif‐Zahar, C.; Ruberg, Merle; Agid, Yves

doi:10.1111/j.1471-4159.1981.tb10843.x

Cited by 63 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, it is well known that in rat and human all regions with high receptor densities are richly innervated by dopamine containing fibers or contain dopamine cell bodies (Adolfsson et al, 1979;Bird and Iversen, 1982;Bj6rklund and Lindvall, 1984;Gaspar et al, 1983;Javoy-Agid et al, 1981;Pearson et al, 1983). Thus, in these two species, our results are in agreement with the known dopaminergic innervation and localization of dopamine cell bodies observed.…”

Section: Discussionsupporting

confidence: 95%

Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Camps¹,

Kelly²,

Palacios³

1990

J. Neural Transmission

198

View full text Add to dashboard Cite

Dopamine D 1 and D 2 receptor distributions were studied in the brain of the mouse, rat, guinea pig, cat and monkey by means of in vitro quantitative autoradiography using [3H]SCH 23390 and [3H]CV 205-502 to label D 1 and D 2 subtypes respectively. The distribution of both subtypes of receptors was similar within the basal ganglia of all species investigated. The highest densities for both subtypes were found in the nucleus caudatus, putamen, nucleus accumbens, olfactory tubercle and substantia nigra. Outside of the basal ganglia, differences in the distribution of both receptors were found among the species examined in regions such as cerebellum, cortex, hippocampus, superior colliculus and olfactory bulb. In all species D 1 receptor densities were higher than those of D 2. The absolute amount of both subtypes, however, varied among species. These results indicate that dopamine receptor distribution is well preserved in the basal ganglia during evolution, although differences among species exist in their distribution outside the basal ganglia and their absolute amount.

show abstract

Section: Discussionsupporting

confidence: 95%

Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Camps¹,

Kelly²,

Palacios³

1990

J. Neural Transmission

198

View full text Add to dashboard Cite

show abstract

“…The hypothesis that nigral dopamine receptors play an important role in the regulation of muscle tone is compatible with existing knowledge concerning the neurochemistry and treatment of Parkinson disease. For example, it is well known that there is a marked decrease in nigral, as well as striatal, dopamine concentration in Parkinson disease (27).…”

Section: Discussionmentioning

confidence: 99%

Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.

Double

Crocker

1995

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The aim of the present study was to localize the dopamine receptors involved in the regulation of muscle tone. A strategy was used whereby the effects on muscle tone of injecting the irreversible dopamine receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) in discrete brain regions were assessed. Increases in muscle tone were measured as changes in electromyographic activity of the gastrocnemius and tibialis muscles of conscious, unrestrained rats. No increases in muscle tone were found after injections of EEDQ into the anterior and posterior striatum, which produced marked reductions in dopamine receptor concentration. The effects on muscle tone of injecting EEDQ into the substantia nigra pars reticulata were also assessed. Large increases in muscle tone were observed associated with inactivation of either D1 or D2 dopamine receptors in the substantia nigra. The increased muscle tone was not reduced by subcutaneous administration of apomorphine, despite the presence of a normal population of striatal dopamine receptors. These findings provide evidence that dopamine receptors in the substantia nigra play an important role in the regulation of muscle tone. Further, they challenge the hypothesis that the muscle rigidity of Parkinson disease results primarily from loss of striatal dopamine receptor stimulation.The association of the characteristic symptoms of Parkinson disease-bradykinesia, tremor, and rigidity-with degeneration of nigrostriatal neurons (1) has led to the hypothesis that the neurochemical mechanism underlying these symptoms is a loss of dopamine release in the striatum. The success of L-dihydroxyphenylalanine (L-dopa) in alleviating the motor symptoms of Parkinson disease is attributed to augmentation of dopamine stores and the maintenance of striatal dopamine receptor stimulation (2). Experimental findings have also shown increased muscle tone (muscle rigidity) associated with reductions in striatal dopamine after lesioning of nigrostriatal neurons by the neurotoxin 6-hydroxydopamine (3) or after treatment with reserpine (3, 4).Although these findings have been interpreted as support for the striatal dopamine hypothesis, they have not taken into account that nigral dopaminergic neurons release dopamine from both their dendrites (5) and their terminals, so that dopamine concentration in the substantia nigra, as well as the striatum, will be reduced in Parkinson disease and after reserpine or 6-hydroxydopamine treatment. The aim of the present study was to investigate the role of striatal and nigral dopamine receptors in the regulation of muscle tone. The irreversible dopamine receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was injected into these regions, and the effects on muscle tone, measured as changes in the electromyographic (EMG) activity of the antagonistic muscles of the hind limb, were recorded. The area and extent of the resulting dopamine receptor inactivation were assessed using quantitative autoradiography so that the The publica...

show abstract

“…1,2 While denervation of dopaminergic nigrostriatal projections may explain the cardinal motor symptoms of PD, as evidenced by the dramatic motor improvement associated with dopamine therapy, 3 abnormalities beyond the SNc 4,5 may underlie the serious and potentially debilitating nonmotor features, including cognitive and memory impairments and progression to dementia. 6–10 Notably, the cholinergic basal forebrain (BF) also degenerates in PD 11,12 and could contribute to nonmotor deficits.…”

mentioning

confidence: 99%

Substantia Nigra Volume Loss Before Basal Forebrain Degeneration in Early Parkinson Disease

Ziegler

Wonderlick²,

Ashourian³

et al. 2013

JAMA Neurol

View full text Add to dashboard Cite

Distribution of Catecholamines in the Ventral Mesencephalon of Human Brain, with Special Reference to Parkinson's Disease

Cited by 63 publications

References 30 publications

Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.

Substantia Nigra Volume Loss Before Basal Forebrain Degeneration in Early Parkinson Disease

Contact Info

Product

Resources

About